World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
85
Citations
24776
World Ranking
2684
National Ranking
928

Biology and Biochemistry

D-Index
87
Citations
25777
World Ranking
2849
National Ranking
1462

Research.com Recognitions

  • 2020 - Fellow, National Academy of Inventors
  • 2003 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 1977 - Fellow of John Simon Guggenheim Memorial Foundation
  • 1975 - Fellow of Alfred P. Sloan Foundation

Overview

Sidney M. Hecht is affiliated with Arizona State University in the United States. Their research portfolio primarily spans the field of Biochemistry, Genetics, and Molecular Biology with a total of 37 publications. Within this main area, their work focuses on several subfields including Molecular Biology, Materials Chemistry, Oncology, Genetics, and Cancer Research.

The scientist's research topics include RNA and protein synthesis mechanisms, bacterial genetics and biotechnology, RNA modifications and cancer, DNA repair mechanisms, DNA and nucleic acid chemistry, glycosylation and glycoproteins research, and chemical synthesis and analysis.

Several recent papers authored or co-authored by Sidney M. Hecht demonstrate the breadth of their research. These include:

  • Interlocking activities of DNA polymerase β in the base excision repair pathway, 2022, Proceedings of the National Academy of Sciences
  • Antiferroptotic Activity of Phenothiazine Analogues: A Novel Therapeutic Strategy for Oxidative Stress Related Disease, 2020, ACS Medicinal Chemistry Letters
  • Expansion of the Genetic Code Through the Use of Modified Bacterial Ribosomes, 2021, Journal of Molecular Biology
  • Elongation Factor P Modulates the Incorporation of Structurally Diverse Noncanonical Amino Acids into Escherichia coli Dihydrofolate Reductase, 2023, Journal of the American Chemical Society
  • Protein synthesis with conformationally constrained cyclic dipeptides, 2020, Bioorganic & Medicinal Chemistry

Their collaboration network includes frequent co-authors such as Larisa M. Dedkova, Shengxi Chen, Sasha M. Daskalova, Omar M. Khdour, and Xiaoguang Bai. These partnerships underscore interdisciplinary approaches within their work.

Sidney M. Hecht has contributed to multiple publications in notable venues including Bioorganic & Medicinal Chemistry, ACS Chemical Biology, Biochemistry, The Cambridge Structural Database, and Proceedings of the National Academy of Sciences.

Recognition for this scientist's contributions has come in the form of prestigious fellowships. They have been named a Fellow of the National Academy of Inventors, a Fellow of the American Association for the Advancement of Science (AAAS), a Fellow of the John Simon Guggenheim Memorial Foundation, and a Fellow of the Alfred P. Sloan Foundation.

Best Publications

  • Oligonucleotide n-alkylphosphoramidates

    Sidney M. C O John W. Mallett Hecht

  • On the mechanism of topoisomerase I inhibition by camptothecin: evidence for binding to an enzyme-DNA complex

    Robert P. Hertzberg;Mary Jo Caranfa;Sidney M. Hecht

  • Synthesis of water-soluble (aminoalkyl)camptothecin analogues: inhibition of topoisomerase I and antitumor activity.

    William D. Kingsbury;Jeffrey C. Boehm;Dalia R. Jakas;Kenneth G. Holden

  • Bleomycin: new perspectives on the mechanism of action.

    Sidney M. Hecht

  • Camptothecin: current perspectives.

    Craig J. Thomas;Nicolas J. Rahier;Sidney M. Hecht

  • gamma Ray induced deoxyribonucleic acid strand breaks. 3' Glycolate termini.

    W D Henner;L O Rodriguez;S M Hecht;W A Haseltine

  • Eukaryotic mRNA cap binding protein: purification by affinity chromatography on sepharose-coupled m7GDP

    Nahum Sonenberg;Kathleen M. Rupprecht;Sidney M. Hecht;Aaron J. Shatkin

  • Identification of the First Specific Inhibitor of p90 Ribosomal S6 Kinase (RSK) Reveals an Unexpected Role for RSK in Cancer Cell Proliferation

    Jeffrey A. Smith;Celeste E. Poteet-Smith;Yaming Xu;Timothy M. Errington

  • Luotonin A. A Naturally Occurring Human DNA Topoisomerase I Poison

    Ali Cagir;Shannon H. Jones;Rong Gao;Brian M. Eisenhauer

  • The transcriptional complex between the BCL2 i-motif and hnRNP LL is a molecular switch for control of gene expression that can be modulated by small molecules.

    Hyun Jin Kang;Samantha Kendrick;Sidney M. Hecht;Laurence H. Hurley

  • Selective Tumor Cell Targeting by the Disaccharide Moiety of Bleomycin

    Zhiqiang Yu;Ryan M. Schmaltz;Trevor C. Bozeman;Rakesh Paul

  • T4 RNA ligase mediated preparation of novel "chemically misacylated" tRNAPheS.

    Thomas G. Heckler;Li Ho Chang;Yoshiyuki Zama;Takehiko Naka

  • The Dynamic Character of the BCL2 Promoter i-Motif Provides a Mechanism for Modulation of Gene Expression by Compounds That Bind Selectively to the Alternative DNA Hairpin Structure

    Samantha Kendrick;Hyun Jin Kang;Mohammad P. Alam;Manikandadas M. Madathil

  • Sequence Selective Cleavage of a DNA Octanucleotide by Chlorinated Bithiazoles and Bleomycins

    Guy Zuber;James C. Quada;Sidney M. Hecht

  • Enhanced D-amino acid incorporation into protein by modified ribosomes.

    Larisa M. Dedkova;Nour Eddine Fahmi;Serguei Y. Golovine;Sidney M. Hecht

  • Mitochondrial Nitroreductase Activity Enables Selective Imaging and Therapeutic Targeting

    Arnaud Chevalier;Yanmin Zhang;Omar M. Khdour;Justin B. Kaye

  • Oligonucleotide N-alkylphosphoramidates: synthesis and binding to polynucleotides

    Alfred Jager;Mark J. Levy;Sidney M. Hecht

  • Copper-dependent cleavage of DNA by bleomycin

    Ehrenfeld Gm;Shipley Jb;Heimbrook Dc;Sugiyama H

  • Javaniside, a novel DNA cleavage agent from Alangium javanicum having an unusual oxindole skeleton

    Ji Ma;Sidney M. Hecht

  • RNA Degradation by Bleomycin, a Naturally Occurring Bioconjugate

    Sidney M. Hecht

Frequent Co-Authors

Nelson J. Leonard
Nelson J. Leonard University of Illinois at Urbana-Champaign
Folke Skoog
Folke Skoog University of Wisconsin–Madison
Hiroshi Sugiyama
Hiroshi Sugiyama Kyoto University
Craig J. Thomas
Craig J. Thomas National Institutes of Health
G. A. Van Der Marel
G. A. Van Der Marel Leiden University
Xiang Zhou
Xiang Zhou Wuhan University
Stewart Shuman
Stewart Shuman Memorial Sloan Kettering Cancer Center
Stephen J. Benkovic
Stephen J. Benkovic Pennsylvania State University
Jia Zhou
Jia Zhou The University of Texas Medical Branch at Galveston

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