What is he best known for?
The fields of study he is best known for:
His scientific interests lie mostly in RNA, Oligonucleotide, Biochemistry, RNase P and RNase H.
His study looks at the intersection of RNA and topics like Cell biology with Gene expression and Messenger RNA.
His work on Antisense oligonucleotides as part of general Oligonucleotide study is frequently connected to Mechanism, therefore bridging the gap between diverse disciplines of science and establishing a new relationship between them.
His work on Nuclease, Enzyme, Binding site and Binding selectivity as part of general Biochemistry study is frequently linked to Ribostamycin, therefore connecting diverse disciplines of science.
His research on RNase P frequently links to adjacent areas such as Molecular biology.
His RNase H study integrates concerns from other disciplines, such as Cleavage and RNase MRP.
His most cited work include:
- Efficient Reduction of Target RNAs by Small Interfering RNA and RNase H-dependent Antisense Agents: A COMPARATIVE ANALYSIS * (705 citations)
- Mipomersen, an apolipoprotein B synthesis inhibitor, for lowering of LDL cholesterol concentrations in patients with homozygous familial hypercholesterolaemia: a randomised, double-blind, placebo-controlled trial. (674 citations)
- Progress in Antisense Technology (425 citations)
What are the main themes of his work throughout his whole career to date?
His primary areas of investigation include Oligonucleotide, RNA, Molecular biology, Biochemistry and RNase P.
His research investigates the connection with Oligonucleotide and areas like Computational biology which intersect with concerns in Drug discovery.
His studies in RNA integrate themes in fields like Gene silencing and Function, Cell biology.
The Molecular biology study combines topics in areas such as RNA-induced silencing complex, Small interfering RNA, Messenger RNA, Gene and Nuclease protection assay.
His RNase P study combines topics in areas such as Cleavage and DNA.
As a part of the same scientific study, Stanley T. Crooke usually deals with the Antisense oligonucleotides, concentrating on Pharmacology and frequently concerns with Apolipoprotein B.
He most often published in these fields:
- Oligonucleotide (35.96%)
- RNA (30.34%)
- Molecular biology (28.09%)
What were the highlights of his more recent work (between 2011-2021)?
- Oligonucleotide (35.96%)
- Cell biology (19.66%)
- RNA (30.34%)
In recent papers he was focusing on the following fields of study:
Stanley T. Crooke mostly deals with Oligonucleotide, Cell biology, RNA, RNase P and Molecular biology.
His Oligonucleotide study is related to the wider topic of Biochemistry.
His Cell biology study incorporates themes from Cell and RNA splicing.
His biological study spans a wide range of topics, including Regulation of gene expression, Computational biology, Gene expression and Recombinant DNA.
His work deals with themes such as Locked nucleic acid, Messenger RNA, Transcription and Antisense Technology, which intersect with RNase P.
Stanley T. Crooke combines subjects such as Cytoplasm, Exosome complex, Small interfering RNA, RNA silencing and RNase MRP with his study of Molecular biology.
Between 2011 and 2021, his most popular works were:
- Antisense oligonucleotides targeting apolipoprotein(a) in people with raised lipoprotein(a): two randomised, double-blind, placebo-controlled, dose-ranging trials (361 citations)
- Antisense Oligonucleotide Inhibition of Apolipoprotein C-III Reduces Plasma Triglycerides in Rodents, Nonhuman Primates, and Humans (258 citations)
- Single-Stranded RNAs Use RNAi to Potently and Allele-Selectively Inhibit Mutant Huntingtin Expression (233 citations)
In his most recent research, the most cited papers focused on:
Stanley T. Crooke mainly focuses on RNA, Oligonucleotide, RNase P, Molecular biology and Cell biology.
His research in RNA intersects with topics in Gene silencing and Gene expression.
Oligonucleotide is a primary field of his research addressed under Biochemistry.
His work in the fields of Biochemistry, such as Phosphorothioate Oligonucleotides and Nuclease, intersects with other areas such as Endocytosis Pathway.
His RNase P research includes themes of Locked nucleic acid, Cytoplasm and Messenger RNA.
His work in Cell biology covers topics such as Paraspeckle which are related to areas like Small nuclear RNA, RNA silencing and Non-coding RNA.
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