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Molecular Biology

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102
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Overview

Stanley T. Crooke is affiliated with Ionis Pharmaceuticals in the United States, where their research focuses primarily on biochemistry, genetics, and molecular biology. Their work encompasses various subfields including molecular biology, genetics, immunology, cell biology, and cancer research.

The research topics covered by Stanley T. Crooke include:

  • DNA and Nucleic Acid Chemistry
  • Advanced biosensing and bioanalysis techniques
  • RNA Interference and Gene Delivery
  • RNA Research and Splicing
  • CRISPR and Genetic Engineering
  • Genomics and Rare Diseases
  • Neurogenetic and Muscular Disorders Research

Stanley T. Crooke has contributed to multiple scientific publications, with several recent papers including the following:

  • Antisense technology: an overview and prospectus, 2021, Nature Reviews Drug Discovery
  • Phosphorothioate modified oligonucleotide-protein interactions, 2020, Nucleic Acids Research
  • Antisense technology: A review, 2021, Journal of Biological Chemistry
  • The Interaction of Phosphorothioate-Containing RNA Targeted Drugs with Proteins Is a Critical Determinant of the Therapeutic Effects of These Agents, 2020, Journal of the American Chemical Society
  • Towards next generation antisense oligonucleotides: mesylphosphoramidate modification improves therapeutic index and duration of effect of gapmer antisense oligonucleotides, 2021, Nucleic Acids Research

The venues where Stanley T. Crooke has frequently published research include:

  • Nucleic Acid Therapeutics
  • Nucleic Acids Research
  • Journal of the American Chemical Society
  • Nature Biotechnology
  • Nature Medicine

Stanley T. Crooke regularly collaborates with coauthors such as:

  • Xue-hai Liang
  • Timothy A. Vickers
  • Punit P. Seth
  • Cheryl Li De Hoyos
  • Lingdi Zhang

Best Publications

  • Antisense Research and Applications

    Sudhir Agrawal;Stanley T. Crooke

  • Mipomersen, an apolipoprotein B synthesis inhibitor, for lowering of LDL cholesterol concentrations in patients with homozygous familial hypercholesterolaemia: a randomised, double-blind, placebo-controlled trial.

    Frederick J Raal;Raul D Santos;Dirk J Blom;A David Marais

  • Therapeutic Applications of Oligonucleotides

    Stanley T. Crooke

  • Efficient Reduction of Target RNAs by Small Interfering RNA and RNase H-dependent Antisense Agents: A COMPARATIVE ANALYSIS *

    Timothy A. Vickers;Seongjoon Koo;C. Frank Bennett;Stanley T. Crooke

  • RNA-Targeted Therapeutics.

    Stanley T. Crooke;Joseph L. Witztum;C. Frank Bennett;Brenda F. Baker

  • Cisplatin : current status and new developments

    Archie W. Prestayko;Stanley T. Crooke;Stephen K. Carter

  • Antisense drug technology : principles, strategies, and applications

    Stanley T. Crooke

  • Progress in Antisense Technology

    Stanley T. Crooke

  • Antisense oligonucleotides targeting apolipoprotein(a) in people with raised lipoprotein(a): two randomised, double-blind, placebo-controlled, dose-ranging trials

    Nicholas J Viney;Julian C van Capelleveen;Richard S Geary;Shuting Xia

  • Oligoribonucleotides and ribonucleases for cleaving RNA

    Stanley T. Crooke

  • Mitomycin C: a review

    Stanley T. Crooke;William T. Bradner

  • Biochemical and pharmacological properties of p170 and p180 forms of topoisomerase II

    Fred H. Drake;Glenn A. Hofmann;Henry F. Bartus;Michael R. Mattern

  • Molecular mechanisms of action of antisense drugs.

    Stanley T Crooke

  • Oligoribonucleotides for cleaving RNA

    Stanley T. Crooke

  • Cisplatin (cis-diamminedichloroplatinum II).

    A.W. Prestayko;J.C. D'Aoust;B.F. Issell;S.T. Crooke

  • Cellular uptake and trafficking of antisense oligonucleotides

    Stanley T Crooke;Shiyu Wang;Timothy A Vickers;Wen Shen

  • Inhibition of proteolysis and cell cycle progression in a multiubiquitination-deficient yeast mutant.

    Daniel Finley;Seth Sadis;Brett P. Monia;Paul Boucher

  • Progress in antisense oligonucleotide therapeutics.

    S T Crooke;C F Bennett

  • Antisense technology: an overview and prospectus

    Stanley T Crooke;Brenda F Baker;Rosanne M Crooke;Xue-Hai Liang

  • Basic Principles of Antisense Therapeutics

    S. T. Crooke

Frequent Co-Authors

David J. Ecker
David J. Ecker Ionis Pharmaceuticals (United States)
Eric E. Swayze
Eric E. Swayze Ionis Pharmaceuticals (United States)
Rosanne M. Crooke
Rosanne M. Crooke Ionis Pharmaceuticals (United States)
Richard S. Geary
Richard S. Geary Ionis Pharmaceuticals (United States)
Punit P. Seth
Punit P. Seth Ionis Pharmaceuticals (United States)
C. Frank Bennett
C. Frank Bennett Ionis Pharmaceuticals (United States)
Brett P. Monia
Brett P. Monia Ionis Pharmaceuticals (United States)
Lawrence B. Blyn
Lawrence B. Blyn Ionis Pharmaceuticals (United States)
Sotirios Tsimikas
Sotirios Tsimikas University of California, San Diego
Muthiah Manoharan
Muthiah Manoharan Alnylam Pharmaceuticals (United States)

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