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D-Index & Metrics

Molecular Biology

D-Index
90
Citations
29615
World Ranking
737
National Ranking
398

Research.com Recognitions

  • 2013 - Member of the National Academy of Sciences
  • 2012 - Fellow of the American Academy of Arts and Sciences

Overview

James M. Berger is affiliated with Johns Hopkins University in the United States. Their research primarily focuses on biochemistry, genetics, and molecular biology, with a substantial body of work totaling 113 publications in this field. Within this broad area, they have contributed extensively to molecular biology, oncology, genetics, molecular medicine, and ecology.

The scientist has explored several specific research topics, including:

  • Cancer therapeutics and mechanisms
  • DNA repair mechanisms
  • DNA and nucleic acid chemistry
  • Bacterial genetics and biotechnology
  • Lung cancer research studies
  • Genomics and chromatin dynamics
  • Antibiotic resistance in bacteria

Notable publication venues where this researcher frequently publishes include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nucleic Acids Research
  • Biophysical Journal
  • Nature Chemical Biology
  • Nature Communications

Frequent coauthors of James M. Berger are:

  • Joyce H. Lee
  • James T. Inman
  • Michelle D. Wang
  • Joshua Jeong
  • Taekjip Ha

Selected recent papers include:

  • "Mechanisms of hexameric helicases," 2021, Critical Reviews in Biochemistry and Molecular Biology
  • "Structural and functional characterization of the Spo11 core complex," 2021, Nature Structural & Molecular Biology
  • "Structural Mechanisms for Replicating DNA in Eukaryotes," 2021, Annual Review of Biochemistry
  • "Etoposide promotes DNA loop trapping and barrier formation by topoisomerase II," 2023, Nature Chemical Biology
  • "Evybactin is a DNA gyrase inhibitor that selectively kills Mycobacterium tuberculosis," 2022, Nature Chemical Biology

James M. Berger has been recognized with the following awards:

  • Member of the National Academy of Sciences, 2013
  • Fellow of the American Academy of Arts and Sciences, 2012

Best Publications

  • Core structure of GP41 from the HIV envelope glycoprotein

    David C. Chan;Deborah Fass;Min Lu;James M. Berger

  • Structure and mechanism of DNA topoisomerase II

    James M. Berger;Steven J. Gamblin;Steven J. Gamblin;Stephen C. Harrison;James C. Wang

  • Evolutionary relationships and structural mechanisms of AAA+ proteins.

    Jan P. Erzberger;James M. Berger

  • A robust and scalable microfluidic metering method that allows protein crystal growth by free interface diffusion.

    Carl L. Hansen;Emmanuel Skordalakes;James M. Berger;Stephen R. Quake

  • Formation of MacroH2A-Containing Senescence-Associated Heterochromatin Foci and Senescence Driven by ASF1a and HIRA

    Rugang Zhang;Maxim V. Poustovoitov;Maxim V. Poustovoitov;Xiaofen Ye;Hidelita A. Santos

  • Neurexin mediates the assembly of presynaptic terminals.

    Camin Dean;Francisco G Scholl;Jenny Choih;Shannon DeMaria

  • All tangled up: how cells direct, manage and exploit topoisomerase function

    Seychelle M. Vos;Elsa M. Tretter;Bryan H. Schmidt;James M. Berger

  • DNA topoisomerases: harnessing and constraining energy to govern chromosome topology.

    Allyn J. Schoeffler;James M. Berger

  • DNA replication initiation: mechanisms and regulation in bacteria.

    Melissa L. Mott;James M. Berger

  • Structure, Molecular Mechanisms, and Evolutionary Relationships in DNA Topoisomerases

    Kevin D. Corbett;James M. Berger

  • Molecular basis of familial hypercholesterolaemia from structure of LDL receptor module.

    Deborah Fass;Stephen Blacklow;Stephen Blacklow;Peter S. Kim;James M. Berger

  • Antitumor bisdioxopiperazines inhibit yeast DNA topoisomerase II by trapping the enzyme in the form of a closed protein clamp.

    Joaquim Roca;Ryoji Ishida;James M. Berger;Toshiwo Andoh

  • Structure of Human cGAS Reveals a Conserved Family of Second-Messenger Enzymes in Innate Immunity

    Philip J. Kranzusch;Amy Si Ying Lee;James M. Berger;James M. Berger;Jennifer A. Doudna

  • Structural basis for ATP-dependent DnaA assembly and replication-origin remodeling

    Jan P Erzberger;Melissa L Mott;James M Berger

  • The structural basis for MCM2-7 helicase activation by GINS and Cdc45.

    Alessandro Costa;Ivar Ilves;Nele Tamberg;Tatjana Petojevic;Tatjana Petojevic

  • Structural basis for gate-DNA recognition and bending by type IIA topoisomerases

    Ken C. Dong;James M. Berger

  • Activation of the DExD/H-box protein Dbp5 by the nuclear-pore protein Gle1 and its coactivator InsP6 is required for mRNA export.

    Christine S. Weirich;Jan P. Erzberger;Jeffrey S. Flick;Jeffrey S. Flick;James M. Berger

  • Structure of the topoisomerase II ATPase region and its mechanism of inhibition by the chemotherapeutic agent ICRF-187

    Scott Classen;Stephane Olland;James M. Berger

  • Running in reverse: the structural basis for translocation polarity in hexameric helicases

    Nathan D. Thomsen;James M. Berger

  • Histone chaperone Asf1 is required for histone H3 lysine 56 acetylation, a modification associated with S phase in mitosis and meiosis

    J. Recht;T. Tsubota;J. C. Tanny;R. L. Diaz

Frequent Co-Authors

Michael R. Botchan
Michael R. Botchan University of California, Berkeley
Kevin D. Corbett
Kevin D. Corbett University of California, San Diego
Jennifer A. Doudna
Jennifer A. Doudna University of California, Berkeley
Jacob E. Corn
Jacob E. Corn ETH Zurich
Eva Nogales
Eva Nogales University of California, Berkeley
Neil Osheroff
Neil Osheroff Vanderbilt University
James C. Wang
James C. Wang Harvard University
Stephen R. Quake
Stephen R. Quake Stanford University
Scott Keeney
Scott Keeney Memorial Sloan Kettering Cancer Center
Paul D. Kaufman
Paul D. Kaufman University of Massachusetts Chan Medical School

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