Yuxian He spends much of his time researching Virology, Antibody, Coronavirus, Virus and Epitope. His Virology research includes themes of Molecular biology, Microbiology and BALB/c. His research in the fields of Antiserum overlaps with other disciplines such as Protein subunit.
His Virus research includes elements of Multiple drug resistance and In vivo. His work focuses on many connections between Epitope and other disciplines, such as Neutralization, that overlap with his field of interest in Monoclonal antibody, Binding site and Antigen. His work in Transmembrane protein addresses issues such as Glycoprotein, which are connected to fields such as Biophysics, Heptad repeat, Circular dichroism and Peptide.
The scientist’s investigation covers issues in Virology, Antibody, Gp41, Coronavirus and Peptide. His study in Virology focuses on Virus in particular. The study incorporates disciplines such as Receptor, Microbiology and Lentivirus in addition to Virus.
His work deals with themes such as Molecular biology and Antigen, which intersect with Antibody. His Gp41 research is multidisciplinary, relying on both Biochemistry, Lipid bilayer fusion, Cell fusion and Heptad repeat. His Peptide research incorporates themes from Mechanism of action, Leucine, Structure–activity relationship, Computational biology and In vivo.
Yuxian He mainly focuses on Virology, Gp41, Lipid bilayer fusion, Enfuvirtide and Lipopeptide. His biological study spans a wide range of topics, including Epitope, Antibody and Lipid raft. His Epitope study integrates concerns from other disciplines, such as Cytotoxic T cell, MHC class I and Monoclonal antibody.
His specific area of interest is Antibody, where Yuxian He studies Neutralizing antibody. His research in Gp41 tackles topics such as Peptide which are related to areas like Heptad repeat, Amino acid, Mechanism of action and Residue. His study in Enfuvirtide is interdisciplinary in nature, drawing from both Viral entry and Cell fusion.
Yuxian He focuses on Virology, Severe acute respiratory syndrome coronavirus 2, Infectivity, Vaccine efficacy and BALB/c. Yuxian He has included themes like Heptad repeat, Cell fusion and In vivo in his Virology study. His Heptad repeat study incorporates themes from Lipid bilayer fusion and Peptide.
The various areas that he examines in his Cell fusion study include Gp41, Enfuvirtide, Viral load, Viral entry and Simian immunodeficiency virus. There are a combination of areas like Animal model, Protein subunit and Antibody integrated together with his Severe acute respiratory syndrome coronavirus 2 study. His 2019-20 coronavirus outbreak research is multidisciplinary, incorporating elements of Epitope, Monoclonal antibody and Cross neutralization.
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The spike protein of SARS-CoV — a target for vaccine and therapeutic development
Lanying Du;Yuxian He;Yusen Zhou;Shuwen Liu.
Nature Reviews Microbiology (2009)
Evidence that TMPRSS2 Activates the Severe Acute Respiratory Syndrome Coronavirus Spike Protein for Membrane Fusion and Reduces Viral Control by the Humoral Immune Response
Ilona Glowacka;Stephanie Bertram;Marcel A. Müller;Paul Allen.
Journal of Virology (2011)
Interaction between heptad repeat 1 and 2 regions in spike protein of SARS-associated coronavirus: implications for virus fusogenic mechanism and identification of fusion inhibitors.
Shuwen Liu;Gengfu Xiao;Yibang Chen;Yuxian He.
The Lancet (2004)
Adaptation of SARS-CoV-2 in BALB/c mice for testing vaccine efficacy.
Hongjing Gu;Qi Chen;Guan Yang;Lei He.
Receptor-binding domain of SARS-CoV spike protein induces highly potent neutralizing antibodies: implication for developing subunit vaccine.
Yuxian He;Yusen Zhou;Shuwen Liu;Zhihua Kou.
Biochemical and Biophysical Research Communications (2004)
The V1/V2 domain of gp120 is a global regulator of the sensitivity of primary human immunodeficiency virus type 1 isolates to neutralization by antibodies commonly induced upon infection.
Abraham Pinter;William J. Honnen;Yuxian He;Miroslaw K. Gorny.
Journal of Virology (2004)
IFITM proteins restrict viral membrane hemifusion
Kun Li;Ruben M. Markosyan;Yi-Min Zheng;Ottavia Golfetto.
PLOS Pathogens (2013)
Receptor-binding domain of severe acute respiratory syndrome coronavirus spike protein contains multiple conformation-dependent epitopes that induce highly potent neutralizing antibodies.
Yuxian He;Hong Lu;Pamela Siddiqui;Yusen Zhou.
Journal of Immunology (2005)
N-Substituted Pyrrole Derivatives as Novel Human Immunodeficiency Virus Type 1 Entry Inhibitors That Interfere with the gp41 Six-Helix Bundle Formation and Block Virus Fusion
Shibo Jiang;Hong Lu;Shuwen Liu;Qian Zhao.
Antimicrobial Agents and Chemotherapy (2004)
Potent cross-reactive neutralization of SARS coronavirus isolates by human monoclonal antibodies
Zhongyu Zhu;Samitabh Chakraborti;Yuxian He;Anjeanette Roberts.
Proceedings of the National Academy of Sciences of the United States of America (2007)
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