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Overview

Sergio A. Jimenez is affiliated with Thomas Jefferson University in the United States. Their research primarily focuses on systemic sclerosis and related diseases, contributing a significant number of publications across various fields of medicine and molecular biology.

The scientist's work covers interdisciplinary fields including:

  • Medicine
  • Biochemistry, Genetics and Molecular Biology

Key subfields of their research involve:

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Pulmonary and Respiratory Medicine
  • Dermatology
  • Artificial Intelligence

The main topics explored in their publications include:

  • Systemic Sclerosis and Related Diseases
  • Dermatologic Treatments and Research
  • Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
  • Inflammatory Myopathies and Dermatomyositis
  • Extracellular vesicles in disease
  • Eosinophilic Disorders and Syndromes
  • TGF-β signaling in diseases

Among the frequently published venues for their research are:

  • Clinical and Experimental Rheumatology
  • Lara D. Veeken
  • Journal of Clinical Medicine
  • Annals of the Rheumatic Diseases
  • Translational research

Notable recent papers authored or co-authored by Sergio A. Jimenez include:

  • Long non-coding RNA HOTAIR drives EZH2-dependent myofibroblast activation in systemic sclerosis through miRNA 34a-dependent activation of NOTCH (2020, Annals of the Rheumatic Diseases)
  • Oxidative Stress Induced by Reactive Oxygen Species (ROS) and NADPH Oxidase 4 (NOX4) in the Pathogenesis of the Fibrotic Process in Systemic Sclerosis: A Promising Therapeutic Target (2021, Journal of Clinical Medicine)
  • Tyrosine kinases in the pathogenesis of tissue fibrosis in systemic sclerosis and potential therapeutic role of their inhibition (2021, Translational research)
  • Increased expression of interferon regulated and antiviral response genes in CD31+/CD102+ lung microvascular endothelial cells from systemic sclerosis patients with end-stage interstitial lung disease (2021, Clinical and Experimental Rheumatology)
  • Serine/threonine kinase inhibition as antifibrotic therapy: transforming growth factor-β and Rho kinase inhibitors (2021, Lara D. Veeken)

Sergio A. Jimenez collaborates frequently with several co-authors including:

  • Sonsoles Piera-Velázquez
  • Fabian A. Mendoza
  • Giuseppina Abignano
  • Heidi M. Hermes
  • Francesco Del Galdo

Best Publications

  • 2013 classification criteria for systemic sclerosis: An american college of rheumatology/European league against rheumatism collaborative initiative

    Frank Van Den Hoogen;Dinesh Khanna;Jaap Fransen;Sindhu R. Johnson

  • Osteoarthritis cartilage histopathology: grading and staging

    K P H Pritzker;K P H Pritzker;S A Jimenez;K Ostergaard

  • NF-κB as a potential therapeutic target in osteoarthritis and rheumatoid arthritis

    J.A. Roman-Blas;S.A. Jimenez

  • Transforming growth factor beta (TGF beta) causes a persistent increase in steady-state amounts of type I and type III collagen and fibronectin mRNAs in normal human dermal fibroblasts.

    J Varga;J Rosenbloom;S A Jimenez

  • Role of Endothelial-Mesenchymal Transition (EndoMT) in the Pathogenesis of Fibrotic Disorders

    Sonsoles Piera-Velazquez;Zhaodong Li;Sergio A. Jimenez

  • Identification of fetal DNA and cells in skin lesions from women with systemic sclerosis.

    Artlett Cm;Smith Jb;Jimenez Sa

  • Analysis of 13 cell types reveals evidence for the expression of numerous novel primate- And tissue-specific microRNAs

    Eric Londina;Phillipe Lohera;Aristeidis G. Telonis;Kevin Quann

  • A disease severity scale for systemic sclerosis: development and testing.

    T A Medsger;A J Silman;V D Steen;C M Black

  • Intravenous Iloprost Infusion in Patients with Raynaud Phenomenon Secondary to Systemic Sclerosis: A Multicenter, Placebo-controlled, Double-Blind Study

    Fredrick M. Wigley;Robert A. Wise;James R. Seibold;Deborah A. McCloskey

  • Endothelial to Mesenchymal Transition: Role in Physiology and in the Pathogenesis of Human Diseases.

    Sonsoles Piera-Velazquez;Sergio A. Jimenez

  • Selective inhibition of human diploid fibroblast collagen synthesis by interferons.

    S A Jimenez;B Freundlich;J Rosenbloom

  • Following the Molecular Pathways toward an Understanding of the Pathogenesis of Systemic Sclerosis

    Sergio A. Jimenez;Chris T. Derk

  • Measuring disease activity and functional status in patients with scleroderma and Raynaud's phenomenon

    Peter A. Merkel;Peter A. Merkel;Karen Herlyn;Richard W. Martin;Jennifer J. Anderson

  • A tandem duplication within the fibrillin 1 gene is associated with the mouse tight skin mutation.

    Linda D. Siracusa;Rodney McGrath;Qing Ma;John J. Moskow

  • Stop codon in the procollagen II gene (COL2A1) in a family with the Stickler syndrome (arthro-ophthalmopathy).

    Nilofer Nina Ahmad;Leena Ala-Kokko;Robert G. Knowlton;Sergio A. Jimenez

  • Treatment of systemic sclerosis with extracorporeal photochemotherapy. Results of a multicenter trial.

    Alain H. Rook;Bruce Freundlich;Brian V. Jegasothy;Maritza I. Perez

  • Description of 12 Cases of Nephrogenic Fibrosing Dermopathy and Review of the Literature

    Fabian A. Mendoza;Carol M. Artlett;Nora Sandorfi;Kevin Latinis

  • Hydroxyproline content determines the denaturation temperature of chick tendon collagen.

    Joel Rosenbloom;Margaret Harsch;Sergio Jimenez

  • The gastrointestinal manifestations of scleroderma: pathogenesis and management

    Sidney Cohen;Igor Laufer;William J. Snape;Yih-Fu Shiau

  • Narrative Review: Fibrotic Diseases: Cellular and Molecular Mechanisms and Novel Therapies

    Joel Rosenbloom;Susan V. Castro;Sergio A. Jimenez

Frequent Co-Authors

John Varga
John Varga University of Michigan–Ann Arbor
Joel Rosenbloom
Joel Rosenbloom Thomas Jefferson University
Jouni Uitto
Jouni Uitto Thomas Jefferson University
Linda D. Siracusa
Linda D. Siracusa Thomas Jefferson University
Darwin J. Prockop
Darwin J. Prockop Texas A&M University
Alisa E. Koch
Alisa E. Koch University of Michigan–Ann Arbor
Gerd G. Maul
Gerd G. Maul The Wistar Institute
Yannick Allanore
Yannick Allanore Université Paris Cité
Oliver Distler
Oliver Distler University of Zurich
Christopher P. Denton
Christopher P. Denton University College London

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