World's Best Scientists 2026 revealed!
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Best Scientists
2025
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Biology and Biochemistry
USA
2026

D-Index & Metrics

Best Scientists

D-Index
167
Citations
121526
World Ranking
968
National Ranking
574

Biology and Biochemistry

D-Index
171
Citations
127326
World Ranking
84
National Ranking
65

Research.com Recognitions

  • 2026 - Research.com Biology and Biochemistry in United States Leader Award
  • 2025 - Research.com Best Scientists Award
  • 2025 - Research.com Biology and Biochemistry in United States Leader Award
  • 2016 - Max Delbruck Prize, Division of Biological Physics of the American Physical Society For invention of large-scale microfluidic integration and its use to gain new insights into protein crystallography, transcription factor binding, and microbial ecology, and for seminal discoveries in single cell and single molecule genome analysis.
  • 2014 - Fellow of the American Academy of Arts and Sciences
  • 2013 - Fellow, National Academy of Inventors
  • 2013 - Member of the National Academy of Engineering For achievements in single-cell analysis and large-scale integration of microfluidic devices.
  • 2013 - Member of the National Academy of Sciences
  • 2012 - Member of the National Academy of Medicine (NAM)
  • 2011 - Promega Biotechnology Research Award, American Society for Microbiology
  • 2010 - Fellow of the Indian National Academy of Engineering (INAE)
  • 2009 - Fellow of American Physical Society (APS) Citation For his pioneering contributions to biophysics, in the study of both single molecule and microfluid physics, including the development of integrated microfluidics, leading to novel platforms for modifying, detecting, and characterizing biomolecules
  • 2004 - National Institutes of Health Director's Pioneer Award

Overview

Stephen R. Quake is affiliated with Stanford University in the United States. Their research primarily spans the fields of Biochemistry, Genetics and Molecular Biology, with a significant focus also on Medicine. Within these broad areas, their work includes Molecular Biology, Immunology, Cancer Research, Obstetrics and Gynecology, and Pediatrics, Perinatology and Child Health.

The scientist's research topics cover several key areas including Single-cell and spatial transcriptomics, RNA Research and Splicing, Cell Image Analysis Techniques, Cancer-related molecular mechanisms research, RNA modifications and cancer, Neonatal Respiratory Health Research, and Neuroinflammation and Neurodegeneration Mechanisms.

Quake has contributed frequently to a number of publication venues, most notably:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature
  • eLife
  • Proceedings of the National Academy of Sciences
  • Cell

Recent papers authored or co-authored by Stephen R. Quake include:

  • "SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues" (2020), published in Cell
  • "A molecular cell atlas of the human lung from single-cell RNA sequencing" (2020), published in Nature
  • "A single-cell transcriptomic atlas characterizes ageing tissues in the mouse" (2020), published in Nature
  • "The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans" (2022), published in Science
  • "Fly Cell Atlas: A single-nucleus transcriptomic atlas of the adult fruit fly" (2022), published in Science

Frequent co-authors collaborating with Quake include Robert C. Jones, Liqun Luo, Norma Neff, Mira N. Moufarrej, and Sai Saroja Kolluru.

Among the awards received by Quake are the Max Delbruck Prize, awarded in 2016 by the Division of Biological Physics of the American Physical Society for contributions to microfluidic integration and single cell genome analysis, and election as a Fellow of the American Academy of Arts and Sciences in 2014. Other distinctions include membership in the National Academy of Engineering and the National Academy of Sciences, fellowship in the National Academy of Inventors, and recognition by the National Academy of Medicine.

Additional honors include the Promega Biotechnology Research Award by the American Society for Microbiology in 2011, fellowship in the Indian National Academy of Engineering in 2010, and fellowship in the American Physical Society in 2009 for pioneering contributions to biophysics and integrated microfluidics. Quake also received the National Institutes of Health Director's Pioneer Award in 2004.

Best Publications

  • Microfluidics: Fluid physics at the nanoliter scale

    Todd M. Squires;Stephen R. Quake

  • Monolithic microfabricated valves and pumps by multilayer soft lithography

    Marc A. Unger;Hou-Pu Chou;Todd Thorsen;Axel Scherer

  • Microfluidic large scale integration

    Sebastian J. Maerkl;Todd A. Thorsen;Xiaoyan Bao;Stephen R. Quake

  • Association of reactive oxygen species levels and radioresistance in cancer stem cells

    Maximilian Diehn;Robert W. Cho;Neethan A. Lobo;Tomer Kalisky

  • Dynamic pattern formation in a vesicle-generating microfluidic device.

    Todd Thorsen;Richard W. Roberts;Frances H. Arnold;Stephen R. Quake

  • SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues.

    Carly G.K. Ziegler;Samuel J. Allon;Sarah K. Nyquist;Ian M. Mbano

  • Developing optofluidic technology through the fusion of microfluidics and optics

    Demetri Psaltis;Stephen R. Quake;Changhuei Yang

  • From Micro- to Nanofabrication with Soft Materials

    Stephen R. Quake;Axel Scherer

  • The Human Cell Atlas

    Aviv Regev;Aviv Regev;Aviv Regev;Sarah A Teichmann;Sarah A Teichmann;Sarah A Teichmann;Eric S Lander;Eric S Lander;Eric S Lander;Ido Amit

  • A survey of human brain transcriptome diversity at the single cell level

    Spyros Darmanis;Steven A. Sloan;Ye Zhang;Martin Enge

  • Noninvasive diagnosis of fetal aneuploidy by shotgun sequencing DNA from maternal blood

    H. Christina Fan;Yair J. Blumenfeld;Usha Chitkara;Louanne Hudgins

  • A microfabricated fluorescence-activated cell sorter

    Anne Y. Fu;Charles Spence;Axel Scherer;Frances H. Arnold

  • Reconstructing lineage hierarchies of the distal lung epithelium using single cell RNA-seq

    Barbara Treutlein;Doug G. Brownfield;Angela Ruohao Wu;Norma F. Neff

  • Single-cell genome sequencing: current state of the science

    Charles Gawad;Winston Koh;Winston Koh;Stephen R. Quake;Stephen R. Quake

  • A molecular cell atlas of the human lung from single-cell RNA sequencing.

    Kyle J. Travaglini;Ahmad N. Nabhan;Ahmad N. Nabhan;Lolita Penland;Rahul Sinha

  • Single-Molecule DNA Sequencing of a Viral Genome

    Timothy D. Harris;Phillip R. Buzby;Hazen Babcock;Eric Beer

  • Microfluidic Large-Scale Integration: The Evolution of Design Rules for Biological Automation

    Jessica Melin;Stephen R. Quake

  • Nucleic acid amplification using microfluidic devices

    Markus M. Enzelberger;Carl L. Hansen;Jian Liu;Stephen R. Quake

  • Microfluidic Large Scale Integration

    Stephen Quake

  • Noninvasive diagnosis of fetal aneuploidy by shotgun sequencing DNA from maternal blood. Proceedings of the National Science Academy of the USA, 105, 16266-71. (Freely available online through the PNAS open-access option.)

    H. Christina Fan;Yair J. Blumenfeld;Usha Chitkara;Louanne Hudgins

Frequent Co-Authors

Axel Scherer
Axel Scherer California Institute of Technology
Liqun Luo
Liqun Luo Stanford University
Michael F. Clarke
Michael F. Clarke Stanford University
Irving L. Weissman
Irving L. Weissman Stanford University
Gary M. Shaw
Gary M. Shaw Stanford University
David A. Relman
David A. Relman Stanford University
Mark M. Davis
Mark M. Davis Stanford University
Tony Wyss-Coray
Tony Wyss-Coray Stanford University
David K. Stevenson
David K. Stevenson Stanford University

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