World's Best Scientists 2026 revealed!
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Molecular Biology
USA
2026

D-Index & Metrics

Molecular Biology

D-Index
163
Citations
145637
World Ranking
58
National Ranking
39

Research.com Recognitions

  • 2026 - Research.com Molecular Biology in United States Leader Award
  • 2025 - Research.com Molecular Biology in United States Leader Award
  • 2023 - Research.com Molecular Biology in United States Leader Award
  • 2020 - Fellow of the American Academy of Arts and Sciences
  • 2020 - Member of the National Academy of Sciences
  • 2017 - Member of the National Academy of Medicine (NAM)
  • 2015 - Paul Marks Prize for Cancer Research, Memorial Sloan Kettering Cancer Center
  • 1992 - Fellow of the Indian National Academy of Engineering (INAE)

Overview

Howard Y. Chang is affiliated with Stanford University in the United States. Their scholarly contributions span several fields related to biochemistry, genetics, molecular biology, and medicine, with a particular focus on molecular biology, cancer research, immunology, oncology, and genetics.

Their research topics cover a broad range of areas, including cancer genomics and diagnostics, genomics and chromatin dynamics, single-cell and spatial transcriptomics, RNA modifications and cancer, RNA research and splicing, epigenetics and DNA methylation, and CRISPR and genetic engineering.

Coauthors frequently collaborating with Howard Y. Chang include:

  • Paul S. Mischel
  • Vineet Bafna
  • Ansuman T. Satpathy
  • Kathryn E. Yost
  • Jens Luebeck

Some of the major publication venues for the scientist's work include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Genetics
  • Nature
  • Nature Communications
  • Cancer Research

Notable recent papers authored or coauthored by Howard Y. Chang are:

  • Long non-coding RNAs: definitions, functions, challenges and recommendations, 2023, Nature Reviews Molecular Cell Biology
  • CRISPR-engineered T cells in patients with refractory cancer, 2020, Science
  • ArchR is a scalable software package for integrative single-cell chromatin accessibility analysis, 2021, Nature Genetics
  • Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing, 2021, Cell
  • Extrachromosomal DNA is associated with oncogene amplification and poor outcome across multiple cancers, 2020, Nature Genetics

Howard Y. Chang has been recognized with several awards, including:

  • Fellow of the American Academy of Arts and Sciences, 2020
  • Member of the National Academy of Sciences, 2020
  • Member of the National Academy of Medicine (NAM), 2017
  • Paul Marks Prize for Cancer Research, Memorial Sloan Kettering Cancer Center, 2015
  • Fellow of the Indian National Academy of Engineering (INAE), 1992

Best Publications

  • Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position

    Jason D Buenrostro;Paul G Giresi;Lisa C Zaba;Howard Y Chang

  • Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis

    Rajnish A. Gupta;Nilay R. Shah;Kevin C. Wang;Jeewon Kim

  • Functional Demarcation of Active and Silent Chromatin Domains in Human HOX Loci by Noncoding RNAs

    John L. Rinn;Michael Kertesz;Jordon K. Wang;Sharon L. Squazzo

  • Molecular Mechanisms of Long Noncoding RNAs

    Kevin C. Wang;Howard Y. Chang

  • Genome Regulation by Long Noncoding RNAs

    John L. Rinn;Howard Y. Chang

  • Long Noncoding RNA as Modular Scaffold of Histone Modification Complexes

    Miao-Chih Tsai;Ohad Manor;Yue Wan;Nima Mosammaparast

  • Unique features of long non-coding RNA biogenesis and function

    Jeffrey J. Quinn;Howard Y. Chang

  • ATAC-seq: A Method for Assaying Chromatin Accessibility Genome-Wide

    Jason D. Buenrostro;Beijing Wu;Howard Y. Chang;William J. Greenleaf

  • Long Noncoding RNAs in Cancer Pathways

    Adam M. Schmitt;Howard Y. Chang

  • Long Noncoding RNAs: Cellular Address Codes in Development and Disease

    Pedro J. Batista;Howard Y. Chang

  • A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression

    Kevin C. Wang;Yul W. Yang;Bo Liu;Amartya Sanyal

  • Long noncoding RNAs and human disease

    Orly Wapinski;Howard Y. Chang

  • Single-cell chromatin accessibility reveals principles of regulatory variation

    Jason D. Buenrostro;Beijing Wu;Ulrike M. Litzenburger;Dave Ruff

  • An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues

    M Ryan Corces;Alexandro E Trevino;Emily G Hamilton;Peyton G Greenside

  • Diversity, topographic differentiation, and positional memory in human fibroblasts

    Howard Y. Chang;Jen-Tsan Chi;Sandrine Dudoit;Chanda Bondre

  • Genomic maps of long noncoding RNA occupancy reveal principles of RNA-chromatin interactions.

    Ci Chu;Kun Qu;Franklin L. Zhong;Steven E. Artandi

  • Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters

    Tiffany Hung;Yulei Wang;Michael F. Lin;Michael F. Lin;Ashley K. Koegel

  • Daxx, a novel fas-binding protein that activates jnk and apoptosis

    Xiaolu Yang;Roya Khosravi-Far;Howard Y. Chang;David Baltimore

  • SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin

    Eriko Michishita;Ronald A. McCord;Elisabeth Berber;Mitomu Kioi

  • Robustness, scalability, and integration of a wound-response gene expression signature in predicting breast cancer survival

    Howard Y. Chang;Dimitry S. A. Nuyten;Julie B. Sneddon;Trevor Hastie

Frequent Co-Authors

William J. Greenleaf
William J. Greenleaf Stanford University
Ansuman T. Satpathy
Ansuman T. Satpathy Stanford University
Paul A. Khavari
Paul A. Khavari Stanford University
Jason D. Buenrostro
Jason D. Buenrostro Harvard University
John L. Rinn
John L. Rinn University of Colorado Boulder
Michael T. Longaker
Michael T. Longaker Stanford University
Eran Segal
Eran Segal Weizmann Institute of Science
Marius Wernig
Marius Wernig Stanford University
Michael Snyder
Michael Snyder Stanford University
Anshul Kundaje
Anshul Kundaje Stanford University

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