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Biology and Biochemistry

D-Index
76
Citations
58226
World Ranking
4909
National Ranking
2356

Overview

Marius Wernig is a researcher affiliated with Stanford University in the United States. Their work spans multiple domains within biochemistry, genetics, and molecular biology, with significant contributions also in neuroscience. The scientist's research encompasses both broad and specialized fields, including molecular biology, neurology, cellular and molecular neuroscience, immunology, and genetics.

The main topics addressed in their publications cover pluripotent stem cells research, neuroinflammation and neurodegeneration mechanisms, CRISPR and genetic engineering, immune cells in cancer, genomics and chromatin dynamics, Alzheimer's disease research and treatments, and genetics and neurodevelopmental disorders.

Wernig has contributed to a range of notable scientific journals and publication venues. Frequent outlets for their research findings include bioRxiv (Cold Spring Harbor Laboratory), Nature, Nature Cell Biology, Molecular Cell, and Stem Cell Reports.

The following recent papers illustrate the variety of Wernig's work:

  • Restoring hippocampal glucose metabolism rescues cognition across Alzheimer's disease pathologies, 2024, Science
  • Cdk1 Controls Global Epigenetic Landscape in Embryonic Stem Cells, 2020, Molecular Cell
  • Treatment of a genetic brain disease by CNS-wide microglia replacement, 2022, Science Translational Medicine
  • H3.3-K27M drives neural stem cell-specific gliomagenesis in a human iPSC-derived model, 2021, Cancer Cell
  • Transition to a mesenchymal state in neuroblastoma confers resistance to anti-GD2 antibody via reduced expression of ST8SIA1, 2022, Nature Cancer

Collaboration has been a feature of Wernig's research career. Frequent co-authors include:

  • Thomas C. Südhof
  • Marius Marc-Daniel Mader
  • Yongjin Yoo
  • Yohei Shibuya
  • Jinzhao Wang

Their scientific output reflects a focus on mechanisms underlying stem cells, neurodegeneration, brain diseases, cancer, and genetic regulation at the molecular level. This is supported by a consistent record of publications in high-impact journals with interdisciplinary relevance.

Best Publications

  • A Bivalent Chromatin Structure Marks Key Developmental Genes in Embryonic Stem Cells

    Bradley E. Bernstein;Tarjei S. Mikkelsen;Tarjei S. Mikkelsen;Xiaohui Xie;Michael Kamal

  • Genome-wide maps of chromatin state in pluripotent and lineage-committed cells

    Tarjei S. Mikkelsen;Manching Ku;Manching Ku;David B. Jaffe;Biju Issac;Biju Issac

  • Direct conversion of fibroblasts to functional neurons by defined factors

    Thomas Vierbuchen;Austin Ostermeier;Zhiping P. Pang;Yuko Kokubu

  • In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state

    Marius Wernig;Alexander Meissner;Ruth Foreman;Tobias Brambrink

  • Polycomb complexes repress developmental regulators in murine embryonic stem cells

    Laurie A. Boyer;Kathrin Plath;Kathrin Plath;Julia Zeitlinger;Tobias Brambrink

  • Genome-scale DNA methylation maps of pluripotent and differentiated cells

    Alexander Meissner;Tarjei S. Mikkelsen;Tarjei S. Mikkelsen;Hongcang Gu;Marius Wernig

  • In vitro differentiation of transplantable neural precursors from human embryonic stem cells

    Su-Chun Zhang;Marius Wernig;Ian D. Duncan;Oliver Brüstle

  • Treatment of Sickle Cell Anemia Mouse Model with iPS Cells Generated from Autologous Skin

    Jacob Hanna;Marius Wernig;Marius Wernig;Styliani Markoulaki;Styliani Markoulaki;Chiao-Wang Sun;Chiao-Wang Sun

  • Rapid Single-Step Induction of Functional Neurons from Human Pluripotent Stem Cells

    Yingsha Zhang;Chang Hui Pak;Yan Han;Henrik Ahlenius

  • Dissecting direct reprogramming through integrative genomic analysis

    Tarjei S. Mikkelsen;Jacob Hanna;Xiaolan Zhang;Manching Ku

  • Connecting microrna genes to the core transcriptional regulatory circuitry of embryonic stem cells

    Rudolph Jaenisch;Richard A. Young;Alexander Marson;Stuart Levine

  • Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease

    Marius Wernig;Jian Ping Zhao;Jan Pruszak;Eva Hedlund

  • Induction of human neuronal cells by defined transcription factors

    Zhiping P. Pang;Nan Yang;Thomas Vierbuchen;Austin Ostermeier

  • m6A RNA Modification Controls Cell Fate Transition in Mammalian Embryonic Stem Cells

    Pedro J. Batista;Benoit Molinie;Jinkai Wang;Kun Qu

  • Direct Reprogramming of Terminally Differentiated Mature B Lymphocytes to Pluripotency

    Jacob Hanna;Styliani Markoulaki;Patrick Schorderet;Bryce W. Carey

  • Sequential Expression of Pluripotency Markers during Direct Reprogramming of Mouse Somatic Cells

    Tobias Brambrink;Ruth K. Foreman;G. Grant Welstead;Christopher Joachim Lengner

  • Direct reprogramming of genetically unmodified fibroblasts into pluripotent stem cells

    Alexander Meissner;Marius Wernig;Rudolf Jaenisch

  • c-Myc Is Dispensable for Direct Reprogramming of Mouse Fibroblasts

    Marius Wernig;Alexander Meissner;John P. Cassady;Rudolf Jaenisch

  • Hierarchical mechanisms for direct reprogramming of fibroblasts to neurons.

    Orly L. Wapinski;Thomas Vierbuchen;Kun Qu;Qian Yi Lee

  • Erratum: Dissecting direct reprogramming through integrative genomic analysis

    Tarjei S. Mikkelsen;Jacob Hanna;Xiaolan Zhang;Manching Ku

Frequent Co-Authors

Thomas C. Südhof
Thomas C. Südhof Stanford University
Howard Y. Chang
Howard Y. Chang Amgen (United States)
Alexander Meissner
Alexander Meissner Max Planck Institute for Molecular Genetics
Jacob H. Hanna
Jacob H. Hanna Weizmann Institute of Science
Bradley E. Bernstein
Bradley E. Bernstein Broad Institute
Konrad Hochedlinger
Konrad Hochedlinger Harvard University
Oliver Brüstle
Oliver Brüstle University Hospital Bonn
Tarjei S. Mikkelsen
Tarjei S. Mikkelsen Arsenal Biosciences (United States)
Eric S. Lander
Eric S. Lander Broad Institute

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