World's Best Scientists 2026 revealed!

D-Index & Metrics

Molecular Biology

D-Index
76
Citations
22124
World Ranking
1148
National Ranking
88

Research.com Recognitions

  • 2009 - German National Academy of Sciences Leopoldina - Deutsche Akademie der Naturforscher Leopoldina – Nationale Akademie der Wissenschaften Human Genetics and Molecular Medicine
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Oliver Brüstle is affiliated with the University Hospital Bonn in Germany and has a research focus spanning various aspects of molecular biology and neuroscience. Their work encompasses the study of pluripotent stem cells, neuroinflammation, genetic engineering, and neural dynamics.

The scientist's main fields of study include:

  • Biochemistry, Genetics and Molecular Biology
  • Neuroscience

Within these fields, their research spans several subfields such as:

  • Molecular Biology
  • Cellular and Molecular Neuroscience
  • Cognitive Neuroscience
  • Neurology
  • Physiology

Key topics covered in their publications include:

  • Neuroscience and Neural Engineering
  • Pluripotent Stem Cells Research
  • CRISPR and Genetic Engineering
  • Ion channel regulation and function
  • Pain Mechanisms and Treatments
  • Neural dynamics and brain function
  • Neuroinflammation and Neurodegeneration Mechanisms

Oliver Brüstle has frequently published in the following venues:

  • Glia
  • Frontiers in Bioengineering and Biotechnology
  • Frontiers in Cellular Neuroscience
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Neuroscience

Their recent published papers include:

  • "Deletion of Alzheimer's disease-associated CD33 results in an inflammatory human microglia phenotype," 2021, Glia
  • "Transcription Factor-Based Fate Specification and Forward Programming for Neural Regeneration," 2020, Frontiers in Cellular Neuroscience
  • "The StemCellFactory: A Modular System Integration for Automated Generation and Expansion of Human Induced Pluripotent Stem Cells," 2020, Frontiers in Bioengineering and Biotechnology
  • "Anthrax toxins regulate pain signaling and can deliver molecular cargoes into ANTXR2+ DRG sensory neurons," 2021, Nature Neuroscience
  • "Impact of Zika Virus Infection on Human Neural Stem Cell MicroRNA Signatures," 2020, Viruses

Frequent co-authors include:

  • Michael Peitz
  • Simone Haupt
  • Pascal Röderer
  • Tamara Krutenko
  • Mona Mathews

Recognition of Oliver Brüstle's contributions to science includes their election to the German National Academy of Sciences Leopoldina in 2009, with a focus on Human Genetics and Molecular Medicine. They are also a member of the European Molecular Biology Organization (EMBO).

Best Publications

  • In vitro differentiation of transplantable neural precursors from human embryonic stem cells

    Su-Chun Zhang;Marius Wernig;Ian D. Duncan;Oliver Brüstle

  • Embryonic Stem Cell-Derived Glial Precursors: A Source of Myelinating Transplants

    Oliver Brüstle;Kimberly N. Jones;Kimberly N. Jones;Randall D. Learish;Khalad Karram

  • Copy number variation and selection during reprogramming to pluripotency

    Samer M. Hussein;Nizar N. Batada;Sanna Vuoristo;Reagan W. Ching

  • A rosette-type, self-renewing human ES cell-derived neural stem cell with potential for in vitro instruction and synaptic integration

    Philipp Koch;Thoralf Opitz;Julius A. Steinbeck;Julia Ladewig

  • Direct Conversion of Fibroblasts into Stably Expandable Neural Stem Cells

    Marc Thier;Philipp Wörsdörfer;Yenal B. Lakes;Raphaela Gorris

  • Sirt1 contributes critically to the redox-dependent fate of neural progenitors

    Timour Prozorovski;Ulf Schulze-Topphoff;Robert Glumm;Jan Baumgart

  • Systemic administration of epothilone B promotes axon regeneration after spinal cord injury

    Jörg Ruschel;Farida Hellal;Kevin C. Flynn;Sebastian Dupraz

  • In vitro-Generated Neural Precursors Participate in Mammalian Brain Development

    O. Brustle;A. C. Spiro;K. Karram;K. Choudhary

  • Chimeric brains generated by intraventricular transplantation of fetal human brain cells into embryonic rats

    Oliver Brüstle;Oliver Brüstle;Oliver Brüstle;Khalid Choudhary;Khalid Choudhary;Khalad Karram;Khalad Karram;Khalad Karram;Anita Hüttner;Anita Hüttner

  • Small molecules enable highly efficient neuronal conversion of human fibroblasts

    Julia Ladewig;Jerome Mertens;Jaideep Kesavan;Jonas Doerr

  • Excitation-induced ataxin-3 aggregation in neurons from patients with Machado-Joseph disease.

    Philipp Koch;Peter Breuer;Michael Peitz;Johannes Jungverdorben

  • Human Induced Pluripotent Stem Cells form Functional Neurons and Improve Recovery After Grafting in Stroke-Damaged Brain.

    Koichi Oki;Jemal Tatarishvili;James Wood;Philipp Koch

  • High-resolution DNA analysis of human embryonic stem cell lines reveals culture-induced copy number changes and loss of heterozygosity.

    Elisa Närvä;Reija Autio;Reija Autio;Nelly Rahkonen;Lingjia Kong

  • Capture of neuroepithelial-like stem cells from pluripotent stem cells provides a versatile system for in vitro production of human neurons

    Anna Falk;Philipp Koch;Jaideep Kesavan;Yasuhiro Takashima

  • Re-expression of the intermediate filament nestin in reactive astrocytes

    R.C.S. Lin;D.F. Matesic;M. Marvin;R.D.G. McKay

  • Host-guided migration allows targeted introduction of neurons into the embryonic brain

    Oliver Brüstle;Uwe Maskos;Ronald D.G. McKay

  • Induction of pluripotency in adult unipotent germline stem cells.

    Kinarm Ko;Natalia Tapia;Guangming Wu;Jeong Beom Kim

  • Inhibition of Notch Signaling in Human Embryonic Stem Cell–Derived Neural Stem Cells Delays G1/S Phase Transition and Accelerates Neuronal Differentiation In Vitro and In Vivo

    Lodovica Borghese;Dasa Dolezalova;Thoralf Opitz;Simone Haupt

  • Leveling Waddington: the emergence of direct programming and the loss of cell fate hierarchies

    Julia Ladewig;Philipp Koch;Oliver Brüstle

  • Human induced pluripotent stem cell-derived cortical neurons integrate in stroke-injured cortex and improve functional recovery.

    Daniel Tornero;Somsak Wattananit;Marita Grønning Madsen;Philipp Koch

Frequent Co-Authors

Ronald D. G. McKay
Ronald D. G. McKay Lieber Institute for Brain Development
Joseph Itskovitz-Eldor
Joseph Itskovitz-Eldor Technion – Israel Institute of Technology
Alfredo Ramirez
Alfredo Ramirez University of Cologne
Marius Wernig
Marius Wernig Stanford University
Olle Lindvall
Olle Lindvall Lund University
Heinz Beck
Heinz Beck University of Bonn
Otmar D. Wiestler
Otmar D. Wiestler German Cancer Research Center
Peter Wernet
Peter Wernet Heinrich Heine University Düsseldorf
Zaal Kokaia
Zaal Kokaia Lund University
Stefan Herms
Stefan Herms University of Basel

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