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William J. Greenleaf

William J. Greenleaf

D-Index & Metrics

Genetics

D-Index
82
Citations
46982
World Ranking
1445
National Ranking
679

Research.com Recognitions

  • 1964 - Fellow of John Simon Guggenheim Memorial Foundation

Overview

William J. Greenleaf is affiliated with Stanford University in the United States. Their research focuses primarily on biochemistry, genetics, and molecular biology, with significant contributions to the fields of molecular biology, immunology, cancer research, genetics, and oncology.

The scientist's work centers around key topics such as genomics and chromatin dynamics, single-cell and spatial transcriptomics, RNA research and splicing, RNA and protein synthesis mechanisms, epigenetics and DNA methylation, cancer genomics and diagnostics, and RNA modifications related to cancer.

Among recent papers authored or co-authored by William J. Greenleaf are the following:

  • ArchR is a scalable software package for integrative single-cell chromatin accessibility analysis, 2021, Nature Genetics
  • Chromatin and gene-regulatory dynamics of the developing human cerebral cortex at single-cell resolution, 2021, Cell
  • Single-cell epigenomic analyses implicate candidate causal variants at inherited risk loci for Alzheimer's and Parkinson's diseases, 2020, Nature Genetics
  • Single-cell analyses define a continuum of cell state and composition changes in the malignant transformation of polyps to colorectal cancer, 2022, Nature Genetics
  • PD-1 combination therapy with IL-2 modifies CD8+ T cell exhaustion program, 2022, Nature

Frequent co-authors of William J. Greenleaf include:

  • Anshul Kundaje
  • Georgi K. Marinov
  • Howard Y. Chang
  • M Snyder
  • Christina Curtis

Publications by this researcher are often found in the following venues:

  • ENCODE Datasets
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Genetics
  • Cell
  • Nature

William J. Greenleaf's career includes recognition such as being named a Fellow of the John Simon Guggenheim Memorial Foundation in 1964.

Best Publications

  • Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position

    Jason D Buenrostro;Paul G Giresi;Lisa C Zaba;Howard Y Chang

  • ATAC-seq: A Method for Assaying Chromatin Accessibility Genome-Wide

    Jason D. Buenrostro;Beijing Wu;Howard Y. Chang;William J. Greenleaf

  • Single-cell chromatin accessibility reveals principles of regulatory variation

    Jason D. Buenrostro;Beijing Wu;Ulrike M. Litzenburger;Dave Ruff

  • An improved ATAC-seq protocol reduces background and enables interrogation of frozen tissues

    M Ryan Corces;Alexandro E Trevino;Emily G Hamilton;Peyton G Greenside

  • Chromatin accessibility and the regulatory epigenome.

    Sandy L Klemm;Zohar Shipony;William J Greenleaf

  • chromVAR: inferring transcription-factor-associated accessibility from single-cell epigenomic data

    Alicia N Schep;Beijing Wu;Jason D Buenrostro;William J Greenleaf

  • Lineage-specific and single-cell chromatin accessibility charts human hematopoiesis and leukemia evolution

    M Ryan Corces;Jason D Buenrostro;Jason D Buenrostro;Beijing Wu;Peyton G Greenside

  • Massively parallel single-cell chromatin landscapes of human immune cell development and intratumoral T cell exhaustion.

    Ansuman T. Satpathy;Jeffrey M. Granja;Kathryn E. Yost;Yanyan Qi

  • Direct observation of base-pair stepping by RNA polymerase

    Elio A. Abbondanzieri;William J. Greenleaf;Joshua W. Shaevitz;Robert Landick

  • HiChIP: efficient and sensitive analysis of protein-directed genome architecture.

    Maxwell R Mumbach;Adam J Rubin;Ryan A Flynn;Chao Dai

  • The chromatin accessibility landscape of primary human cancers

    M. Ryan Corces;Jeffrey M. Granja;Shadi Shams;Bryan H. Louie

  • ArchR is a scalable software package for integrative single-cell chromatin accessibility analysis.

    Jeffrey M. Granja;M. Ryan Corces;Sarah E. Pierce;S. Tansu Bagdatli

  • Integrated Single-Cell Analysis Maps the Continuous Regulatory Landscape of Human Hematopoietic Differentiation

    Jason D. Buenrostro;Jason D. Buenrostro;M. Ryan Corces;Caleb A. Lareau;Caleb A. Lareau;Beijing Wu

  • High-resolution, single-molecule measurements of biomolecular motion.

    William J. Greenleaf;Michael T. Woodside;Steven M. Block

  • The Human Tumor Atlas Network: Charting Tumor Transitions Across Space and Time at Single-Cell Resolution

    Orit Rozenblatt-Rosen;Aviv Regev;Aviv Regev;Aviv Regev;Philipp Oberdoerffer;Tal Nawy

  • Origin and differentiation of human memory CD8 T cells after vaccination

    Rama Akondy;Mark Fitch;Srilatha Edupuganti;Shu Yang

  • Enhancer connectome in primary human cells identifies target genes of disease-associated DNA elements

    Maxwell R Mumbach;Ansuman T Satpathy;Evan A Boyle;Chao Dai

  • ARTIFICIAL CAVITATION NUCLEI SIGNIFICANTLY ENHANCE ACOUSTICALLY INDUCED CELL TRANSFECTION

    William J. Greenleaf;Mark E. Bolander;Gobinda Sarkar;Mary B. Goldring

  • Single-cell multiomic analysis identifies regulatory programs in mixed-phenotype acute leukemia

    Jeffrey M. Granja;Sandy Klemm;Lisa M. McGinnis;Arwa S. Kathiria

  • The human body at cellular resolution: the NIH Human Biomolecular Atlas Program

    Michael P. Snyder;Shin Lin

Frequent Co-Authors

Howard Y. Chang
Howard Y. Chang Amgen (United States)
Jason D. Buenrostro
Jason D. Buenrostro Harvard University
Anshul Kundaje
Anshul Kundaje Stanford University
Paul A. Khavari
Paul A. Khavari Stanford University
Michael Snyder
Michael Snyder Stanford University
Ansuman T. Satpathy
Ansuman T. Satpathy Stanford University
Steven M. Block
Steven M. Block Stanford University
Rhiju Das
Rhiju Das Stanford University
Jonathan K. Pritchard
Jonathan K. Pritchard Stanford University
Daniel Herschlag
Daniel Herschlag Stanford University

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