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Genetics

D-Index
85
Citations
28972
World Ranking
1303
National Ranking
621

Research.com Recognitions

  • 2008 - Member of the National Academy of Sciences
  • 2006 - Fellow of the American Academy of Arts and Sciences
  • 2001 - Fellow of the American Association for the Advancement of Science (AAAS)

Overview

Michael R. Botchan is affiliated with the University of California, Berkeley in the United States. Their research primarily focuses on fields related to Biochemistry, Genetics, and Molecular Biology, with a specific emphasis on Molecular Biology. Their work encompasses several topics including Genomics and Chromatin Dynamics, DNA Repair Mechanisms, DNA and Nucleic Acid Chemistry, RNA Research and Splicing, and RNA and protein synthesis mechanisms.

The scientist has contributed to various studies published in notable venues. Recent papers include:

  • Structural Mechanisms for Replicating DNA in Eukaryotes, 2021, Annual Review of Biochemistry
  • Molecular determinants of phase separation for Drosophila DNA replication licensing factors, 2021, bioRxiv (Cold Spring Harbor Laboratory)

Frequent co-authors collaborating with Michael R. Botchan comprise:

  • James M. Berger
  • Ilan Attali
  • Matthew W. Parker
  • Jonchee A. Kao
  • Alvin Huang

The scientist's work has appeared especially in the Annual Review of Biochemistry and in bioRxiv (Cold Spring Harbor Laboratory).

Recognition for their contributions includes several awards:

  • Member of the National Academy of Sciences, 2008
  • Fellow of the American Academy of Arts and Sciences, 2006
  • Fellow of the American Association for the Advancement of Science (AAAS), 2001

Best Publications

  • The genome sequence of Drosophila melanogaster

    M. D. Adams;S. E. Celniker;R. A. Holt;C. A. Evans

  • A prudent path forward for genomic engineering and germline gene modification

    David Baltimore;Paul Berg;Michael Botchan;Dana Carroll

  • Isolation of the Cdc45/Mcm2–7/GINS (CMG) complex, a candidate for the eukaryotic DNA replication fork helicase

    Stephen E. Moyer;Peter W. Lewis;Michael R. Botchan

  • Inhibition of SV40 replication in simian cells by specific pBR322 DNA sequences.

    Monika Lusky;Michael Botchan

  • The arrangement of simian virus 40 sequences in the DNA of transformed cells

    Michael Botchan;William Topp;Joe Sambrook

  • Activation of the MCM2-7 helicase by association with Cdc45 and GINS proteins.

    Ivar Ilves;Tatjana Petojevic;Tatjana Petojevic;James J. Pesavento;Michael R. Botchan

  • Targeting the E1 replication protein to the papillomavirus origin of replication by complex formation with the E2 transactivator.

    Ian J. Mohr;Robin Clark;Shaw Sun;Elliot J. Androphy

  • Association of the Origin Recognition Complex with Heterochromatin and HP1 in Higher Eukaryotes

    Daniel T.S Pak;Michelle Pflumm;Igor Chesnokov;Da Wei Huang

  • High mutation frequency in DNA transfected into mammalian cells

    Michele P. Calos;Jane S. Lebkowski;Michael R. Botchan

  • Activation of BPV-1 replication in vitro by the transcription factor E2.

    Liu Yang;Rong Li;Ian J. Mohr;Robin Clark

  • Direct interaction between Sp1 and the BPV enhancer E2 protein mediates synergistic activation of transcription

    Rong Li;Jonathan D. Knight;Stephen P. Jackson;Robert Tjian

  • Zelda binding in the early Drosophila melanogaster embryo marks regions subsequently activated at the maternal-to-zygotic transition.

    Melissa M. Harrison;Xiao-Yong Li;Tommy Kaplan;Tommy Kaplan;Michael R. Botchan

  • The structural basis for MCM2-7 helicase activation by GINS and Cdc45.

    Alessandro Costa;Ivar Ilves;Nele Tamberg;Tatjana Petojevic;Tatjana Petojevic

  • The E1 protein of bovine papilloma virus 1 is an ATP-dependent DNA helicase

    Liu Yang;Ian Mohr;Erik Fouts;Daniel A. Lim

  • The retinoblastoma gene product regulates Sp1-mediated transcription

    Seong Jin Kim;Uche S. Onwuta;Young Ik Lee;Rong Li

  • Identification of a Drosophila Myb-E2F2/RBF transcriptional repressor complex

    Peter W. Lewis;Eileen L. Beall;Tracey C. Fleischer;Daphne Georlette

  • DNA topology, not DNA sequence, is a critical determinant for Drosophila ORC–DNA binding

    Dirk Remus;Eileen L Beall;Michael R Botchan

  • Characterization of the Bovine Papilloma virus plasmid maintenance sequences

    Monika Lusky;Michael R. Botchan

  • Role for a Drosophila Myb-containing protein complex in site-specific DNA replication

    Eileen L. Beall;J. Robert Manak;Sharleen Zhou;Maren Bell

  • Bovine papilloma virus contains an activator of gene expression at the distal end of the early transcription unit.

    M Lusky;L Berg;H Weiher;M Botchan

Frequent Co-Authors

James M. Berger
James M. Berger Johns Hopkins University
Eva Nogales
Eva Nogales University of California, Berkeley
Joseph Sambrook
Joseph Sambrook The University of Texas Southwestern Medical Center
John E. Hearst
John E. Hearst University of California, Berkeley
Manfred Gossen
Manfred Gossen Charité - University Medicine Berlin
Xavier Darzacq
Xavier Darzacq University of California, Berkeley
James R. Stringer
James R. Stringer University of Cincinnati
Dana Carroll
Dana Carroll University of Utah
Michael B. Eisen
Michael B. Eisen University of California, Berkeley

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