World's Best Scientists 2026 revealed!
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Microbiology
Portugal
2026

D-Index & Metrics

Microbiology

D-Index
65
Citations
21006
World Ranking
2470
National Ranking
7

Research.com Recognitions

  • 2026 - Research.com Microbiology in Portugal Leader Award
  • 2008 - Member of Academia Europaea
  • 1995 - Fellow of the Royal Society, United Kingdom
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Jonathan C. Howard is affiliated with the Instituto Gulbenkian de Ciência in Portugal. Their research spans multiple disciplines within biochemistry, genetics, molecular biology, and medicine, with a primary focus on molecular biology, parasitology, molecular medicine, infectious diseases, and epidemiology.

The scientist has contributed extensively to topics including inflammasome and immune disorders, Toxoplasma gondii research studies, antibiotic resistance in bacteria, antimicrobial resistance in Staphylococcus, parasitic infections and diagnostics, cytomegalovirus and herpesvirus research, as well as RNA modifications and cancer.

Jonathan C. Howard's frequent coauthors include:

  • Masahiro Yamamoto
  • Elif Eren
  • Rémi Planès
  • Salimata Bagayoko
  • Pierre-Jean Bordignon

Common publication venues where their work appears are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • EMBO Reports
  • PLoS Pathogens
  • Cell Reports
  • Nature Immunology

Among the recent papers authored or coauthored by Jonathan C. Howard are:

  • "Irgm2 and Gate-16 cooperatively dampen Gram-negative bacteria-induced caspase-11 response" (2020, EMBO Reports)
  • "ROP39 is an Irgb10-specific parasite effector that modulates acute Toxoplasma gondii virulence" (2023, PLoS Pathogens)
  • "Human TRMT1 and TRMT1L paralogs ensure the proper modification state, stability, and function of tRNAs" (2025, Cell Reports)
  • "Dual role of Toxoplasma gondii ROP5 and ROP18 for NLRP3 inhibition" (2023, bioRxiv - Cold Spring Harbor Laboratory)
  • "Irgm2 and Gate-16 cooperatively dampen targeting of caspase-11 to Gram-negative bacterial products" (2020, bioRxiv - Cold Spring Harbor Laboratory)

The scientist has been recognized with several honors including being named a Member of Academia Europaea in 2008, a Fellow of the Royal Society in the United Kingdom since 1995, and a member of the European Molecular Biology Organization (EMBO).

Best Publications

  • Cellular responses to interferon-gamma.

    U Boehm;T Klamp;M Groot;J C Howard

  • Antibodies to major histocompatibility antigens produced by hybrid cell lines.

    Galfre G;Galfre G;Howe Sc;Milstein C;Butcher Gw

  • MHC class II region encoding proteins related to the multidrug resistance family of transmembrane transporters.

    Edward V. Deverson;Irene R. Gow;W. John Coadwell;John J. Monaco

  • A class of iron chelators with a wide spectrum of potent antitumor activity that overcomes resistance to chemotherapeutics

    Megan Whitnall;Jonathan Howard;Prem Ponka;Des R. Richardson

  • Restoration of antigen presentation to the mutant cell line RMA-S by an MHC-linked transporter

    Simon J. Powis;Alain R. M. Townsend;Edward V. Deverson;Judy Bastin

  • Selectivity of MHC-encoded peptide transporters from human, mouse and rat

    Frank Momburg;Joost Roelse;Jonathan C. Howard;Geoffrey W. Butcher

  • Disruption of Toxoplasma gondii parasitophorous vacuoles by the mouse p47-resistance GTPases.

    Sascha Martens;Iana Parvanova;Jens Zerrahn;Gareth Griffiths

  • Effect of polymorphism of an MHC-linked transporter on the peptides assembled in a class I molecule

    Powis Sj;Deverson Ev;Coadwell Wj;Ciruela A;Ciruela A

  • The interferon-inducible p47 (IRG) GTPases in vertebrates: loss of the cell autonomous resistance mechanism in the human lineage

    Cemalettin Bekpen;Julia P Hunn;Christoph Rohde;Iana Parvanova

  • Phosphorylation of Mouse Immunity-Related GTPase (IRG) Resistance Proteins Is an Evasion Strategy for Virulent Toxoplasma gondii

    Tobias Steinfeldt;Stephanie Könen-Waisman;Lan Tong;Nikolaus Pawlowski

  • IDENTIFICATION OF MARROW-DERIVED AND THYMUS-DERIVED SMALL LYMPHOCYTES IN THE LYMPHOID TISSUE AND THORACIC DUCT LYMPH OF NORMAL RATS

    Jonathan C. Howard;S. V. Hunt;J. L. Gowans

  • Two families of GTPases dominate the complex cellular response to IFN-gamma.

    Ulrich Boehm;Lisbeth Guethlein;Thorsten Klamp;Kural Ozbek

  • Proteasome subunits encoded by the major histocompatibility complex are not essential for antigen presentation.

    Frank Momburg;Vianney Ortiz-Navarrete;Jacques Neefjes;Els Goulmy

  • Comparative Genomics of the Apicomplexan Parasites Toxoplasma gondii and Neospora caninum: Coccidia Differing in Host Range and Transmission Strategy

    Adam James Reid;Sarah J. Vermont;James A. Cotton;David Harris

  • Differentiation of Cytoplasmic and Meiotic Spindle Assembly MCAK Functions by Aurora B-dependent Phosphorylation

    Ryoma Ohi;Tanuj Sapra;Jonathan Howard;Timothy J. Mitchison

  • Disruption of the Toxoplasma gondii Parasitophorous Vacuole by IFNγ-Inducible Immunity-Related GTPases (IRG Proteins) Triggers Necrotic Cell Death

    Yang O. Zhao;Aliaksandr Khaminets;Julia P. Hunn;Jonathan C. Howard

  • A Toxoplasma gondii pseudokinase inhibits host IRG resistance proteins.

    Martin C. Fleckenstein;Michael L. Reese;Stephanie Könen-Waisman;John C. Boothroyd

  • THE LIFE-SPAN AND RECIRCULATION OF MARROW-DERIVED SMALL LYMPHOCYTES FROM THE RAT THORACIC DUCT

    Jonathan C. Howard

  • Coordinated loading of IRG resistance GTPases on to the Toxoplasma gondii parasitophorous vacuole.

    Aliaksandr Khaminets;Julia P. Hunn;Stephanie Könen-Waisman;Yang O. Zhao

  • The interferon-inducible GTPases.

    Sascha Martens;Jonathan Howard

  • The IRG protein-based resistance mechanism in mice and its relation to virulence in Toxoplasma gondii

    Jonathan C Howard;Julia P Hunn;Tobias Steinfeldt

  • Disease and evolution

    Howard Jc

Frequent Co-Authors

Sascha Martens
Sascha Martens University of Vienna
Gregory A. Taylor
Gregory A. Taylor Duke University
Matilde Inglese
Matilde Inglese University of Genoa
Darcy B. Wilson
Darcy B. Wilson Torrey Pines Institute For Molecular Studies
Ricardo T. Gazzinelli
Ricardo T. Gazzinelli Universidade Federal de Minas Gerais
Fred D. Lublin
Fred D. Lublin Icahn School of Medicine at Mount Sinai
Klaus Pfeffer
Klaus Pfeffer Heinrich Heine University Düsseldorf
Douglas F. Antczak
Douglas F. Antczak Cornell University
Joe Herbert
Joe Herbert University of Cambridge
L. David Sibley
L. David Sibley Washington University in St. Louis

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