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Biology and Biochemistry

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Citations
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Overview

Hiroyuki Araki is affiliated with the National Institute of Genetics in Japan. Their research spans multiple areas within biochemistry, genetics, and molecular biology, with particular emphasis on DNA repair mechanisms, CRISPR and genetic engineering, and related molecular processes.

The primary fields of study in Hiroyuki Araki's work include:

  • Biochemistry, Genetics and Molecular Biology

The research also delves into various specialized subfields such as:

  • Molecular Biology
  • Civil and Structural Engineering
  • Cancer Research
  • Organic Chemistry

Key topics investigated across publications are:

  • DNA Repair Mechanisms
  • CRISPR and Genetic Engineering
  • Carcinogens and Genotoxicity Assessment
  • Fungal and Yeast Genetics Research
  • Glycosylation and Glycoproteins Research
  • Ubiquitin and Proteasome Pathways
  • Carbohydrate Chemistry and Synthesis

Hiroyuki Araki has contributed to several peer-reviewed journals, including:

  • International Journal of Molecular Sciences
  • DNA Repair
  • The Journal of Organic Chemistry
  • International Journal of Geomate

Notable recent papers authored or co-authored by Araki include:

  • "Recombination and Pol ζ Rescue Defective DNA Replication upon Impaired CMG Helicase-Pol ε Interaction," 2020, International Journal of Molecular Sciences
  • "Increased contribution of DNA polymerase delta to the leading strand replication in yeast with an impaired CMG helicase complex," 2022, DNA Repair
  • "Chemical Synthesis of Ubiquitinated High-Mannose-Type N-Glycoprotein CCL1 in Different Folding States," 2020, The Journal of Organic Chemistry
  • "EFFECTS OF LIQUEFACTION COUNTERMEASURE USING BURIED GABION INSTALLED TO SHALLOW FOUNDATIONS," 2024, International Journal of Geomate

Frequent collaborators in their research include:

  • Milena Denkiewicz-Kruk
  • Malgorzata Jedrychowska
  • Michał Dmowski
  • Iwona J. Fijałkowska
  • Shizuko Endo

This combination of research topics and interdisciplinary collaboration reflects a focus on molecular and genetic mechanisms connected to DNA processing, synthesis, and repair, alongside applications relevant to structural engineering and organic chemistry.

Best Publications

  • CDK-dependent phosphorylation of Sld2 and Sld3 initiates DNA replication in budding yeast

    Seiji Tanaka;Toshiko Umemori;Kazuyuki Hirai;Sachiko Muramatsu

  • A yeast mitogen-activated protein kinase homolog (Mpk1p) mediates signalling by protein kinase C.

    K S Lee;K Irie;Y Gotoh;Y Watanabe

  • GINS, a novel multiprotein complex required for chromosomal DNA replication in budding yeast

    Yuko Takayama;Yoichiro Kamimura;Mariko Okawa;Sachiko Muramatsu

  • A third essential DNA polymerase in S. cerevisiae.

    Alan Morrison;Hiroyuki Araki;Alan B. Clark;Robert K. Hamatake

  • MKK1 and MKK2, which encode Saccharomyces cerevisiae mitogen-activated protein kinase-kinase homologs, function in the pathway mediated by protein kinase C.

    K Irie;M Takase;K S Lee;D E Levin

  • Dpb11, which interacts with DNA polymerase II(epsilon) in Saccharomyces cerevisiae, has a dual role in S-phase progression and at a cell cycle checkpoint

    Hiroyuki Araki;Sun-Hee Leem;Amornrat Phongdara;Akio Sugino

  • High-dimensional and large-scale phenotyping of yeast mutants

    Yoshikazu Ohya;Jim Sese;Masashi Yukawa;Fumi Sano

  • Sld3, which interacts with Cdc45 (Sld4), functions for chromosomal DNA replication in Saccharomyces cerevisiae.

    Yoichiro Kamimura;Yon‐Soo Tak;Akio Sugino;Hiroyuki Araki;Hiroyuki Araki;Hiroyuki Araki

  • CDK-dependent complex formation between replication proteins Dpb11, Sld2, Pol ɛ, and GINS in budding yeast

    Sachiko Muramatsu;Kazuyuki Hirai;Yon-Soo Tak;Yoichiro Kamimura

  • Origin Association of Sld3, Sld7, and Cdc45 Proteins Is a Key Step for Determination of Origin-Firing Timing

    Seiji Tanaka;Ryuichiro Nakato;Yuki Katou;Katsuhiko Shirahige

  • S-Cdk-dependent phosphorylation of Sld2 essential for chromosomal DNA replication in budding yeast

    Hiroshi Masumoto;Sachiko Muramatsu;Yoichiro Kamimura;Hiroyuki Araki;Hiroyuki Araki

  • A novel ring-like complex of Xenopus proteins essential for the initiation of DNA replication

    Yumiko Kubota;Youhei Takase;Yasunori Komori;Yoshitami Hashimoto

  • Dpb11 Controls the Association between DNA Polymerases α and ɛ and the Autonomously Replicating Sequence Region of Budding Yeast

    Hiroshi Masumoto;Akio Sugino;Hiroyuki Araki;Hiroyuki Araki;Hiroyuki Araki

  • Sld2, which interacts with Dpb11 in Saccharomyces cerevisiae, is required for chromosomal DNA replication.

    Yoichiro Kamimura;Hiroshi Masumoto;Akio Sugino;Hiroyuki Araki

  • DNA polymerase II, the probable homolog of mammalian DNA polymerase epsilon, replicates chromosomal DNA in the yeast Saccharomyces cerevisiae.

    H. Araki;P.A. Ropp;A.L. Johnson;L.H. Johnston

  • Molecular and functional organization of yeast plasmid pSR1

    Hiroyuki Araki;Amornrat Jearnpipatkul;Hiroki Tatsumi;Tohru Sakurai

  • Helicase Activation and Establishment of Replication Forks at Chromosomal Origins of Replication

    Seiji Tanaka;Hiroyuki Araki

  • Chromosome engineering in Saccharomyces cerevisiae by using a site-specific recombination system of a yeast plasmid.

    H Matsuzaki;R Nakajima;J Nishiyama;H Araki

  • Kinetochores Coordinate Pericentromeric Cohesion and Early DNA Replication by Cdc7-Dbf4 Kinase Recruitment

    Toyoaki Natsume;Carolin A. Müller;Yuki Katou;Renata Retkute

  • The product of the Saccharomyces cerevisiae cell cycle gene DBF2 has homology with protein kinases and is periodically expressed in the cell cycle.

    L H Johnston;S L Eberly;J W Chapman;H Araki

Frequent Co-Authors

Yasuji Oshima
Yasuji Oshima Osaka University
Akio Sugino
Akio Sugino Osaka University
Hideyuki Ogawa
Hideyuki Ogawa Osaka University
Kenji Irie
Kenji Irie University of Tsukuba
Katsuhiko Shirahige
Katsuhiko Shirahige University of Tokyo
Makkuni Jayaram
Makkuni Jayaram The University of Texas at Austin
Akio Toh-e
Akio Toh-e Chiba University
Yoshihide Kanaoka
Yoshihide Kanaoka Brigham and Women's Hospital
Youri I. Pavlov
Youri I. Pavlov University of Nebraska Medical Center
David E. Levin
David E. Levin Boston University

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