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Molecular Biology

D-Index
42
Citations
5961
World Ranking
3034
National Ranking
1438

Overview

Makkuni Jayaram is affiliated with The University of Texas at Austin in the United States. Their research primarily spans the fields of Biochemistry, Genetics, and Molecular Biology, with a focus on Molecular Biology, Plant Science, Genetics, Cardiology and Cardiovascular Medicine, and Epidemiology.

Their scientific contributions address multiple topics, including:

  • CRISPR and Genetic Engineering
  • Genomics and Chromatin Dynamics
  • RNA and Protein Synthesis Mechanisms
  • Plant Virus Research Studies
  • Congenital Heart Defects Research
  • Fungal and Yeast Genetics Research
  • DNA Repair Mechanisms

Jayaram's publication record includes several papers across various journals and preprint platforms. Notable recent works include:

  • "The selfish yeast plasmid utilizes the condensin complex and condensed chromatin for faithful partitioning," 2021, PLoS Genetics
  • "A bipartite thermodynamic-kinetic contribution by an activating mutation to RDF-independent excision by a phage serine integrase," 2020, Nucleic Acids Research
  • "Disintegration promotes protospacer integration by the Cas1-Cas2 complex," 2021, eLife
  • "The selfish yeast plasmid exploits a SWI/SNF-type chromatin remodeling complex for hitchhiking on chromosomes and ensuring high-fidelity propagation," 2023, PLoS Genetics
  • "Hitchhiking on condensed chromatin promotes plasmid persistence in yeast without perturbing chromosome function," 2020, bioRxiv (Cold Spring Harbor Laboratory)

Jayaram frequently collaborates with other researchers, especially:

  • Chien-Hui Ma
  • Deepanshu Kumar
  • Santanu Ghosh
  • David Wolfson
  • Joshua A. Hull

Their work has appeared most frequently in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • eLife
  • PLoS Genetics
  • Nucleic Acids Research
  • Tropical Biomedicine

Best Publications

  • Localization and sequence analysis of yeast origins of DNA replication.

    James Broach;Y. Y. Li;J. Feldman;M. Jayaram

  • Recombination within the yeast plasmid 2μ circle is site-specific

    James R. Broach;Vicki R. Guarascio;Makkuni Jayaram

  • DNA cleavage in trans by the active site tyrosine during Flp recombination: Switching protein partners before exchanging strands

    Jing Wen Chen;Jehee Lee;Makkuni Jayaram

  • The yeast plasmid 2μ circle encodes components required for its high copy propagation

    Makkuni Jayaram;Y. Y. Li;J. R. Broach

  • THE INTEGRASE FAMILY OF RECOMBINASES : ORGANIZATION AND FUNCTION OF THE ACTIVE SITE

    Ian Grainge;Makkuni Jayaram

  • DNA-protein complexes during attachment-site synapsis in Mu DNA transposition.

    Che Fu Kuo;Aihua Zou;Makkuni Jayaram;Elizabeth Getzoff

  • Vectors for high-level, inducible expression of cloned genes in yeast.

    James R. Broach;Yu-Yang Li;Ling-Chuan Chen Wu;Makkuni Jayaram

  • A general model for site-specific recombination by the integrase family recombinases

    Shailja Pathania;Makkuni Jayaram;Yuri Voziyanov

  • Path of DNA within the Mu transpososome. Transposase interactions bridging two Mu ends and the enhancer trap five DNA supercoils.

    Shailja Pathania;Makkuni Jayaram;Rasika M Harshey

  • Mechanisms for Chromosome and Plasmid Segregation

    Santanu Kumar Ghosh;Sujata Hajra;Andrew Paek;Makkuni Jayaram

  • Stepwise manipulation of DNA specificity in Flp recombinase: progressively adapting Flp to individual and combinatorial mutations in its target site.

    Yuri Voziyanov;Jay H. Konieczka;A. Francis Stewart;Makkuni Jayaram

  • Properties of REP3: a cis-acting locus required for stable propagation of the Saccharomyces cerevisiae plasmid 2 microns circle.

    Makkuni Jayaram;A. Sutton;J. R. Broach

  • Identification of the active site tyrosine of Flp recombinase: Possible relevance of its location to the mechanism of recombination

    Barbara R. Evans;Jing Wen Chen;Ronald L. Parsons;Tamara K. Bauer

  • Site-specific recombinase, R, encoded by yeast plasmid pSR1

    Hiroyuki Araki;Noriyuki Nakanishi;Barbara R. Evans;Hiroaki Matsuzaki

  • Functional analysis of Arg-308 mutants of Flp recombinase. Possible role of Arg-308 in coupling substrate binding to catalysis.

    Ronald L. Parsons;Barbara R. Evans;Lei Zheng;Makkuni Jayaram

  • Step-arrest Mutants of Phage Mu Transposase IMPLICATIONS IN DNA-PROTEIN ASSEMBLY, Mu END CLEAVAGE, AND STRAND TRANSFER

    Keetae Kim;Soon Young Namgoong;Makkuni Jayaram;Rasika M. Harshey

  • The 2 micron plasmid of Saccharomyces cerevisiae: a miniaturized selfish genome with optimized functional competence.

    Keng Ming Chan;Yen Ting Liu;Chien Hui Ma;Makkuni Jayaram

  • The 2 micron plasmid purloins the yeast cohesin complex: a mechanism for coupling plasmid partitioning and chromosome segregation?

    Shwetal Mehta;Xian Mei Yang;Clarence S. Chan;Melanie J. Dobson

  • Holliday junctions in FLP recombination: resolution by step-arrest mutants of FLP protein.

    Makkuni Jayaram;Karen L. Crain;Ronald L. Parsons;Rasika M. Harshey

  • Partitioning of the 2-μm Circle Plasmid of Saccharomyces cerevisiae: Functional Coordination with Chromosome Segregation and Plasmid-Encoded Rep Protein Distribution

    Soundarapandian Velmurugan;Xian Mei Yang;Clarence S.M. Chan;Melanie Dobson

Frequent Co-Authors

Jehee Lee
Jehee Lee Jeju National University
Rasika M. Harshey
Rasika M. Harshey The University of Texas at Austin
Yasuji Oshima
Yasuji Oshima Osaka University
Hiroyuki Araki
Hiroyuki Araki National Institute of Genetics
James R. Broach
James R. Broach Pennsylvania State University
Thomas Dandekar
Thomas Dandekar University of Würzburg
David B. Teplow
David B. Teplow University of California, Los Angeles
Shyam Biswal
Shyam Biswal Johns Hopkins University
Thomas D. Tullius
Thomas D. Tullius Boston University

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