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Molecular Biology

D-Index
49
Citations
10767
World Ranking
2616
National Ranking
202

Research.com Recognitions

  • Member of the European Molecular Biology Organization (EMBO)
  • Member of the European Molecular Biology Organization (EMBO)

Overview

Karim Labib is affiliated with the University of Dundee in the United Kingdom. Their research spans multiple areas within biochemistry, genetics, and molecular biology, with a primary focus on molecular biology and medicine.

The scientist's recent work includes the following publications:

  • "A conserved mechanism for regulating replisome disassembly in eukaryotes" (2021), published in Nature
  • "CMG helicase disassembly is controlled by replication fork DNA, replisome components and a ubiquitin threshold" (2020), published in eLife
  • "Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp15 endoribonuclease" (2021), published in Biochemical Journal
  • "Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp3 papain-like protease" (2021), published in Biochemical Journal
  • "Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of Nsp5 main protease" (2021), published in Biochemical Journal

The main fields of study for Karim Labib are:

  • Biochemistry, Genetics and Molecular Biology
  • Medicine

Subfields of study include:

  • Molecular Biology
  • Infectious Diseases
  • Cell Biology
  • Immunology
  • Epidemiology

Key research topics investigated are:

  • DNA Repair Mechanisms
  • Ubiquitin and proteasome pathways
  • SARS-CoV-2 and COVID-19 Research
  • Microtubule and mitosis dynamics
  • Interferon and immune responses
  • Autophagy in Disease and Therapy
  • Viral gastroenteritis research and epidemiology

Karim Labib frequently publishes in the following venues:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Biochemical Journal
  • The EMBO Journal
  • Nature
  • eLife

The scientist collaborates regularly with several coauthors, including:

  • Ryo Fujisawa
  • Tom Deegan
  • Berta Canal
  • Mary Wu
  • Rachel Ulferts

Karim Labib has been recognized as a Member of the European Molecular Biology Organization (EMBO).

Best Publications

  • GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks

    Agnieszka Gambus;Richard C. Jones;Alberto Sanchez-Diaz;Masato Kanemaki

  • Uninterrupted MCM2-7 Function Required for DNA Replication Fork Progression

    Karim Labib;José Antonio Tercero;John F. X. Diffley

  • Chromosome Duplication in Saccharomyces cerevisiae.

    Stephen P Bell;Karim Labib

  • How do Cdc7 and cyclin-dependent kinases trigger the initiation of chromosome replication in eukaryotic cells?

    Karim Labib

  • MCM proteins: evolution, properties, and role in DNA replication.

    Stephen E. Kearsey;Karim Labib

  • MINDY-1 Is a Member of an Evolutionarily Conserved and Structurally Distinct New Family of Deubiquitinating Enzymes.

    Syed Arif Abdul Rehman;Yosua Adi Kristariyanto;Soo-Youn Choi;Pedro Junior Nkosi

  • Molecular anatomy and regulation of a stable replisome at a paused eukaryotic DNA replication fork

    Arturo Calzada;Ben Hodgson;Masato Kanemaki;Avelino Bueno

  • A key role for Ctf4 in coupling the MCM2-7 helicase to DNA polymerase α within the eukaryotic replisome

    Agnieszka Gambus;Frederick van Deursen;Dimitrios Polychronopoulos;Magdalena Foltman

  • Functional proteomic identification of DNA replication proteins by induced proteolysis in vivo

    Masato Kanemaki;Alberto Sanchez-Diaz;Agnieszka Gambus;Karim Labib

  • G1-phase and B-type cyclins exclude the DNA-replication factor Mcm4 from the nucleus.

    Karim Labib;John F.X. Diffley;Stephen E. Kearsey

  • Cdc48 and a ubiquitin ligase drive disassembly of the CMG helicase at the end of DNA replication

    Marija Maric;Marija Maric;Timurs Maculins;Giacomo De Piccoli;Karim Labib

  • DNA synthesis at individual replication forks requires the essential initiation factor Cdc45p

    José Antonio Tercero;Karim Labib;John F.X. Diffley

  • A Ctf4 trimer couples the CMG helicase to DNA polymerase α in the eukaryotic replisome

    Aline C. Simon;Jin C. Zhou;Rajika L. Perera;Rajika L. Perera;Frederick van Deursen

  • Replication fork barriers: pausing for a break or stalling for time?

    Karim Labib;Ben Hodgson

  • Is the MCM2-7 complex the eukaryotic DNA replication fork helicase?

    Karim Labib;John F.X Diffley

  • Mrc1 and Tof1 Regulate DNA Replication Forks in Different Ways during Normal S Phase

    Ben Hodgson;Arturo Calzada;Karim Labib

  • Eukaryotic Replisome Components Cooperate to Process Histones During Chromosome Replication

    Magdalena Foltman;Cecile Evrin;Giacomo De Piccoli;Richard C. Jones

  • MCM2-7 proteins are essential components of prereplicative complexes that accumulate cooperatively in the nucleus during G1-phase and are required to establish, but not maintain, the S-phase checkpoint.

    Karim Labib;Stephen E. Kearsey;John F.X. Diffley

  • Mcm10 associates with the loaded DNA helicase at replication origins and defines a novel step in its activation

    Frederick van Deursen;Sugopa Sengupta;Giacomo De Piccoli;Alberto Sanchez-Diaz

  • Replisome Stability at Defective DNA Replication Forks Is Independent of S Phase Checkpoint Kinases

    Giacomo De Piccoli;Yuki Katou;Takehiko Itoh;Ryuichiro Nakato

Frequent Co-Authors

John F. X. Diffley
John F. X. Diffley The Francis Crick Institute
Anton Gartner
Anton Gartner University of Dundee
Michael Howell
Michael Howell The Francis Crick Institute
Masato T. Kanemaki
Masato T. Kanemaki National Institute of Genetics
Johannes C. Walter
Johannes C. Walter Harvard University
Niels Mailand
Niels Mailand University of Copenhagen
Katsuhiko Shirahige
Katsuhiko Shirahige University of Tokyo
Ian D. Hickson
Ian D. Hickson University of Copenhagen
Hui Zhou
Hui Zhou Sun Yat-sen University
Kay Hofmann
Kay Hofmann University of Cologne

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