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Biology and Biochemistry

D-Index
62
Citations
14417
World Ranking
10747
National Ranking
823

Overview

Michael Howell is affiliated with The Francis Crick Institute in the United Kingdom. Their research primarily spans the fields of Medicine and Biochemistry, Genetics, and Molecular Biology, with a significant focus on infectious diseases and molecular biology.

Their subfields of study include:

  • Infectious Diseases
  • Molecular Biology
  • Oncology
  • Immunology
  • Genetics

Main topics of Michael Howell's research work comprise:

  • SARS-CoV-2 and COVID-19 Research
  • COVID-19 Clinical Research Studies
  • SARS-CoV-2 detection and testing
  • COVID-19 and healthcare impacts
  • Viral gastroenteritis research and epidemiology
  • Viral Infections and Outbreaks Research
  • Epigenetics and DNA Methylation

Michael Howell has contributed to several recent papers, including:

  • Neutralising antibody activity against SARS-CoV-2 VOCs B.1.617.2 and B.1.351 by BNT162b2 vaccination, 2021, The Lancet
  • Adaptive immunity and neutralizing antibodies against SARS-CoV-2 variants of concern following vaccination in patients with cancer: the CAPTURE study, 2021, Nature Cancer
  • AZD1222-induced neutralising antibody activity against SARS-CoV-2 Delta VOC, 2021, The Lancet
  • Induction of APOBEC3 Exacerbates DNA Replication Stress and Chromosomal Instability in Early Breast and Lung Cancer Evolution, 2021, Cancer Discovery
  • Microbial communities form rich extracellular metabolomes that foster metabolic interactions and promote drug tolerance, 2022, Nature Microbiology

Their frequent co-authors include:

  • Mary Wu
  • Rupert Beale
  • Charles Swanton
  • George Kassiotis
  • Sonia Gandhi

Michael Howell has published regularly in a variety of scientific venues. Their most frequent publication venues are:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Biochemical Journal
  • The Lancet
  • Nature Communications
  • Journal of Investigative Dermatology

Best Publications

  • Replication stress links structural and numerical cancer chromosomal instability

    Rebecca A. Burrell;Sarah E. McClelland;David Endesfelder;Petra Groth

  • Acetyl-CoA Synthetase 2 Promotes Acetate Utilization and Maintains Cancer Cell Growth under Metabolic Stress

    Zachary T. Schug;Barrie Peck;Dylan T. Jones;Qifeng Zhang

  • Replication stress links structural and numerical cancer chromosomal instability (vol 494, pg 492, 2013)

    RA Burrell;SE McClelland;D Endesfelder;P Groth

  • Chromosomal Instability Confers Intrinsic Multidrug Resistance

    Alvin J. X. Lee;David Endesfelder;Andrew J. Rowan;Axel Walther

  • The novel mechanism of initiation of picornavirus RNA translation.

    Richard J. Jackson;Michael T. Howell;Ann Kaminski

  • Neutralising antibody activity against SARS-CoV-2 VOCs B.1.617.2 and B.1.351 by BNT162b2 vaccination.

    Emma C Wall;Emma C Wall;Emma C Wall;Mary Wu;Ruth Harvey;Gavin Kelly

  • Interaction between the origin recognition complex and the replication licensing system in Xenopus.

    Alison Rowles;James P.J Chong;Lamorna Brown;Mike Howell

  • Chromosomal instability determines taxane response

    Charles Swanton;Barbara Nicke;Marion Schuett;Aron C. Eklund

  • T cell repertoire following autologous stem cell transplantation for multiple sclerosis.

    Paolo A. Muraro;Harlan Robins;Sachin Malhotra;Michael Howell

  • Randomized trial of intermittent intraputamenal glial cell line-derived neurotrophic factor in Parkinson’s disease

    Alan Whone;Alan Whone;Matthias Luz;Mihaela Boca;Max Woolley

  • The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma.

    Heike Miess;Beatrice Dankworth;Arvin M. Gouw;Mathias Rosenfeldt

  • Initiation of encephalomyocarditis virus RNA translation: the authentic initiation site is not selected by a scanning mechanism.

    A Kaminski;M T Howell;R J Jackson

  • Inhibition of fatty acid desaturation is detrimental to cancer cell survival in metabolically compromised environments.

    Barrie Peck;Barrie Peck;Zachary T. Schug;Qifeng Zhang;Beatrice Dankworth

  • Identification of a developmental timer regulating the stability of embryonic cyclin A and a new somatic A-type cyclin at gastrulation.

    John A. Howe;Mike Howell;Tim Hunt;John W. Newport

  • Functional Metabolic Screen Identifies 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 4 as an Important Regulator of Prostate Cancer Cell Survival

    Susana Ros;Claudio R. Santos;Sofia Moco;Franziska Baenke

  • Arkadia Activates Smad3/Smad4-Dependent Transcription by Triggering Signal-Induced SnoN Degradation

    Laurence Levy;Michael Howell;Debipriya Das;Sean Harkin

  • Nuclear import impairment causes cytoplasmic trans-activation response DNA-binding protein accumulation and is associated with frontotemporal lobar degeneration

    Nishimura Al;Zupunski;Troakes C;Kathe C

  • Smads orchestrate specific histone modifications and chromatin remodeling to activate transcription

    Sarah Ross;Edwin Cheung;Edwin Cheung;Thodoris G Petrakis;Michael Howell

  • Both cyclin A and cyclin E have S-phase promoting (SPF) activity in Xenopus egg extracts.

    Ulrich P. Strausfeld;Mike Howell;Patrick Descombes;Stephane Chevalier

  • Determination of synthetic lethal interactions in KRAS oncogene-dependent cancer cells reveals novel therapeutic targeting strategies

    Michael Steckel;Miriam Molina-Arcas;Britta Weigelt;Michaela Marani

Frequent Co-Authors

Charles Swanton
Charles Swanton The Francis Crick Institute
George Kassiotis
George Kassiotis The Francis Crick Institute
Caroline S. Hill
Caroline S. Hill The Francis Crick Institute
Julian Downward
Julian Downward The Francis Crick Institute
Samra Turajlic
Samra Turajlic Royal Marsden NHS Foundation Trust
Peter J. Parker
Peter J. Parker The Francis Crick Institute
Mike Hubank
Mike Hubank Royal Marsden NHS Foundation Trust
Robert J. Wilkinson
Robert J. Wilkinson The Francis Crick Institute
John F. X. Diffley
John F. X. Diffley The Francis Crick Institute
Robert L. Goldstone
Robert L. Goldstone Indiana University

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