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Biology and Biochemistry

D-Index
58
Citations
24919
World Ranking
12891
National Ranking
922

Overview

Almut Schulze is affiliated with the German Cancer Research Center in Germany and has an extensive publication record that spans multiple aspects of cancer biology, lipid metabolism, and molecular signaling in health and disease contexts.

The researcher's recent publications include:

  • Hydropersulfides inhibit lipid peroxidation and ferroptosis by scavenging radicals (2022, Nature Chemical Biology)
  • Ferroptosis in health and disease (2024, Redox Biology)
  • Lipids as mediators of cancer progression and metastasis (2024, Nature Cancer)
  • MiR-205-driven downregulation of cholesterol biosynthesis through SQLE-inhibition identifies therapeutic vulnerability in aggressive prostate cancer (2021, Nature Communications)
  • mTOR Signaling and SREBP Activity Increase FADS2 Expression and Can Activate Sapienate Biosynthesis (2020, Cell Reports)

Frequent coauthors in Schulze's work include:

  • Lisa Schlicker
  • Werner Schmitz
  • Marteinn T. Snaebjornsson
  • Felix C. E. Vogel
  • Martin Eilers

Schulze's studies have often been published in notable venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Cancer
  • Nature
  • Nature Communications
  • Cell Reports

The main fields of study covered by Schulze are Biochemistry, Genetics and Molecular Biology, with significant interdisciplinary work in Medicine.

Subfields include:

  • Molecular Biology
  • Cancer Research
  • Pulmonary and Respiratory Medicine
  • Immunology
  • Surgery

Core research topics focus on:

  • Cancer, Lipids, and Metabolism
  • Cancer, Hypoxia, and Metabolism
  • Ferroptosis and cancer prognosis
  • RNA modifications and cancer
  • Lipid metabolism and biosynthesis
  • Metabolomics and Mass Spectrometry Studies
  • Cholesterol and Lipid Metabolism

Through these research themes, Schulze investigates molecular mechanisms underlying cancer progression, the role of lipid pathways and ferroptosis in tumor biology, and potential therapeutic vulnerabilities in cancer metabolism.

Best Publications

  • FSP1 is a glutathione-independent ferroptosis suppressor

    Sebastian Doll;Florencio Porto Freitas;Ron Shah;Maceler Aldrovandi

  • Cellular fatty acid metabolism and cancer

    Erin Currie;Almut Schulze;Rudolf Zechner;Tobias C. Walther

  • SREBP Activity Is Regulated by mTORC1 and Contributes to Akt-Dependent Cell Growth

    Thomas Porstmann;Claudio R. Santos;Beatrice Griffiths;Megan Cully

  • Lipid metabolism in cancer

    Claudio R. Santos;Almut Schulze

  • The multifaceted roles of fatty acid synthesis in cancer

    Florian Röhrig;Almut Schulze

  • How cancer metabolism is tuned for proliferation and vulnerable to disruption

    Almut Schulze;Adrian L. Harris

  • Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour development

    Franziska Baenke;Barrie Peck;Heike Miess;Almut Schulze

  • Navigating gene expression using microarrays — a technology review

    Almut Schulze;Julian Downward

  • Acetyl-CoA Synthetase 2 Promotes Acetate Utilization and Maintains Cancer Cell Growth under Metabolic Stress

    Zachary T. Schug;Barrie Peck;Dylan T. Jones;Qifeng Zhang

  • Greasing the Wheels of the Cancer Machine: The Role of Lipid Metabolism in Cancer.

    Marteinn Thor Snaebjornsson;Sudha Janaki-Raman;Almut Schulze

  • Fatty Acid Uptake and Lipid Storage Induced by HIF-1α Contribute to Cell Growth and Survival after Hypoxia-Reoxygenation

    Karim Bensaad;Elena Favaro;Caroline A. Lewis;Barrie Peck

  • PKB/Akt induces transcription of enzymes involved in cholesterol and fatty acid biosynthesis via activation of SREBP.

    Thomas Porstmann;Beatrice Griffiths;Yuen-Li Chung;Oona Delpuech

  • Cell cycle regulation of the cyclin A gene promoter is mediated by a variant E2F site.

    Almut Schulze;Karin Zerfass;Dimitry Spitkovsky;Sandrine Middendorp

  • Raf induces TGFbeta production while blocking its apoptotic but not invasive responses: a mechanism leading to increased malignancy in epithelial cells.

    Kerstin Lehmann;Elzbieta Janda;Christophe E. Pierreux;Marjatta Rytömaa

  • Analysis of the transcriptional program induced by Raf in epithelial cells

    Almut Schulze;Kerstin Lehmann;Harold B. Jefferies;Martin McMahon

  • FOXO3a regulates reactive oxygen metabolism by inhibiting mitochondrial gene expression

    Emma C. Ferber;Barrie Peck;Oona Delpuech;Oona Delpuech;Graham P. Bell

  • Sequential activation of cyclin E and cyclin A gene expression by human papillomavirus type 16 E7 through sequences necessary for transformation.

    K Zerfass;A Schulze;D Spitkovsky;V Friedman

  • Balancing glycolytic flux: the role of 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatases in cancer metabolism.

    Susana Ros;Almut Schulze

  • The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma.

    Heike Miess;Beatrice Dankworth;Arvin M. Gouw;Mathias Rosenfeldt

  • Sterol regulatory element binding protein-dependent regulation of lipid synthesis supports cell survival and tumor growth

    Beatrice Griffiths;Caroline A Lewis;Caroline A Lewis;Karim Bensaad;Susana Ros

Frequent Co-Authors

Julian Downward
Julian Downward The Francis Crick Institute
adrian l harris
adrian l harris University of Oxford
Pidder Jansen-Dürr
Pidder Jansen-Dürr University of Innsbruck
Michael J. O. Wakelam
Michael J. O. Wakelam Babraham Institute
Michael Howell
Michael Howell The Francis Crick Institute
Fredrik Karpe
Fredrik Karpe University of Oxford
Martin Eilers
Martin Eilers University of Würzburg
Eyal Gottlieb
Eyal Gottlieb Technion – Israel Institute of Technology
Nicola Zamboni
Nicola Zamboni ETH Zurich
Thomas Rudel
Thomas Rudel Helmholtz Institute for RNA-based Infection Research

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