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Biology and Biochemistry

D-Index
87
Citations
27564
World Ranking
2828
National Ranking
207

Overview

Barbara Seliger is affiliated with Martin Luther University Halle-Wittenberg in Germany. Their research spans several scientific fields, primarily focusing on medicine, immunology and microbiology, and biochemistry, genetics, and molecular biology. Seliger's work reflects a strong interdisciplinary approach, contributing to both basic and applied biomedical sciences.

Their publication record includes significant contributions to subfields such as immunology, oncology, molecular biology, cancer research, and pulmonary and respiratory medicine. This broad set of subfields underscores a comprehensive engagement with both fundamental immune system mechanisms and their implications in cancer and other diseases.

Seliger's main research topics include cancer immunotherapy and biomarkers, immune cell function and interaction, immunotherapy and immune responses, cancer genomics and diagnostics, CAR-T cell therapy research, microRNA in disease regulation, and aspects of the reproductive system and pregnancy.

Key recent publications illustrate the diversity and depth of Seliger's research interests:

  • What turns CREB on? And off? And why does it matter? (2020, Cellular and Molecular Life Sciences)
  • Immunoprophylactic and immunotherapeutic control of hormone receptor-positive breast cancer (2020, Nature Communications)
  • Nectin4 is a novel TIGIT ligand which combines checkpoint inhibition and tumor specificity (2020, Journal for ImmunoTherapy of Cancer)
  • "UniCAR"-modified off-the-shelf NK-92 cells for targeting of GD2-expressing tumour cells (2020, Scientific Reports)
  • Epstein-Barr Virus-Associated Malignancies and Immune Escape: The Role of the Tumor Microenvironment and Tumor Cell Evasion Strategies (2021, Cancers)

Throughout their career, Seliger has collaborated extensively with other researchers. Frequent coauthors include Claudia Wickenhauser, Chiara Massa, Marcus Bauer, Christoforos Vaxevanis, and Karthikeyan Subbarayan. These collaborations have contributed to a diversified research portfolio and enhanced interdisciplinary linkages.

Seliger has published predominantly in a set of recurrent scientific journals and venues, highlighting their ongoing engagement with peer communities in immunology and oncology. Frequent publication outlets include Frontiers in Immunology, Cancers, OncoImmunology, Preprints.org, and Journal for ImmunoTherapy of Cancer.

Best Publications

  • LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells.

    Almut Brand;Katrin Singer;Gudrun E. Koehl;Marlene Kolitzus

  • Antigen-processing machinery breakdown and tumor growth.

    Barbara Seliger;Markus J Maeurer;Soldano Ferrone

  • Hydrogen peroxide – production, fate and role in redox signaling of tumor cells

    Claudia Lennicke;Jette Rahn;Rudolf Lichtenfels;Ludger A. Wessjohann

  • Cancer immunotherapy: Opportunities and challenges in the rapidly evolving clinical landscape.

    Leisha A. Emens;Paolo A. Ascierto;Phillip K. Darcy;Sandra Demaria

  • Classification of current anticancer immunotherapies

    Lorenzo Galluzzi;Erika Vacchelli;José Manuel Bravo-San Pedro;Aitziber Buqué

  • Two tyrosinase nonapeptides recognized on HLA‐A2 melanomas by autologous cytolytic T lymphocytes

    T Wölfel;A Van Pel;V Brichard;J Schneider

  • Tumor-specific T cell activation by recombinant immunoreceptors: CD3 zeta signaling and CD28 costimulation are simultaneously required for efficient IL-2 secretion and can be integrated into one combined CD28/CD3 zeta signaling receptor molecule.

    Andreas Hombach;Anja Wieczarkowiecz;Thomas Marquardt;Claudia Heuser

  • Defects in the Human Leukocyte Antigen Class I Antigen Processing Machinery in Head and Neck Squamous Cell Carcinoma: Association with Clinical Outcome

    Markus Meissner;Torsten E. Reichert;Martin Kunkel;William Gooding

  • HLA class I antigen abnormalities and immune escape by malignant cells.

    Barbara Seliger;Teresa Cabrera;Federico Garrido;Soldano Ferrone

  • TAP off — tumors on

    Barbara Seliger;Barbara Seliger;Markus J. Maeurer;Markus J. Maeurer;Soldano Ferrone;Soldano Ferrone

  • Tumors as elusive targets of T-cell-based active immunotherapy.

    Francesco M Marincola;Ena Wang;Meenhard Herlyn;Barbara Seliger

  • Inhibition of Tumor-Derived Prostaglandin-E2 Blocks the Induction of Myeloid-Derived Suppressor Cells and Recovers Natural Killer Cell Activity

    Yumeng Mao;Dhifaf Sarhan;André Steven;Barbara Seliger

  • Small interfering RNA (siRNA) inhibits the expression of the Her2/neu gene, upregulates HLA class I and induces apoptosis of Her2/neu positive tumor cell lines

    Aniruddha Choudhury;Jehad Charo;Sunil K. Parapuram;Richard C. Hunt

  • Characterization of the major histocompatibility complex class I deficiencies in B16 melanoma cells.

    Barbara Seliger;Ursula Wollscheid;Frank Momburg;Thomas Blankenstein

  • Immune escape of melanoma: first evidence of structural alterations in two distinct components of the MHC class I antigen processing pathway.

    Barbara Seliger;Ulrike Ritz;Rupert Abele;Michaela Bock

  • NKp46 Receptor-Mediated Interferon-γ Production by Natural Killer Cells Increases Fibronectin 1 to Alter Tumor Architecture and Control Metastasis

    Ariella Glasner;Assi Levi;Jonatan Enk;Batya Isaacson

  • Immune signature of tumor infiltrating immune cells in renal cancer

    Katharina Geissler;Paolo Fornara;Christine Lautenschläger;Hans-Jürgen Holzhausen

  • 5-aza-2'-deoxycytidine-induced expression of functional cancer testis antigens in human renal cell carcinoma: immunotherapeutic implications.

    Sandra Coral;Luca Sigalotti;Maresa Altomonte;Arne Engelsberg

  • Strategies of Tumor Immune Evasion

    Barbara Seliger

  • Defining the critical hurdles in cancer immunotherapy

    Bernard A. Fox;Bernard A. Fox;Dolores J. Schendel;Lisa H. Butterfield;Steinar Aamdal

Frequent Co-Authors

Soldano Ferrone
Soldano Ferrone Harvard University
Alexander Knuth
Alexander Knuth University of Zurich
Robert Tampé
Robert Tampé Goethe University Frankfurt
Markus Maeurer
Markus Maeurer Champalimaud Foundation
Frank Momburg
Frank Momburg German Cancer Research Center
Hinrich Abken
Hinrich Abken University of Regensburg
Christoph Huber
Christoph Huber BioNTech (Germany)
Thomas Blankenstein
Thomas Blankenstein Max Delbrück Center for Molecular Medicine
Rolf Kiessling
Rolf Kiessling Karolinska Institute
Friedrich Lottspeich
Friedrich Lottspeich Max Planck Society

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