Hinrich Abken

Overview

Best Publications

• TRUCKs: the fourth generation of CARs.

  Markus Chmielewski;Hinrich Abken

  797
  Citations

• IL-12 release by engineered T cells expressing chimeric antigen receptors can effectively Muster an antigen-independent macrophage response on tumor cells that have shut down tumor antigen expression.

  Markus Chmielewski;Caroline Kopecky;Andreas A. Hombach;Hinrich Abken

  681
  Citations

• CAR T Cells Releasing IL-18 Convert to T-Bethigh FoxO1low Effectors that Exhibit Augmented Activity against Advanced Solid Tumors

  Markus Chmielewski;Hinrich Abken

  460
  Citations

• Of CARs and TRUCKs: chimeric antigen receptor (CAR) T cells engineered with an inducible cytokine to modulate the tumor stroma.

  Markus Chmielewski;Andreas A. Hombach;Hinrich Abken

  438
  Citations

• Tumor-specific T cell activation by recombinant immunoreceptors: CD3 zeta signaling and CD28 costimulation are simultaneously required for efficient IL-2 secretion and can be integrated into one combined CD28/CD3 zeta signaling receptor molecule.

  Andreas Hombach;Anja Wieczarkowiecz;Thomas Marquardt;Claudia Heuser

  434
  Citations

• T Cell Activation by Antibody-Like Immunoreceptors: Increase in Affinity of the Single-Chain Fragment Domain above Threshold Does Not Increase T Cell Activation against Antigen-Positive Target Cells but Decreases Selectivity

  Markus Chmielewski;Andreas Hombach;Claudia Heuser;Gregory P. Adams

  359
  Citations

• Adoptive immunotherapy with genetically engineered T cells: modification of the IgG1 Fc 'spacer' domain in the extracellular moiety of chimeric antigen receptors avoids 'off-target' activation and unintended initiation of an innate immune response.

  A Hombach;A A Hombach;H Abken

  297
  Citations

• OX40 costimulation by a chimeric antigen receptor abrogates CD28 and IL-2 induced IL-10 secretion by redirected CD4(+) T cells.

  Andreas A. Hombach;Johannes Heiders;Marcel Foppe;Markus Chmielewski

  287
  Citations

• Epstein Barr virus–specific cytotoxic T lymphocytes expressing the anti-CD30ζ artificial chimeric T-cell receptor for immunotherapy of Hodgkin disease

  Barbara Savoldo;Cliona M. Rooney;Cliona M. Rooney;Antonio Di Stasi;Hinrich Abken

  286
  Citations

• T Cells Expressing a Chimeric Antigen Receptor That Binds Hepatitis B Virus Envelope Proteins Control Virus Replication in Mice

  Karin Krebs;Nina Böttinger;Li–Rung Huang;Markus Chmielewski

  252
  Citations

• Engineering antigen-specific primary human NK cells against HER-2 positive carcinomas

  Anna Kruschinski;Andreas Moosmann;Isabel Poschke;Håkan Norell

  251
  Citations

• CAR-T cells and solid tumors: tuning T cells to challenge an inveterate foe.

  David E. Gilham;Reno Debets;Martin Pule;Robert E. Hawkins

  248
  Citations

• Coexpressed Catalase Protects Chimeric Antigen Receptor–Redirected T Cells as well as Bystander Cells from Oxidative Stress–Induced Loss of Antitumor Activity

  Maarten A. Ligtenberg;Dimitrios Mougiakakos;Madhura Mukhopadhyay;Kristina Witt

  216
  Citations

• The Analysis of Tyrosinase-Specific mRNA in Blood Samples of Melanoma Patients by RT-PCR Is Not a Useful Test for Metastic Tumor Progression

  Uwe Reinhold;Hans-Christian Lüdtke-Handjery;Hans-Christian Lüdtke-Handjery;Sylvia Schnautz;Hans-Wilhelm Kreysel

  210
  Citations

• Antigen-Specific T-Cell Activation Independently of the MHC: Chimeric Antigen Receptor-Redirected T Cells.

  Markus Chmielewski;Andreas A. Hombach;Hinrich Abken

  208
  Citations

• TRUCKS, the fourth‐generation CAR T cells: Current developments and clinical translation

  Unknown

  206
  Citations

• Costimulation by chimeric antigen receptors revisited the T cell antitumor response benefits from combined CD28-OX40 signalling.

  Andreas A. Hombach;Hinrich Abken

  201
  Citations

• T cells that target carcinoembryonic antigen eradicate orthotopic pancreatic carcinomas without inducing autoimmune colitis in mice.

  Markus Chmielewski;Olga Hahn;Gunter Rappl;Michael Nowak

  190
  Citations

• T Cells Redirected Against Hepatitis B Virus Surface Proteins Eliminate Infected Hepatocytes

  Felix Bohne;Markus Chmielewski;Gregor Ebert;Katja Wiegmann

  181
  Citations

• T-cell activation by recombinant receptors: CD28 costimulation is required for interleukin 2 secretion and receptor-mediated T-cell proliferation but does not affect receptor-mediated target cell lysis.

  Andreas Hombach;Dagmar Sent;Claudia Schneider;Claudia Heuser

  169
  Citations

• Eradication of melanomas by targeted elimination of a minor subset of tumor cells

  Patrick Schmidt;Caroline Kopecky;Andreas Hombach;Paola Zigrino

  163
  Citations