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Genetics

D-Index
56
Citations
11487
World Ranking
3504
National Ranking
1518

Overview

Bik Kwoon Tye is affiliated with Cornell University in the United States and conducts research primarily within the field of Biochemistry, Genetics, and Molecular Biology. Their work spans a number of related subfields, including Molecular Biology, Genetics, and Cell Biology. The scientist's research output comprises 21 publications within this broader field and delves into more focused topics such as DNA Repair Mechanisms, Genomics and Chromatin Dynamics, and Bacterial Genetics and Biotechnology.

Their recent research contributions include the following papers:

  • The human pre-replication complex is an open complex, 2023, Cell
  • Humanizing the yeast origin recognition complex, 2021, Nature Communications
  • Structural Insight into the MCM double hexamer activation by Dbf4-Cdc7 kinase, 2022, Nature Communications
  • The Origin Recognition Complex: From Origin Selection to Replication Licensing in Yeast and Humans, 2023, Biology
  • Four decades of Eukaryotic DNA replication: From yeast genetics to high-resolution cryo-EM structures of the replisome, 2024, Proceedings of the National Academy of Sciences

These publications reflect a focus on the molecular mechanisms underlying DNA replication and origin recognition complex functionality, with research appearing in journals such as Nature Communications, Cell, Biology, and the Proceedings of the National Academy of Sciences.

Frequent coauthors who collaborate with Bik Kwoon Tye include:

  • Yuanliang Zhai
  • Wai Hei Lam
  • Shangyu Dang
  • Ningning Li
  • Ning Gao

The scientist's work is regularly published in venues including:

  • Nature Communications
  • Proceedings of the National Academy of Sciences
  • Cell
  • Biology
  • Biophysical Journal

Bik Kwoon Tye's research topics cover a diverse spectrum with a significant emphasis on:

  • DNA Repair Mechanisms
  • Genomics and Chromatin Dynamics
  • Bacterial Genetics and Biotechnology
  • RNA and protein synthesis mechanisms
  • Microtubule and mitosis dynamics
  • Fungal and yeast genetics research
  • RNA modifications and cancer

Best Publications

  • MCM Proteins in DNA Replication

    Bik Kwoon Tye

  • Mutants of S. cerevisiae defective in the maintenance of minichromosomes.

    Gregory T. Maine;Pratima Sinha;Bik Kwoon Tye

  • Initiating DNA synthesis: from recruiting to activating the MCM complex.

    Ming Lei;Bik Kwoon Tye

  • Mcm2 is a target of regulation by Cdc7–Dbf4 during the initiation of DNA synthesis

    Ming Lei;Yasuo Kawasaki;Michael R. Young;Makoto Kihara

  • Organization of DNA sequences and replication origins at yeast telomeres.

    Clarence S.M. Chan;Bik Kwoon Tye

  • Mutagenesis by insertion of a drug-resistance element carrying an inverted repetition.

    Nancy Kleckner;Russell K. Chan;Bik Kwoon Tye;David Botstein

  • Transient accumulation of Okazaki fragments as a result of uracil incorporation into nascent DNA

    Bik-Kwoon Tye;Per-Olof Nyman;I. R. Lehman;Steven Hochhauser

  • Saccharomyces cerevisiae protein involved in plasmid maintenance is necessary for mating of MATα cells

    Steven Passmore;Gregory T. Maine;Randolph Elble;Chantal Christ

  • A viable allele of Mcm4 causes chromosome instability and mammary adenocarcinomas in mice

    Naoko Shima;Ana Alcaraz;Ivan Liachko;Tavanna R. Buske

  • Cell cycle-regulated nuclear localization of MCM2 and MCM3, which are required for the initiation of DNA synthesis at chromosomal replication origins in yeast.

    Hong Yan;Ankit Margaret Merchant;Bik Kwoon Tye

  • Autonomously replicating sequences in Saccharomyces cerevisiae

    Clarence S.M. Chan;Bik Kwoon Tye

  • A protein involved in minichromosome maintenance in yeast binds a transcriptional enhancer conserved in eukaryotes.

    Steven Passmore;Randolph Elble;Bik Kwoon Tye

  • Unusual DNA sequences associated with the ends of yeast chromosomes.

    Richard M. Walmsley;Clarence S.M. Chan;Bik Kwoon Tye;Thomas D. Petes

  • Mcm2 and Mcm3, two proteins important for ARS activity, are related in structure and function.

    Hong Yan;Susan Gibson;Susan Gibson;Bik Kwoon Tye

  • Mcm10 and the MCM2–7 complex interact to initiate DNA synthesis and to release replication factors from origins

    Lisa Homesley;Ming Lei;Ming Lei;Yasuo Kawasaki;Yasuo Kawasaki;Sara Lea Sawyer

  • Structure of the eukaryotic MCM complex at 3.8 A

    Ningning Li;Yuanliang Zhai;Yixiao Zhang;Wanqiu Li

  • Physical interactions among Mcm proteins and effects of Mcm dosage on DNA replication in Saccharomyces cerevisiae.

    Ming Lei;Yasuo Kawasaki;Bik Kwoon Tye

  • Non-random circular permutation of phage P22 DNA.

    Bik-Kwoon Tye;Joel A. Huberman;David Botstein

  • A lesion in the DNA replication initiation factor Mcm10 induces pausing of elongation forks through chromosomal replication origins in Saccharomyces cerevisiae.

    A M Merchant;Y Kawasaki;Y Chen;M Lei

  • Transient accumulation of Okazaki fragments as a result of uracil incorporation into nascent DNA (deoxyuridinetriphosphatase/dnaS gene/sof gene)

    Bik-Kwoon Tye;Per-Olof Nyman;I. R. Lehman

Frequent Co-Authors

David Botstein
David Botstein Princeton University
I. R. Lehman
I. R. Lehman Stanford University
Thomas D. Petes
Thomas D. Petes Duke University
Carol S. Newlon
Carol S. Newlon Rutgers, The State University of New Jersey
John C. Schimenti
John C. Schimenti Cornell University
Judith Berman
Judith Berman Tel Aviv University
Akio Sugino
Akio Sugino Osaka University
Ira Herskowitz
Ira Herskowitz University of California, San Francisco
Nancy Kleckner
Nancy Kleckner Harvard University
James E. Haber
James E. Haber Brandeis University

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