2026 David Botstein: Genetics Researcher – H-Index, Publications & Awards

Discipline name	D-Index	World Ranking	Current World Ranking	National Ranking	Current National Ranking	Publications	Citations
Best Scientists	190	411	381	276	251	525	299174
Genetics	189	35		23		494	305262

Research.com Recognitions

2025 - Research.com Best Scientists Award
2025 - Research.com Genetics in United States Leader Award
2024 - Research.com Genetics in United States Leader Award
2024 - Research.com Genetics and Molecular Biology in United States Leader Award
2023 - Research.com Genetics in United States Leader Award
2013 - Warren Alpert Foundation Prize For their seminal contributions to concepts and methods of creating a genetic map in the human, and of positional cloning, leading to the identification of thousands of human disease genes and ushering in the era of human genetics.
2013 - Breakthrough Prize in Life Sciences for linkage mapping of Mendelian disease in humans using DNA polymorphisms.
2010 - Albany Medical Center Prize in Medicine and Biomedical Research
2006 - Joseph Zubin Award, American Psychopathological Association
2003 - Gruber Prize in Genetics
1998 - Promega Biotechnology Research Award, American Society for Microbiology
1993 - Member of the National Academy of Medicine (NAM)
1989 - William Allan Award, the American Society of Human Genetics
1988 - Genetics Society of America Medal
1987 - Fellow of the American Association for the Advancement of Science (AAAS)
1985 - Fellow of the American Academy of Arts and Sciences
1981 - Member of the National Academy of Sciences

Overview

David Botstein is affiliated with Princeton University in the United States. Their research primarily spans the field of Biochemistry, Genetics and Molecular Biology, focusing extensively on Molecular Biology, Physiology, Aging, Plant Science, and Cell Biology. Their work often addresses core topics such as fungal and yeast genetics research, dietary effects on health, genetics, aging and longevity in model organisms, CRISPR and genetic engineering, genomics and phylogenetic studies, gut microbiota and health, and plant biochemistry and biosynthesis.

Recent papers authored or co-authored by David Botstein include:

Dietary restriction impacts health and lifespan of genetically diverse mice, 2024, Nature
A genome-scale yeast library with inducible expression of individual genes, 2021, Molecular Systems Biology
Global analysis of the yeast knockout phenome, 2023, Science Advances
Regulators of health and lifespan extension in genetically diverse mice on dietary restriction, 2023, bioRxiv (Cold Spring Harbor Laboratory)
Fully Phased Sequence of a Diploid Human Genome Determined de Novo from the DNA of a Single Individual, 2020, G3 Genes Genomes Genetics

Frequent co-authors collaborating with Botstein include Kevin M. Wright, Adam Freund, Rebecca Y. Wang, Andrea Di Francesco, and Andrew Deighan.

The venues where the scientist most frequently publishes are:

bioRxiv (Cold Spring Harbor Laboratory)
UNC Libraries
Nature
Molecular Systems Biology
Science Advances

David Botstein has received several awards over the course of their career, including:

Warren Alpert Foundation Prize, 2013, for seminal contributions to concepts and methods of creating a genetic map in the human, and of positional cloning, leading to identifying thousands of human disease genes and ushering in the era of human genetics
Breakthrough Prize in Life Sciences, 2013, for linkage mapping of Mendelian disease in humans using DNA polymorphisms
Albany Medical Center Prize in Medicine and Biomedical Research, 2010
Joseph Zubin Award, American Psychopathological Association, 2006
Gruber Prize in Genetics, 2003
Promega Biotechnology Research Award, American Society for Microbiology, 1998
Member of the National Academy of Medicine (NAM), 1993
William Allan Award, the American Society of Human Genetics, 1989
Genetics Society of America Medal, 1988
Fellow of the American Association for the Advancement of Science (AAAS), 1987
Fellow of the American Academy of Arts and Sciences, 1985
Member of the National Academy of Sciences, 1981

Best Publications

Gene Ontology: tool for the unification of biology

M Ashburner;C A Ball;J A Blake;D Botstein

48018
Citations
Cluster analysis and display of genome-wide expression patterns

Michael B. Eisen;Paul T. Spellman;Patrick O. Brown;David Botstein

20810
Citations
Molecular portraits of human breast tumours

Charles M. Perou;Therese Sørlie;Michael B. Eisen;Matt van de Rijn

20711
Citations
Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications

Therese Sørlie;Charles M. Perou;Robert Tibshirani;Turid Aas

14032
Citations
Construction of a genetic linkage map in man using restriction fragment length polymorphisms.

D Botstein;R L White;M Skolnick;R W Davis

13990
Citations
Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling

Ash A. Alizadeh;Michael B. Eisen;R. Eric Davis;Izidore S. Lossos

12762
Citations
Repeated observation of breast tumor subtypes in independent gene expression data sets

Therese Sørlie;Robert Tibshirani;Joel Parker;Trevor Hastie

7058
Citations
MAPPING MENDELIAN FACTORS UNDERLYING QUANTITATIVE TRAITS USING RFLP LINKAGE MAPS

E S Lander;D Botstein

7005
Citations
Comprehensive Identification of Cell Cycle–regulated Genes of the Yeast Saccharomyces cerevisiae by Microarray Hybridization

Paul T. Spellman;Gavin Sherlock;Gavin Sherlock;Michael Q. Zhang;Vishwanath R. Iyer

6548
Citations
Genomic expression programs in the response of yeast cells to environmental changes.

Audrey P. Gasch;Paul T. Spellman;Camilla M. Kao;Orna Carmel-Harel

6053
Citations
The Gene Ontology (GO) database and informatics resource.

Harris Ma;Clark J;Ireland A;Lomax J

5235
Citations
Missing value estimation methods for DNA microarrays.

Olga G. Troyanskaya;Michael N. Cantor;Gavin Sherlock;Patrick O. Brown

4965
Citations
Exploring the new world of the genome with DNA microarrays

Patrick O. Brown;David Botstein

3488
Citations
Advanced bacterial genetics

Ronald W. Davis;David Botstein;John R. Roth

3438
Citations
Advanced Bacterial Genetics: A Manual for Genetic Engineering

Ronald Wayne Davis;David Botstein;John Roger Roth

3026
Citations
Systematic variation in gene expression patterns in human cancer cell lines.

Douglas T. Ross;Uwe Scherf;Michael B. Eisen;Charles M. Perou

2730
Citations
The transcriptional program in the response of human fibroblasts to serum.

Vishwanath R. Iyer;Michael B. Eisen;Douglas T. Ross;Greg Schuler

2669
Citations
Singular value decomposition for genome-wide expression data processing and modeling

Orly Alter;Patrick O. Brown;David Botstein

2614
Citations
The Transcriptional Program of Sporulation in Budding Yeast

S. Chu;J. DeRisi;M. Eisen;J. Mulholland

2449
Citations
GO: :TermFinder---open source software for accessing Gene Ontology information and finding significantly enriched Gene Ontology terms associated with a list of genes

Elizabeth I. Boyle;Shuai Weng;Jeremy Gollub;Heng Jin

2277
Citations

Frequent Co-Authors

Patrick O. Brown Stanford University

Kara Dolinski Princeton University

Michael B. Eisen University of California, Berkeley

J. Michael Cherry Stanford University

Gavin Sherlock Stanford University

Ash A. Alizadeh Stanford University

Charles M. Perou University of North Carolina at Chapel Hill

Matt van de Rijn Stanford University

Ronald W. Davis Stanford University

Olga G. Troyanskaya Princeton University

External Links

Wikipedia of David Botstein Personal website of David Botstein

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