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Genetics

D-Index
73
Citations
21493
World Ranking
2033
National Ranking
931

Research.com Recognitions

  • 2020 - Member of the National Academy of Sciences
  • 2017 - Fellow of the American Academy of Arts and Sciences

Overview

Scott Keeney is affiliated with the Memorial Sloan Kettering Cancer Center in the United States. Their research contributions lie predominantly in the broad field of Biochemistry, Genetics, and Molecular Biology, with a particular focus on Molecular Biology, Plant Science, Genetics, Cancer Research, and Cell Biology.

Keeney's work addresses key topics within molecular and genetic research, including:

  • DNA Repair Mechanisms
  • Genomics and Chromatin Dynamics
  • CRISPR and Genetic Engineering
  • DNA and Nucleic Acid Chemistry
  • RNA Research and Splicing
  • Fungal and yeast genetics research
  • Chromosomal and Genetic Variations

Their recent publications highlight contributions to understanding protein complexes and meiotic processes. Some significant papers include:

  • Computed structures of core eukaryotic protein complexes, 2021, Science
  • The Configuration of RPA, RAD51, and DMC1 Binding in Meiosis Reveals the Nature of Critical Recombination Intermediates, 2020, Molecular Cell
  • Ensuring meiotic DNA break formation in the mouse pseudoautosomal region, 2020, Nature
  • DNA-driven condensation assembles the meiotic DNA break machinery, 2021, Nature
  • Structural and functional characterization of the Spo11 core complex, 2021, Nature Structural & Molecular Biology

Frequent publication venues for Keeney include bioRxiv (Cold Spring Harbor Laboratory), Nature, Genes & Development, Proceedings of the National Academy of Sciences, and Molecular Cell. These journals indicate a consistent presence in high-impact and specialized scientific outlets.

The scientist collaborates regularly with a close network of researchers, with frequent coauthors including Kaixian Liu, Stephen Pu, Shintaro Yamada, Devanshi Jain, and Soonjoung Kim.

Recognition for their contributions includes election as a Member of the National Academy of Sciences in 2020 and as a Fellow of the American Academy of Arts and Sciences in 2017.

Best Publications

  • Meiosis-specific DNA double-strand breaks are catalyzed by Spo11, a member of a widely conserved protein family.

    Scott Keeney;Craig N Giroux;Nancy Kleckner

  • Recombinational DNA double-strand breaks in mice precede synapsis

    Shantha K. Mahadevaiah;James M.A. Turner;Frédéric Baudat;Emmy P. Rogakou

  • Chromosome Synapsis Defects and Sexually Dimorphic Meiotic Progression in Mice Lacking Spo11

    Frédéric Baudat;Katia Manova;Julie Pui Yuen;Maria Jasin

  • Mechanism and control of meiotic recombination initiation.

    Scott Keeney

  • Endonucleolytic processing of covalent protein-linked DNA double-strand breaks

    Matthew J. Neale;Jing Pan;Scott Keeney;Scott Keeney

  • A hierarchical combination of factors shapes the genome-wide topography of yeast meiotic recombination initiation.

    Jing Pan;Mariko Sasaki;Mariko Sasaki;Ryan Kniewel;Ryan Kniewel;Hajime Murakami

  • Clarifying the mechanics of DNA strand exchange in meiotic recombination

    Matthew J. Neale;Scott Keeney

  • Computed structures of core eukaryotic protein complexes.

    Ian R. Humphreys;Jimin Pei;Minkyung Baek;Aditya Krishnakumar

  • Mechanism and Regulation of Meiotic Recombination Initiation

    Isabel Lam;Scott Keeney

  • Mouse HORMAD1 and HORMAD2, Two Conserved Meiotic Chromosomal Proteins, Are Depleted from Synapsed Chromosome Axes with the Help of TRIP13 AAA-ATPase

    Lukasz Wojtasz;Katrin Daniel;Ignasi Roig;Ewelina Bolcun-Filas

  • Spo11 and the Formation of DNA Double-Strand Breaks in Meiosis.

    Scott Keeney

  • Crossover Homeostasis in Yeast Meiosis

    Emmanuelle Martini;Robert L. Diaz;Neil Hunter;Scott Keeney

  • Where the crossovers are: recombination distributions in mammals.

    Liisa Kauppi;Liisa Kauppi;Alec J. Jeffreys;Scott Keeney

  • Comparative analysis of binding of human damaged DNA-binding protein (XPE) and Escherichia coli damage recognition protein (UvrA) to the major ultraviolet photoproducts: T[c,s]T, T[t,s]T, T[6-4]T, and T[Dewar]T.

    J T Reardon;A F Nichols;S Keeney;C A Smith

  • Initiation of meiotic recombination by formation of DNA double-strand breaks: mechanism and regulation

    S. Keeney;S. Keeney;M.J. Neale

  • Distinct DNA-damage-dependent and -independent responses drive the loss of oocytes in recombination-defective mouse mutants

    Monica Di Giacomo;Marco Barchi;Frédéric Baudat;Winfried Edelmann

  • The Landscape of Mouse Meiotic Double-Strand Break Formation, Processing, and Repair.

    Julian Lange;Shintaro Yamada;Sam E. Tischfield;Sam E. Tischfield;Jing Pan

  • Homeostatic control of recombination is implemented progressively in mouse meiosis

    Francesca Cole;Liisa Kauppi;Julian Lange;Ignasi Roig;Ignasi Roig

  • Characterization of a human DNA damage binding protein implicated in xeroderma pigmentosum E.

    S. Keeney;George J Chang;S. Linn

  • Progression of meiotic DNA replication is modulated by interchromosomal interaction proteins, negatively by Spo11p and positively by Rec8p

    Rita S. Cha;Beth M. Weiner;Scott Keeney;Job Dekker

Frequent Co-Authors

Maria Jasin
Maria Jasin Memorial Sloan Kettering Cancer Center
Dirk G. de Rooij
Dirk G. de Rooij Utrecht University
Stuart Linn
Stuart Linn University of California, Berkeley
Kathryn V. Anderson
Kathryn V. Anderson Memorial Sloan Kettering Cancer Center
Christopher E. Mason
Christopher E. Mason Cornell University
R. Daniel Camerini-Otero
R. Daniel Camerini-Otero National Institutes of Health
Nancy Kleckner
Nancy Kleckner Harvard University
James M. Berger
James M. Berger Johns Hopkins University
Winfried Edelmann
Winfried Edelmann Albert Einstein College of Medicine
Christopher D. Lima
Christopher D. Lima Memorial Sloan Kettering Cancer Center

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