World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
73
Citations
17815
World Ranking
5974
National Ranking
2820

Overview

Christopher D. Lima is affiliated with the Memorial Sloan Kettering Cancer Center in the United States. The primary field of research encompasses Biochemistry, Genetics, and Molecular Biology, with significant contributions in Molecular Biology, Cell Biology, Oncology, Cancer Research, and Aerospace Engineering. Their research spans multiple topics, particularly in RNA research and splicing, RNA modifications and cancer, RNA and protein synthesis mechanisms, ubiquitin and proteasome pathways, endoplasmic reticulum stress and disease, nuclear structure and function, and peptidase inhibition and analysis.

The scientist has authored numerous papers, with notable recent publications including:

  • "Structural basis for RNA surveillance by the human nuclear exosome targeting (NEXT) complex," 2022, published in Cell
  • "YTHDC2 control of gametogenesis requires helicase activity but not m6A binding," 2022, published in Genes & Development
  • "RNA helicases are hubs that orchestrate exosome-dependent 3'-5' decay," 2020, published in Current Opinion in Structural Biology
  • "Structural basis for transthiolation intermediates in the ubiquitin pathway," 2024, published in Nature
  • "SUMO enhances unfolding of SUMO-polyubiquitin-modified substrates by the Ufd1/Npl4/Cdc48 complex," 2022, published in Proceedings of the National Academy of Sciences

Frequent co-authors in the scientist's research include:

  • M Rhyan Puno
  • Tomasz Kochańczyk
  • Z.S. Hann
  • Michaelyn C. Lux
  • Avelyn Mae Delos Reyes

Most publications by Christopher D. Lima have appeared in the following venues:

  • Proceedings of the National Academy of Sciences
  • Cell
  • Nature
  • Genes & Development
  • Current Opinion in Structural Biology

Their work demonstrates involvement in both fundamental and applied aspects of molecular biology, especially examining processes related to RNA mechanisms and protein degradation pathways. Topics such as RNA splicing, RNA modifications in cancer, and the ubiquitin-proteasome system are recurrent themes, illustrating a focus on the molecular basis of cellular function and regulation.

Best Publications

  • The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition.

    Jaclyn R. Gareau;Christopher D. Lima

  • Ulp1-SUMO Crystal Structure and Genetic Analysis Reveal Conserved Interactions and a Regulatory Element Essential for Cell Growth in Yeast

    Elena Mossessova;Christopher D Lima

  • Structural basis for E2-mediated SUMO conjugation revealed by a complex between ubiquitin-conjugating enzyme Ubc9 and RanGAP1.

    Victor Bernier-Villamor;Deborah A. Sampson;Michael J. Matunis;Christopher D. Lima

  • Reconstitution, Activities, and Structure of the Eukaryotic RNA Exosome

    Quansheng Liu;Jaclyn C. Greimann;Christopher D. Lima

  • Insights into E3 ligase activity revealed by a SUMO–RanGAP1–Ubc9–Nup358 complex

    David Reverter;Christopher D. Lima

  • Metabolic enzymes of mycobacteria linked to antioxidant defense by a thioredoxin-like protein.

    R. Bryk;C. D. Lima;H. Erdjument-Bromage;P. Tempst;P. Tempst

  • Ubiquitin-like Protein Conjugation: Structures, Chemistry, and Mechanism

    Laurent Cappadocia;Christopher D. Lima;Christopher D. Lima

  • Three-dimensional structure of the 67K N-terminal fragment of E. coli DNA topoisomerase I

    Christopher D. Lima;James C. Wang;Alfonso Mondragón;Alfonso Mondragón

  • Structures of the SUMO E1 provide mechanistic insights into SUMO activation and E2 recruitment to E1

    Luisa Maria Lois;Christopher D Lima

  • The RNA Exosome Targets the AID Cytidine Deaminase to Both Strands of Transcribed Duplex DNA Substrates

    Uttiya Basu;Uttiya Basu;Fei-Long Meng;Celia Keim;Veronika Grinstein

  • Structure of an mRNA capping enzyme bound to the phosphorylated carboxy-terminal domain of RNA polymerase II.

    Carme Fabrega;Vincent Shen;Stewart Shuman;Christopher D. Lima

  • Targeting RNA for processing or destruction by the eukaryotic RNA exosome and its cofactors

    John C. Zinder;John C. Zinder;Christopher D. Lima;Christopher D. Lima

  • Structure-based analysis of catalysis and substrate definition in the HIT protein family.

    Christopher D. Lima;Michael G. Klein;Michael G. Klein;Wayne A. Hendrickson;Wayne A. Hendrickson

  • Small Ubiquitin-Like Modifier Modulates Abscisic Acid Signaling in Arabidopsis

    Luisa Maria Lois;Christopher D. Lima;Nam-Hai Chua

  • Specific and Covalent Targeting of Conjugating and Deconjugating Enzymes of Ubiquitin-Like Proteins

    Joris Hemelaar;Anna Borodovsky;Benedikt M. Kessler;David Reverter

  • A Basis for SUMO Protease Specificity Provided by Analysis of Human Senp2 and a Senp2-SUMO Complex

    David Reverter;Christopher D Lima

  • Active site remodelling accompanies thioester bond formation in the SUMO E1

    Shaun K. Olsen;Allan D. Capili;Xuequan Lu;Derek S. Tan

  • Structural and Biochemical Analysis of the Obg GTP Binding Protein

    John Buglino;Vincent Shen;Payam Hakimian;Christopher D. Lima

  • Structural genomics: A pipeline for providing structures for the biologist

    Mark R. Chance;Anne R. Bresnick;Stephen K. Burley;Stephen K. Burley;Jian Sheng Jiang

  • The polynucleotide ligase and RNA capping enzyme superfamily of covalent nucleotidyltransferases

    Stewart Shuman;Christopher D Lima

Frequent Co-Authors

Stewart Shuman
Stewart Shuman Memorial Sloan Kettering Cancer Center
Wayne A. Hendrickson
Wayne A. Hendrickson Columbia University
Carl Nathan
Carl Nathan Cornell University
Andrej Sali
Andrej Sali University of California, San Francisco
Beate Schwer
Beate Schwer Cornell University
Stephen K. Burley
Stephen K. Burley Rutgers, The State University of New Jersey
Christopher E. Mason
Christopher E. Mason Cornell University
Huib Ovaa
Huib Ovaa Leiden University Medical Center
Scott Keeney
Scott Keeney Memorial Sloan Kettering Cancer Center
Kathryn V. Anderson
Kathryn V. Anderson Memorial Sloan Kettering Cancer Center

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