D-Index & Metrics Best Publications

D-Index & Metrics

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Biology and Biochemistry D-index 71 Citations 15,214 127 World Ranking 2949 National Ranking 1522

Overview

What is he best known for?

The fields of study he is best known for:

  • Enzyme
  • Gene
  • DNA

Christopher D. Lima mainly focuses on Biochemistry, Ubiquitin, SUMO enzymes, RNA and SUMO protein. Biochemistry is often connected to Cell biology in his work. His study looks at the relationship between Cell biology and fields such as Ubiquitin-conjugating enzyme, as well as how they intersect with chemical problems.

The various areas that Christopher D. Lima examines in his RNA study include DNA Ligases, Messenger RNA and Active site. Christopher D. Lima has included themes like RanGAP and Yeast in his SUMO protein study. His Small Ubiquitin-Related Modifier Proteins research includes themes of Sumoylation Pathway and SUMO2.

His most cited work include:

  • The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition. (763 citations)
  • Ulp1-SUMO Crystal Structure and Genetic Analysis Reveal Conserved Interactions and a Regulatory Element Essential for Cell Growth in Yeast (565 citations)
  • Structural basis for E2-mediated SUMO conjugation revealed by a complex between ubiquitin-conjugating enzyme Ubc9 and RanGAP1. (477 citations)

What are the main themes of his work throughout his whole career to date?

Christopher D. Lima mainly investigates Biochemistry, Cell biology, RNA, Ubiquitin and Exosome complex. His study in SUMO enzymes, Enzyme, Protein structure, SUMO protein and DNA ligase falls within the category of Biochemistry. His work carried out in the field of Cell biology brings together such families of science as Exosome, Exoribonuclease activity, Schizosaccharomyces pombe, Polyadenylation and RNA Helicase A.

His RNA research incorporates elements of Molecular biology and Messenger RNA. His study in Ubiquitin is interdisciplinary in nature, drawing from both Thioester and Plasma protein binding. His Exosome complex research is multidisciplinary, incorporating elements of Exoribonuclease, Exosome Multienzyme Ribonuclease Complex and TRAMP complex.

He most often published in these fields:

  • Biochemistry (64.94%)
  • Cell biology (40.80%)
  • RNA (30.46%)

What were the highlights of his more recent work (between 2014-2021)?

  • Cell biology (40.80%)
  • Exosome complex (24.71%)
  • RNA (30.46%)

In recent papers he was focusing on the following fields of study:

His scientific interests lie mostly in Cell biology, Exosome complex, RNA, Biochemistry and Exosome. His Cell biology research includes elements of Schizosaccharomyces pombe and RNA Helicase A. Christopher D. Lima works mostly in the field of Exosome complex, limiting it down to topics relating to Exoribonuclease and, in certain cases, In vitro, as a part of the same area of interest.

As a part of the same scientific study, Christopher D. Lima usually deals with the RNA, concentrating on Messenger RNA and frequently concerns with Molecular biology. In general Biochemistry, his work in Phosphorylation, Transcription Elongation Factor SPT5 and Threonine is often linked to RNA polymerase II and CTD linking many areas of study. His research integrates issues of Cytoplasm, Ribonuclease and Recombinant DNA in his study of Exosome.

Between 2014 and 2021, his most popular works were:

  • Ubiquitin-like Protein Conjugation: Structures, Chemistry, and Mechanism (153 citations)
  • Targeting RNA for processing or destruction by the eukaryotic RNA exosome and its cofactors (113 citations)
  • Targeting RNA for processing or destruction by the eukaryotic RNA exosome and its cofactors (113 citations)

In his most recent research, the most cited papers focused on:

  • Enzyme
  • Gene
  • DNA

His primary scientific interests are in Cell biology, Biochemistry, Ubiquitin, RNA and Exosome complex. His Cell biology study integrates concerns from other disciplines, such as Mutant, Germline, Gene duplication, Regulation of gene expression and RNA Helicase A. His work is connected to Ubiquitin ligase, Ubiquitin-Protein Ligases and SUMO enzymes, as a part of Biochemistry.

The SUMO enzymes study combines topics in areas such as Structural biology, DNA ligase, Stereochemistry, SUMO2 and SUMO-1 Protein. In general Ubiquitin study, his work on ISG15 often relates to the realm of ATG12, thereby connecting several areas of interest. His studies in Small nuclear RNA integrate themes in fields like Exosome Multienzyme Ribonuclease Complex, Messenger RNA, Molecular biology and Exoribonuclease complex.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition.

Jaclyn R. Gareau;Christopher D. Lima.
Nature Reviews Molecular Cell Biology (2010)

984 Citations

Ulp1-SUMO Crystal Structure and Genetic Analysis Reveal Conserved Interactions and a Regulatory Element Essential for Cell Growth in Yeast

Elena Mossessova;Christopher D Lima.
Molecular Cell (2000)

743 Citations

Structural basis for E2-mediated SUMO conjugation revealed by a complex between ubiquitin-conjugating enzyme Ubc9 and RanGAP1.

Victor Bernier-Villamor;Deborah A. Sampson;Michael J. Matunis;Christopher D. Lima.
Cell (2002)

646 Citations

Reconstitution, Activities, and Structure of the Eukaryotic RNA Exosome

Quansheng Liu;Jaclyn C. Greimann;Christopher D. Lima.
Cell (2006)

581 Citations

Insights into E3 ligase activity revealed by a SUMO–RanGAP1–Ubc9–Nup358 complex

David Reverter;Christopher D. Lima.
Nature (2005)

475 Citations

Metabolic enzymes of mycobacteria linked to antioxidant defense by a thioredoxin-like protein.

R. Bryk;C. D. Lima;H. Erdjument-Bromage;P. Tempst;P. Tempst.
Science (2002)

433 Citations

Three-dimensional structure of the 67K N-terminal fragment of E. coli DNA topoisomerase I

Christopher D. Lima;James C. Wang;Alfonso Mondragón;Alfonso Mondragón.
Nature (1994)

345 Citations

Structures of the SUMO E1 provide mechanistic insights into SUMO activation and E2 recruitment to E1

Luisa Maria Lois;Christopher D Lima.
The EMBO Journal (2005)

299 Citations

The RNA Exosome Targets the AID Cytidine Deaminase to Both Strands of Transcribed Duplex DNA Substrates

Uttiya Basu;Uttiya Basu;Fei-Long Meng;Celia Keim;Veronika Grinstein.
Cell (2011)

283 Citations

Structure of an mRNA capping enzyme bound to the phosphorylated carboxy-terminal domain of RNA polymerase II.

Carme Fabrega;Vincent Shen;Stewart Shuman;Christopher D. Lima.
Molecular Cell (2003)

262 Citations

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