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D-Index & Metrics

Biology and Biochemistry

D-Index
57
Citations
9247
World Ranking
14060
National Ranking
5928

Overview

Beate Schwer is affiliated with Cornell University in the United States and has contributed extensively to the field of Biochemistry, Genetics, and Molecular Biology, with a specific focus on molecular biology. Their research portfolio includes 64 publications, predominantly in the subfield of Molecular Biology, alongside notable work in Cell Biology, Renewable Energy, Sustainability and the Environment, Infectious Diseases, and Nutrition and Dietetics.

Schwer's research concentrates on fungal and yeast genetics, RNA research and splicing, and mechanisms of RNA and protein synthesis. Additional areas of interest include endoplasmic reticulum stress and disease, RNA modifications and cancer, as well as metalloenzymes and iron-sulfur proteins, and protein kinase regulation and GTPase signaling.

The scientist has contributed to several recent publications, including:

  • A genetic screen for suppressors of hyper-repression of the fission yeast PHO regulon by Pol2 CTD mutation T4A implicates inositol 1-pyrophosphates as agonists of precocious lncRNA transcription termination, 2020, Nucleic Acids Research
  • Cleavage-Polyadenylation Factor Cft1 and SPX Domain Proteins Are Agents of Inositol Pyrophosphate Toxicosis in Fission Yeast, 2022, mBio
  • Activities and Structure-Function Analysis of Fission Yeast Inositol Pyrophosphate (IPP) Kinase-Pyrophosphatase Asp1 and Its Impact on Regulation of pho1 Gene Expression, 2022, mBio
  • Genetic screen for suppression of transcriptional interference identifies a gain-of-function mutation in Pol2 termination factor Seb1, 2021, Proceedings of the National Academy of Sciences
  • Genetic interactions and transcriptomics implicate fission yeast CTD prolyl isomerase Pin1 as an agent of RNA 3' processing and transcription termination that functions via its effects on CTD phosphatase Ssu72, 2020, Nucleic Acids Research

Frequent co-authors collaborating with Schwer include:

  • Stewart Shuman
  • Ana M. Sánchez
  • Angad Garg
  • Henning J. Jessen
  • Bradley Benjamin

Schwer has published extensively in venues such as:

  • mBio
  • RNA
  • Nucleic Acids Research
  • Journal of Biological Chemistry
  • Proceedings of the National Academy of Sciences

Best Publications

  • Dynamic association of capping enzymes with transcribing RNA polymerase II

    Stephanie C. Schroeder;Beate Schwer;Stewart Shuman;David Bentley

  • PRP16 is an RNA-dependent ATPase that interacts transiently with the spliceosome.

    Beate Schwer;Christine Guthrie

  • Prp22, a DExH-box RNA helicase, plays two distinct roles in yeast pre-mRNA splicing

    Beate Schwer;Christian H. Gross

  • RNA capping enzyme and DNA ligase: a superfamily of covalent nucleotidyl transferases.

    Stewart Shuman;Beate Schwer

  • A conformational rearrangement in the spliceosome is dependent on PRP16 and ATP hydrolysis.

    B Schwer;C Guthrie

  • Prp43 is an essential RNA-dependent ATPase required for release of lariat-intron from the spliceosome.

    Arnold Martin;Susanne Schneider;Beate Schwer

  • A new twist on RNA helicases: DExH/D box proteins as RNPases

    Beate Schwer

  • Ntr1 activates the Prp43 helicase to trigger release of lariat-intron from the spliceosome.

    Naoko Tanaka;Anna Aronova;Beate Schwer

  • Deciphering the RNA Polymerase II CTD Code in Fission Yeast

    Beate Schwer;Stewart Shuman

  • The guanylyltransferase domain of mammalian mRNA capping enzyme binds to the phosphorylated carboxyl-terminal domain of RNA polymerase II.

    C. Kiong Ho;Verl Sriskanda;Susan McCracken;David Bentley

  • Discontinuous transcription or RNA processing of vaccinia virus late messengers results in a 5' poly(A) leader.

    Beate Schwer;Paolo Visca;Jan C. Vos;Hendrik G. Stunnenberg

  • A Conformational Rearrangement in the Spliceosome Sets the Stage for Prp22-Dependent mRNA Release

    Beate Schwer

  • Tat stimulates cotranscriptional capping of HIV mRNA.

    Ya-Lin Chiu;C.Kiong Ho;Nayanendu Saha;Beate Schwer

  • TFIIH and P-TEFb Coordinate Transcription with Capping Enzyme Recruitment at Specific Genes in Fission Yeast

    Laia Viladevall;Laia Viladevall;Courtney V. St. Amour;Courtney V. St. Amour;Courtney V. St. Amour;Adam Rosebrock;Susanne Schneider

  • Accelerated mRNA decay in conditional mutants of yeast mRNA capping enzyme

    Beate Schwer;Xiangdong Mao;Stewart Shuman

  • Yeast mRNA cap methyltransferase is a 50-kilodalton protein encoded by an essential gene.

    Xiangdong Mao;B. Schwer;S. Shuman

  • SLU7 and a novel activity, SSF1, act during the PRP16-dependent step of yeast pre-mRNA splicing.

    Athar Ansari;B. Schwer

  • RNA helicase dynamics in pre‐mRNA splicing

    Beate Schwer;Tamar Meszaros

  • Covalent catalysis in nucleotidyl transfer reactions: essential motifs in Saccharomyces cerevisiae RNA capping enzyme are conserved in Schizosaccharomyces pombe and viral capping enzymes and among polynucleotide ligases

    Stewart Shuman;Yizhi Liu;Beate Schwer

  • How Slu7 and Prp18 cooperate in the second step of yeast pre-mRNA splicing.

    Shelly-Ann James;William Turner;Beate Schwer

Frequent Co-Authors

Stewart Shuman
Stewart Shuman Memorial Sloan Kettering Cancer Center
Robert P. Fisher
Robert P. Fisher Icahn School of Medicine at Mount Sinai
Christopher D. Lima
Christopher D. Lima Memorial Sloan Kettering Cancer Center
David Bentley
David Bentley University of Colorado Denver
Hendrik G. Stunnenberg
Hendrik G. Stunnenberg Radboud University
Masad J. Damha
Masad J. Damha McGill University
Kevan M. Shokat
Kevan M. Shokat University of California, San Francisco
Christine Guthrie
Christine Guthrie University of California, San Francisco
Charles Boone
Charles Boone University of Toronto
Michael Costanzo
Michael Costanzo University of Toronto

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