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Molecular Biology

D-Index
59
Citations
11884
World Ranking
2023
National Ranking
162

Research.com Recognitions

  • 2000 - Member of Academia Europaea
  • 1998 - Fellow of the Royal Society, United Kingdom
  • 1995 - Fellow of the Royal Society of Edinburgh

Overview

Jean D. Beggs is affiliated with the University of Edinburgh in the United Kingdom. Their research spans various areas within biochemistry, genetics, molecular biology, and medicine, with a focus on molecular biology and immunology. The investigations notably cover RNA research and splicing, cytokine signaling pathways and interactions, and neutrophil-related oxidative mechanisms.

The scientist's work has contributed to understanding RNA and protein synthesis mechanisms, RNA modifications in cancer, interferon and immune responses, and chromatin dynamics. These topics reflect their interest in both fundamental molecular processes and the molecular basis of immune and inflammatory diseases.

Jean D. Beggs has coauthored multiple papers with several frequent collaborators, including Michele Fresneda Alarcon, Genna Ali Abdullah, Isobel Kynoch, Andrew Sellin, and Andrew Cross.

Recent publications highlight their ongoing research activities. These include:

  • "Revisiting the window of opportunity for cotranscriptional splicing in budding yeast," 2020, published in RNA
  • "Conditional depletion of transcriptional kinases Ctk1 and Bur1 and effects on co-transcriptional spliceosome assembly and pre-mRNA splicing," 2021, published in RNA Biology
  • "The complexity of transferring genetic information," 2023, published in Molecular Cell
  • "Complexity of the neutrophil transcriptome in early and severe rheumatoid arthritis: a role for microRNAs?", 2025, published in Journal of Leukocyte Biology
  • "Complexity of the neutrophil transcriptome in early and severe rheumatoid arthritis. A role for microRNAs?", 2024, published in bioRxiv (Cold Spring Harbor Laboratory)

Their frequent publication venues demonstrate a consistent engagement with journals specialized in RNA biology and immunology, such as RNA, RNA Biology, Molecular Cell, Journal of Leukocyte Biology, and bioRxiv.

Jean D. Beggs has been recognized with multiple prestigious honors during their career. These include:

  • Member of Academia Europaea (2000)
  • Fellow of the Royal Society, United Kingdom (1998)
  • Fellow of the Royal Society of Edinburgh (1995)

Best Publications

  • Transformation of yeast by a replicating hybrid plasmid

    Jean D. Beggs

  • Yeast Sm-like proteins function in mRNA decapping and decay

    Sundaresan Tharun;Weihai He;Andrew E. Mayes;Pascal Lennertz

  • Prp8 protein: At the heart of the spliceosome

    Richard J. Grainger;Jean D. Beggs

  • The Construction in vitro of Transducing Derivatives of Phage Lambda

    Kathleen Borck;Jean D. Beggs;W. J. Brammar;A. S. Hopkins

  • Cross-linking, ligation, and sequencing of hybrids reveals RNA–RNA interactions in yeast

    Grzegorz Kudla;Sander Granneman;Daniela Hahn;Jean D. Beggs

  • Characterization of Sm‐like proteins in yeast and their association with U6 snRNA

    Andrew E Mayes;Loredana Verdone;Pierre Legrain;Jean D Beggs

  • Splicing-Dependent RNA Polymerase Pausing in Yeast

    Ross D. Alexander;Steven A. Innocente;J. David Barrass;Jean D. Beggs

  • Genome-wide protein interaction screens reveal functional networks involving Sm-like proteins.

    Micheline Fromont-Racine;Andrew E. Mayes;Adeline Brunet-Simon;Jean-Christophe Rain

  • A role for Q/N-rich aggregation-prone regions in P-body localization

    Martin A. M. Reijns;Ross D. Alexander;Michael P. Spiller;Michael P. Spiller;Jean D. Beggs

  • Identification of a yeast snRNP protein and detection of snRNP-snRNP interactions

    Marie Lossky;Gordon J. Anderson;Steve P. Jackson;Jean Beggs

  • Extensive interactions of PRP8 protein with the 5' and 3' splice sites during splicing suggest a role in stabilization of exon alignment by U5 snRNA

    S Teigelkamp;A J Newman;J D Beggs

  • Functional contacts with a range of splicing proteins suggest a central role for Brr2p in the dynamic control of the order of events in spliceosomes of Saccharomyces cerevisiae.

    van, Nues, Rw;JD Beggs

  • Vac14 controls PtdIns(3,5)P(2) synthesis and Fab1-dependent protein trafficking to the multivesicular body.

    Stephen K. Dove;Robert K. McEwen;Andrew Mayes;David C. Hughes

  • Identification and characterization of Uss1p (Sdb23p): a novel U6 snRNA-associated protein with significant similarity to core proteins of small nuclear ribonucleoproteins.

    M Cooper;L H Johnston;J D Beggs

  • Expression of human glutathione S-transferases in Saccharomyces cerevisiae confers resistance to the anticancer drugs adriamycin and chlorambucil

    S M Black;J D Beggs;J D Hayes;A Bartoszek

  • Abnormal expression of chromosomal rabbit |[beta]|-globin gene in Saccharomyces cerevisiae

    Jean D. Beggs;Johan van den Berg;Albert van Ooyen;Charles Weissmann

  • Lsm proteins and RNA processing.

    J.D. Beggs

  • RNA helicases in splicing.

    Olivier Cordin;Jean D. Beggs

  • Characterization of U6 snRNA-protein interactions.

    Valerie P.I. Vidal;Loredana Verdone;Andrew E. Mayes;Jean D. Beggs

  • A suppressor of a yeast splicing mutation (prp8-1) encodes a putative ATP-dependent RNA helicase.

    Derek J. Jamieson;Bryan Rahe;Bryan Rahe;John Pringle;Jean D Beggs

Frequent Co-Authors

David Tollervey
David Tollervey University of Edinburgh
Martin Kupiec
Martin Kupiec Tel Aviv University
Juri Rappsilber
Juri Rappsilber Technical University of Berlin
Chris F. Inglehearn
Chris F. Inglehearn University of Leeds
David A. Mackey
David A. Mackey University of Western Australia
Reinhard Lührmann
Reinhard Lührmann Max Planck Society
Stephen P. Jackson
Stephen P. Jackson University of Cambridge
C. Roland Wolf
C. Roland Wolf University of Dundee
Eric A. Pierce
Eric A. Pierce Massachusetts Eye and Ear Infirmary
Guido Sanguinetti
Guido Sanguinetti International School for Advanced Studies

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