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Biology and Biochemistry

D-Index
63
Citations
16413
World Ranking
10098
National Ranking
774

Overview

Kiyoshi Nagai is a researcher affiliated with the MRC Laboratory of Molecular Biology in the United Kingdom. Their work spans several main fields including Biochemistry, Genetics and Molecular Biology, as well as Engineering. The primary subfields of study include Molecular Biology, Cognitive Neuroscience, Industrial and Manufacturing Engineering, Control and Systems Engineering, and Biomedical Engineering.

The main topics of Nagai's research cover RNA Research and Splicing, RNA and protein synthesis mechanisms, Genomics and Chromatin Dynamics, RNA modifications and cancer, Visual perception and processing mechanisms, Neural and Behavioral Psychology Studies, and Motor Control and Adaptation.

Among the frequent co-authors who have collaborated with Nagai are Sebastian M. Fica, Takeshi Sakurada, Max E. Wilkinson, Wojciech P. Galej, and Lisa M. Strittmatter.

Publication venues where Nagai's work has regularly appeared include The Proceedings of JSME annual Conference on Robotics and Mechatronics (Robomec), bioRxiv (Cold Spring Harbor Laboratory), Japanese Journal of Oral & Maxillofacial Surgery, Molecular Cell, and Nature Communications.

Selected recent papers authored or co-authored by Nagai showcase a focus on molecular and biochemical mechanisms:

  • Solid-state 1H and 13C NMR studies of new ionic plastic-crystals with branched structures: [NEtxMe(3−x)(i-Pr)][BEt(4−y)Mey] (x = 1-3, y = 0, 1), 2024, Physical Chemistry Chemical Physics
  • Individual Optimal Attentional Strategy in Motor Learning Tasks Characterized by Steady-State Somatosensory and Visual Evoked Potentials, 2022, Frontiers in Human Neuroscience
  • Structural basis for conformational equilibrium of the catalytic spliceosome, 2021, Molecular Cell
  • psiCLIP reveals dynamic RNA binding by DEAH-box helicases before and after exon ligation, 2021, Nature Communications
  • PsiCLIP reveals dynamic RNA binding by DEAH-box helicases before and after exon ligation, 2020, bioRxiv (Cold Spring Harbor Laboratory)

Best Publications

  • Crystal structure at 1.92 A resolution of the RNA-binding domain of the U1A spliceosomal protein complexed with an RNA hairpin.

    Oubridge C;Ito N;Ito N;Evans Pr;Teo Ch;Teo Ch

  • Crystal structure of the RNA-binding domain of the U1 small nuclear ribonucleoprotein A

    Kiyoshi Nagai;Chris Oubridge;Timm H. Jessen;Jade Li

  • Generation of β -globin by sequence-specific proteolysis of a hybrid protein produced in Escherichia coli

    Kiyoshi Nagai;Hans Christian Thøgersen

  • Synthesis and sequence-specific proteolysis of hybrid proteins produced in Escherichia coli.

    Kiyoshi Nagai;Hans Christian Thøgersen

  • RNA Splicing by the Spliceosome

    Max E Wilkinson;Clément Charenton;Kiyoshi Nagai

  • Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs.

    Christian Kambach;Stefan Walke;Robert Young;Johanna M. Avis

  • Crystal structure of human spliceosomal U1 snRNP at 5.5 Å resolution

    Daniel A. Pomeranz Krummel;Chris Oubridge;Adelaine Leung;Jade Li

  • Crystal structure of the spliceosomal U2B″–U2A′ protein complex bound to a fragment of U2 small nuclear RNA

    Stephen R. Price;Philip R. Evans;Kiyoshi Nagai

  • RNA recognition by RNP proteins during RNA processing.

    Gabriele Varani;Kiyoshi Nagai

  • Specificity of ribonucleoprotein interaction determined by RNA folding during complex formation

    Frédéric H.-T. Allain;Charles C. Gubser;Peter W. A. Howe;Kiyoshi Nagai

  • The role of the distal histidine in myoglobin and haemoglobin

    John S. Olson;Antony J. Mathews;Ronald J. Rohlfs;Barry A. Springer

  • Oxygen binding properties of human mutant hemoglobins synthesized in Escherichia coli

    Kiyoshi Nagai;Max F. Perutz;Claude Poyart

  • The RNP domain: a sequence-specific RNA-binding domain involved in processing and transport of RNA.

    Kiyoshi Nagai;Chris Oubridge;Nobutoshi Ito;Johanna Avis

  • RNA—protein complexes

    Kiyoshi Nagai

  • Recognition of a signal peptide by the signal recognition particle

    Claudia Y. Janda;Jade Li;Chris Oubridge;Helena Hernández;Helena Hernández

  • Crystal structure of Prp8 reveals active site cavity of the spliceosome

    Wojciech P. Galej;Chris Oubridge;Andrew J. Newman;Kiyoshi Nagai

  • Crystal structure of human U1 snRNP, a small nuclear ribonucleoprotein particle, reveals the mechanism of 5′ splice site recognition

    Yasushi Kondo;Chris Oubridge;Anne-Marie M van Roon;Kiyoshi Nagai

  • Crystallization of RNA-protein complexes I. Methods for the large-scale preparation of RNA suitable for crystallographic studies

    Stephen R. Price;Nobutoshi Ito;Chris Oubridge;Johanna M. Avis

  • Cryo-EM structure of the spliceosome immediately after branching

    Wojciech P. Galej;Max E. Wilkinson;Sebastian M. Fica;Chris Oubridge

  • Identification of molecular contacts between the U1 A small nuclear ribonucleoprotein and U1 RNA.

    T.H. Jessen;C. Oubridge;C.H. Teo;C. Pritchard

Frequent Co-Authors

Jeremy R. H. Tame
Jeremy R. H. Tame Yokohama City University
Nicholas M. Luscombe
Nicholas M. Luscombe The Francis Crick Institute
Ben F. Luisi
Ben F. Luisi University of Cambridge
Wolfgang Bermel
Wolfgang Bermel University of Florence
John S. Olson
John S. Olson Rice University
Max F. Perutz
Max F. Perutz University of Cambridge
Jernej Ule
Jernej Ule The Francis Crick Institute
Gabriele Varani
Gabriele Varani University of Washington
Carol V. Robinson
Carol V. Robinson University of Oxford
Bertrand Séraphin
Bertrand Séraphin Institute of Genetics and Molecular and Cellular Biology

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