Member of the European Molecular Biology Organization (EMBO)
Nicholas M. Luscombe spends much of his time researching Genetics, Transcription factor, Computational biology, Gene and Regulation of gene expression. Genome, Human genome, Chromatin, Protein family and Promoter are among the areas of Genetics where Nicholas M. Luscombe concentrates his study. In Genome, he works on issues like Conserved sequence, which are connected to Function, Molecular evolution and Genomic organization.
His studies deal with areas such as Transcription, Systematic evolution of ligands by exponential enrichment and Gene regulatory network as well as Transcription factor. Nicholas M. Luscombe interconnects RNA, Small nucleolar RNA, BAP1 and Functional genomics in the investigation of issues within Computational biology. The various areas that Nicholas M. Luscombe examines in his Regulation of gene expression study include Enhancer and Gene expression.
Nicholas M. Luscombe focuses on Computational biology, Genetics, Genome, Gene and Cell biology. His work carried out in the field of Computational biology brings together such families of science as Gene expression, RNA, Yeast, Chromatin and DNA sequencing. His Chromatin study which covers Transcription that intersects with RNA polymerase II.
His research in Genome is mostly concerned with Human genome. His Gene research integrates issues from Cell and Embryo. Nicholas M. Luscombe has included themes like Transcriptome, Cell fate determination, RNA-binding protein and Intron in his Cell biology study.
His main research concerns Computational biology, Genome, Chromatin, Cell biology and RNA. His study in Computational biology is interdisciplinary in nature, drawing from both Transcriptome, Yeast, Gene, DNA repair and Genome editing. His Genome study incorporates themes from Evolutionary biology and Nucleosome.
Nucleosome is the subject of his research, which falls under Genetics. In his study, Gene expression and ENCODE is inextricably linked to Transcription, which falls within the broad field of Chromatin. His Cell biology research is multidisciplinary, incorporating perspectives in Translation, RNA-binding protein and Intron.
His scientific interests lie mostly in Computational biology, Chromatin, Genome, Transcription and RNA. His study in Computational biology is interdisciplinary in nature, drawing from both Transcriptome, Gene, splice, Small nuclear ribonucleoprotein and ICLIP. His Chromatin study combines topics in areas such as Genome editing, DNA repair and Cell biology.
His Genome study combines topics from a wide range of disciplines, such as Chromatin remodeling and CRISPR. The various areas that Nicholas M. Luscombe examines in his RNA study include ENCODE and Nanopore sequencing. Nicholas M. Luscombe interconnects Regulation of gene expression, Nuclear localization sequence and DNA in the investigation of issues within ENCODE.
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An integrated encyclopedia of DNA elements in the human genome
Ian Dunham;Anshul Kundaje;Shelley F. Aldred;Patrick J. Collins.
A census of human transcription factors: function, expression and evolution
Juan M. Vaquerizas;Sarah K. Kummerfeld;Sarah K. Kummerfeld;Sarah A. Teichmann;Nicholas M. Luscombe;Nicholas M. Luscombe.
Nature Reviews Genetics (2009)
A User's Guide to the Encyclopedia of DNA Elements (ENCODE)
Richard M. Myers;John Stamatoyannopoulos;Michael Snyder;Ian Dunham.
PLOS Biology (2011)
Genomic analysis of regulatory network dynamics reveals large topological changes
Nicholas M. Luscombe;M. Madan Babu;Haiyuan Yu;Michael Snyder.
DNA-Binding Specificities of Human Transcription Factors
Arttu Jolma;Jian Yan;Thomas Whitington;Jarkko Toivonen.
iCLIP reveals the function of hnRNP particles in splicing at individual nucleotide resolution
Julian König;Kathi Zarnack;Gregor Rot;Tomaž Curk.
Nature Structural & Molecular Biology (2010)
Amino acid–base interactions: a three-dimensional analysis of protein–DNA interactions at an atomic level
Nicholas M. Luscombe;Roman A. Laskowski;Janet M. Thornton.
Nucleic Acids Research (2001)
Structure and evolution of transcriptional regulatory networks.
M Madan Babu;Nicholas M Luscombe;L Aravind;Mark Gerstein.
Current Opinion in Structural Biology (2004)
Mapping long-range promoter contacts in human cells with high-resolution capture Hi-C
Borbala Mifsud;Filipe Tavares-Cadete;Alice N Young;Robert Sugar.
Nature Genetics (2015)
An overview of the structures of protein-DNA complexes
Nicholas M Luscombe;Susan E Austin;Helen M Berman;Janet M Thornton;Janet M Thornton.
Genome Biology (2000)
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