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Alexander Tzagoloff

Alexander Tzagoloff

D-Index & Metrics

Chemistry

D-Index
97
Citations
26976
World Ranking
1496
National Ranking
573

Genetics

D-Index
99
Citations
31310
World Ranking
786
National Ranking
393

Overview

Alexander Tzagoloff is affiliated with Columbia University in the United States and conducts research primarily in the field of Biochemistry, Genetics and Molecular Biology. Their work has a strong focus on Molecular Biology, with a substantial portion dedicated to topics related to mitochondrial function, ATP synthase, and related metabolic processes.

Their main research interests encompass several interconnected topics:

  • ATP Synthase and ATPases Research
  • Mitochondrial Function and Pathology
  • Photosynthetic Processes and Mechanisms
  • Metalloenzymes and iron-sulfur proteins
  • Metabolism and Genetic Disorders

Tzagoloff has contributed to multiple publications across respected scientific venues, indicating a diverse research portfolio. The frequent publication venues include:

  • Biological Chemistry
  • PLoS ONE
  • Life Science Alliance

Among their recent scholarly articles are the following works:

  • "Modular assembly of yeast mitochondrial ATP synthase and cytochrome oxidase," published in 2020 in Biological Chemistry
  • "Atco, a yeast mitochondrial complex of Atp9 and Cox6, is an assembly intermediate of the ATP synthase," published in 2020 in PLoS ONE
  • "Allotopic expression of COX6 elucidates Atco-driven co-assembly of cytochrome oxidase and ATP synthase," published in 2023 in Life Science Alliance

Throughout their research career, Tzagoloff has collaborated frequently with several co-authors, including:

  • Letícia Veloso Ribeiro Franco
  • Chen-Hsien Su
  • Lorisa Simas Teixeira
  • Chen Su
  • Julia Burnett

The body of work indicates a focus on the assembly and function of mitochondrial complexes, especially the ATP synthase complex and cytochrome oxidase, which are crucial for understanding cellular energy metabolism and mitochondrial biology.

Overall, Alexander Tzagoloff's research addresses fundamental aspects of molecular biology related to energy production in cells, mitochondrial architecture, and the biochemical mechanisms underlying these processes.

Best Publications

  • [45] Cytochrome oxidase from beef heart mitochondria

    David C. Wharton;Alexander Tzagoloff

  • Yeast/E. coli shuttle vectors with multiple unique restriction sites

    John E. Hill;Alan M. Myers;T. J. Koerner;Alexander Tzagoloff

  • SDHA is a tumor suppressor gene causing paraganglioma

    Nelly Burnichon;Jean-Jacques Brière;Rossella Libé;Laure Vescovo

  • Assembly of the mitochondrial membrane system. IV. Role of mitochondrial and cytoplasmic protein synthesis in the biosynthesis of the rutamycin-sensitive adenosine triphosphatase.

    Alexander Tzagoloff

  • Yeast shuttle and integrative vectors with multiple cloning sites suitable for construction of lacZ fusions.

    Alan M. Myers;Alexander Tzagoloff;Dennis M. Kinney;Carol J. Lusty

  • PET genes of Saccharomyces cerevisiae.

    A Tzagoloff;C L Dieckmann

  • Characterization of COX17, a Yeast Gene Involved in Copper Metabolism and Assembly of Cytochrome Oxidase

    D. Moira Glerum;Andrey Shtanko;Alexander Tzagoloff

  • GENETICS OF MITOCHONDRIAL BIOGENESIS

    Alexander Tzagoloff;Alan M. Myers

  • Assembly of the mitochondrial membrane system. Structure and nucleotide sequence of the gene coding for subunit 1 of yeast cytochrme oxidase.

    S. G. Bonitz;Gloria Coruzzi;B. E. Thalenfeld;A. Tzagoloff

  • Assembly of the mitochondrial membrane system. CBP6, a yeast nuclear gene necessary for synthesis of cytochrome b.

    C L Dieckmann;A Tzagoloff

  • Assembly of the mitochondrial membrane system. DNA sequence and organization of the cytochrome b gene in Saccharomyces cerevisiae D273-10B.

    F G Nobrega;A Tzagoloff

  • High-expression vectors with multiple cloning sites for construction of trpE fusion genes: pATH vectors.

    T.J. Koerner;John E. Hill;Alan M. Myers;Alexander Tzagoloff

  • SCO1 and SCO2 Act as High Copy Suppressors of a Mitochondrial Copper Recruitment Defect in Saccharomyces cerevisiae

    Glerum Dm;Shtanko A;Tzagoloff A

  • Codon recognition rules in yeast mitochondria

    Susan G. Bonitz;Roberta Berlani;Gloria Coruzzi;May Li

  • A mutant mitochondrial respiratory chain assembly protein causes complex III deficiency in patients with tubulopathy, encephalopathy and liver failure

    Pascale De Lonlay;Isabelle Valnot;Antoni Barrientos;Marina Gorbatyuk

  • A mutation in the human heme A:farnesyltransferase gene (COX10 ) causes cytochrome c oxidase deficiency

    Isabelle Valnot;Jürgen Christoph Von Kleist-Retzow;Antonio Barrientos;Marina Gorbatyuk

  • Mitochondrial protein synthesis is required for maintenance of intact mitochondrial genomes in Saccharomyces cerevisiae.

    A M Myers;L K Pape;A Tzagoloff

  • Studies on the mitochondrial adenosine triphosphatase system. IV. Purification and characterization of the oligomycin sensitivity conferring protein.

    David H. MacLennan;Alexander. Tzagoloff

  • Assembly of the Mitochondrial Membrane System V. PROPERTIES OF A DISPERSED PREPARATION OF THE RUTAMYCIN-SENSITIVE ADENOSINE TRIPHOSPHATASE OF YEAST MITOCHONDRIA

    Alexander Tzagoloff;Pauline Meagher

  • Purification, Characterization, and Localization of Yeast Cox17p, a Mitochondrial Copper Shuttle

    John Beers;D. Moira Glerum;Alexander Tzagoloff

  • Biosynthesis of mitochondrial enzymes

    Alexander Tzagoloff;Meryl S. Rubin;Marcelino F. Sierra

Frequent Co-Authors

Giuseppe Macino
Giuseppe Macino Sapienza University of Rome
Antoni Barrientos
Antoni Barrientos University of Miami
Alan M. Myers
Alan M. Myers Iowa State University
Mian Wu
Mian Wu University of Science and Technology of China
Gloria M. Coruzzi
Gloria M. Coruzzi New York University
David E. Green
David E. Green University of Wisconsin–Madison
Catherine F. Clarke
Catherine F. Clarke University of California, Los Angeles
Françoise Foury
Françoise Foury Université Catholique de Louvain
Walter Neupert
Walter Neupert Max Planck Institute of Biochemistry

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