D-Index & Metrics Best Publications

D-Index & Metrics D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines.

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Genetics and Molecular Biology D-index 41 Citations 9,257 73 World Ranking 4991 National Ranking 179

Overview

What is he best known for?

The fields of study he is best known for:

  • Gene
  • DNA
  • Enzyme

His primary scientific interests are in Genetics, Saccharomyces cerevisiae, Gene, Computational biology and Synthetic genetic array. As a part of the same scientific study, Michael Costanzo usually deals with the Saccharomyces cerevisiae, concentrating on Epistasis and functional genomics and frequently concerns with Mutation, Fungal genetics, Genetic screen and Genetic redundancy. His work on Genome, Interactome, Gene isoform and Transcription factor as part of general Gene research is frequently linked to Open reading frame, bridging the gap between disciplines.

His work is dedicated to discovering how Computational biology, Gene interaction are connected with Yeast metabolism, Systems biology and Metabolic network and other disciplines. His work deals with themes such as Schizosaccharomyces pombe, Genetic Fitness and Gene mapping, which intersect with Synthetic genetic array. His studies in Gene mapping integrate themes in fields like Pleiotropy, Epistasis, Drosophila melanogaster, Mutation and Biological network.

His most cited work include:

  • The genetic landscape of a cell. (1828 citations)
  • A global genetic interaction network maps a wiring diagram of cellular function (665 citations)
  • CDK Activity Antagonizes Whi5, an Inhibitor of G1/S Transcription in Yeast (364 citations)

What are the main themes of his work throughout his whole career to date?

Genetics, Gene, Computational biology, Saccharomyces cerevisiae and Cell biology are his primary areas of study. His studies link Mutation with Gene. His Computational biology research includes elements of Gene mapping, Genetic interaction and Function.

The study incorporates disciplines such as Mutation, Epistasis and Mutant, Genetic screen in addition to Saccharomyces cerevisiae. His biological study spans a wide range of topics, including Chromatin, Histone H4 and Ubiquitin. Michael Costanzo interconnects Selectable marker, Genetic Fitness and Gene interaction in the investigation of issues within Synthetic genetic array.

He most often published in these fields:

  • Genetics (47.79%)
  • Gene (42.48%)
  • Computational biology (38.05%)

What were the highlights of his more recent work (between 2018-2021)?

  • Cell biology (26.55%)
  • Computational biology (38.05%)
  • Gene (42.48%)

In recent papers he was focusing on the following fields of study:

Michael Costanzo focuses on Cell biology, Computational biology, Gene, Saccharomyces cerevisiae and Ubiquitin. His Cell biology research is multidisciplinary, incorporating perspectives in Histone H4, Suppressor, Chromosome instability and Mutation. His Computational biology study incorporates themes from Phenotype, Genetic interaction, Genome and Genetic network.

The Fatty acid synthesis research he does as part of his general Gene study is frequently linked to other disciplines of science, such as ACACA, therefore creating a link between diverse domains of science. His Saccharomyces cerevisiae research integrates issues from Ribonucleotide reductase, Protein subunit, Mitochondrion and DNA replication. His Mutant study contributes to a more complete understanding of Genetics.

Between 2018 and 2021, his most popular works were:

  • Global Genetic Networks and the Genotype-to-Phenotype Relationship (68 citations)
  • Discovering genetic interactions bridging pathways in genome-wide association studies. (19 citations)
  • Exploring whole-genome duplicate gene retention with complex genetic interaction analysis. (14 citations)

In his most recent research, the most cited papers focused on:

  • Gene
  • DNA
  • Enzyme

His primary areas of study are Gene, Computational biology, Genotype, Phenotype and Cell biology. Michael Costanzo combines topics linked to Cancer cell with his work on Gene. Michael Costanzo has included themes like Genetic interaction, Genome, Human genome, Functional redundancy and Gene duplication in his Computational biology study.

His Genotype study combines topics in areas such as DECIPHER, Genetic network and Locus. His Phenotype research is multidisciplinary, relying on both Budding yeast, Allele and Function. He has researched Cell biology in several fields, including Histone, Cullin, De novo synthesis, Kinetochore and Genetic screen.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

The genetic landscape of a cell.

Michael Costanzo;Anastasia Baryshnikova;Jeremy Bellay;Yungil Kim.
Science (2010)

2362 Citations

A global genetic interaction network maps a wiring diagram of cellular function

Michael Costanzo;Benjamin VanderSluis;Elizabeth N. Koch;Anastasia Baryshnikova.
Science (2016)

735 Citations

CDK Activity Antagonizes Whi5, an Inhibitor of G1/S Transcription in Yeast

Michael Costanzo;Joy L Nishikawa;Joy L Nishikawa;Xiaojing Tang;Jonathan S Millman.
Cell (2004)

488 Citations

Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress

Johnny M. Tkach;Askar Yimit;Anna Y. Lee;Michael Riffle.
Nature Cell Biology (2012)

415 Citations

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing

Xinping Yang;Xinping Yang;Jasmin Coulombe-Huntington;Shuli Kang;Gloria M. Sheynkman.
Cell (2016)

346 Citations

Quantitative analysis of fitness and genetic interactions in yeast on a genome scale

Anastasia Baryshnikova;Michael Costanzo;Yungil Kim;Huiming Ding.
Nature Methods (2010)

338 Citations

Systematic exploration of essential yeast gene function with temperature-sensitive mutants

Zhijian Li;Franco J. Vizeacoumar;Sondra Bahr;Jingjing Li.
Nature Biotechnology (2011)

334 Citations

The Shwachman-Bodian-Diamond syndrome protein mediates translational activation of ribosomes in yeast.

Tobias F Menne;Tobias F Menne;Beatriz Goyenechea;Beatriz Goyenechea;Nuria Sánchez-Puig;Nuria Sánchez-Puig;Chi C Wong;Chi C Wong.
Nature Genetics (2007)

325 Citations

Systematic mapping of genetic interaction networks.

Scott J. Dixon;Michael Costanzo;Anastasia Baryshnikova;Brenda Andrews.
Annual Review of Genetics (2009)

314 Citations

Systematic Exploration of Synergistic Drug Pairs

Murat Çokol;Murat Çokol;Hon Nian Chua;Hon Nian Chua;Murat Taşan;Murat Taşan;Beste Mutlu.
Molecular Systems Biology (2011)

262 Citations

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