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Michael Costanzo

Michael Costanzo

D-Index & Metrics

Genetics

D-Index
60
Citations
16551
World Ranking
3131
National Ranking
115

Overview

Michael Costanzo is affiliated with the University of Toronto in Canada. Their main field of study is Biochemistry, Genetics and Molecular Biology, with a particular research focus on Molecular Biology, Genetics, Cell Biology, Oncology, and Plant Science. The scientist has contributed extensively to the understanding of genetic and molecular processes.

The research topics they have worked on include:

  • Fungal and yeast genetics research
  • Bioinformatics and Genomic Networks
  • CRISPR and Genetic Engineering
  • RNA and protein synthesis mechanisms
  • Ubiquitin and proteasome pathways
  • Mitochondrial Function and Pathology
  • Single-cell and spatial transcriptomics

Michael Costanzo's recent publications cover a range of areas mostly centered on genetic interactions and molecular mechanisms. Selected papers include:

  • "Exploring whole-genome duplicate gene retention with complex genetic interaction analysis," 2020, published in Science
  • "Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism," 2020, published in Nature Metabolism
  • "Environmental robustness of the global yeast genetic interaction network," 2021, published in Science
  • "Timer-based proteomic profiling of the ubiquitin-proteasome system reveals a substrate receptor of the GID ubiquitin ligase," 2021, published in Molecular Cell
  • "N-terminal acetylation shields proteins from degradation and promotes age-dependent motility and longevity," 2023, published in Nature Communications

Frequent collaborators include Charles Boone, Chad L. Myers, Brenda Andrews, Maximilian Billmann, and Jason Moffat.

Michael Costanzo has published in a variety of venues, with the most frequent being bioRxiv (Cold Spring Harbor Laboratory), Science, PLoS Genetics, The Journal of Cell Biology, and Nature Metabolism.

Best Publications

  • The genetic landscape of a cell.

    Michael Costanzo;Anastasia Baryshnikova;Jeremy Bellay;Yungil Kim

  • A global genetic interaction network maps a wiring diagram of cellular function

    Michael Costanzo;Benjamin VanderSluis;Elizabeth N. Koch;Anastasia Baryshnikova

  • CDK Activity Antagonizes Whi5, an Inhibitor of G1/S Transcription in Yeast

    Michael Costanzo;Joy L Nishikawa;Joy L Nishikawa;Xiaojing Tang;Jonathan S Millman

  • Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing

    Xinping Yang;Xinping Yang;Jasmin Coulombe-Huntington;Shuli Kang;Gloria M. Sheynkman

  • Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress

    Johnny M. Tkach;Askar Yimit;Anna Y. Lee;Michael Riffle

  • Evaluation and Design of Genome-Wide CRISPR/SpCas9 Knockout Screens.

    Traver Hart;Amy Hin Yan Tong;Katie Chan;Jolanda Van Leeuwen

  • Systematic exploration of essential yeast gene function with temperature-sensitive mutants

    Zhijian Li;Franco J. Vizeacoumar;Sondra Bahr;Jingjing Li

  • Quantitative analysis of fitness and genetic interactions in yeast on a genome scale

    Anastasia Baryshnikova;Michael Costanzo;Yungil Kim;Huiming Ding

  • The Shwachman-Bodian-Diamond syndrome protein mediates translational activation of ribosomes in yeast.

    Tobias F Menne;Beatriz Goyenechea;Beatriz Goyenechea;Nuria Sánchez-Puig;Nuria Sánchez-Puig;Chi C Wong;Chi C Wong

  • Systematic Exploration of Synergistic Drug Pairs

    Murat Çokol;Murat Çokol;Hon Nian Chua;Hon Nian Chua;Murat Taşan;Murat Taşan;Beste Mutlu

  • Systematic mapping of genetic interaction networks.

    Scott J. Dixon;Michael Costanzo;Anastasia Baryshnikova;Brenda Andrews

  • Uncoupling of GTP hydrolysis from eIF6 release on the ribosome causes Shwachman-Diamond syndrome

    Andrew J. Finch;Christine Hilcenko;Nicolas Basse;Lesley F. Drynan

  • Ubiquitin-related modifier Urm1 acts as a sulphur carrier in thiolation of eukaryotic transfer RNA

    Sebastian Leidel;Patrick G. A. Pedrioli;Tamara Bucher;Renée Brost

  • Global Gene Deletion Analysis Exploring Yeast Filamentous Growth

    Owen Ryan;Rebecca S. Shapiro;Christoph F. Kurat;David Mayhew

  • Systematic analysis of complex genetic interactions

    Elena Kuzmin;Benjamin VanderSluis;Wen Wang;Guihong Tan

  • An integrated approach to characterize genetic interaction networks in yeast metabolism

    Balázs Szappanos;Károly Kovács;Béla Szamecz;Frantisek Honti;Frantisek Honti

  • Synthetic genetic array (SGA) analysis in Saccharomyces cerevisiae and Schizosaccharomyces pombe.

    Anastasia Baryshnikova;Michael Costanzo;Scott Dixon;Franco J. Vizeacoumar

  • The interaction network of the chaperonin CCT

    Carien Dekker;Peter C Stirling;Elizabeth A McCormack;Heather Filmore

  • Molecular chaperone Hsp90 stabilizes Pih1/Nop17 to maintain R2TP complex activity that regulates snoRNA accumulation

    Rongmin Zhao;Yoshito Kakihara;Anna Gribun;Jennifer Huen

  • Data from: Systematic analysis of complex genetic interactions

    Elena Kuzmin;Benjamin VanderSluis;Wen Wang;Guihong Tan

Frequent Co-Authors

Charles Boone
Charles Boone University of Toronto
Brenda J. Andrews
Brenda J. Andrews University of Toronto
Chad L. Myers
Chad L. Myers University of Minnesota
Anne-Claude Gingras
Anne-Claude Gingras Lunenfeld-Tanenbaum Research Institute
Corey Nislow
Corey Nislow University of British Columbia
Grant W. Brown
Grant W. Brown University of Toronto
Guri Giaever
Guri Giaever University of British Columbia
Frederick P. Roth
Frederick P. Roth Lunenfeld-Tanenbaum Research Institute
Yoshikazu Ohya
Yoshikazu Ohya University of Tokyo
Jason Moffat
Jason Moffat University of Toronto

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