His primary scientific interests are in Genetics, Saccharomyces cerevisiae, Gene, Computational biology and Synthetic genetic array. As a part of the same scientific study, Michael Costanzo usually deals with the Saccharomyces cerevisiae, concentrating on Epistasis and functional genomics and frequently concerns with Mutation, Fungal genetics, Genetic screen and Genetic redundancy. His work on Genome, Interactome, Gene isoform and Transcription factor as part of general Gene research is frequently linked to Open reading frame, bridging the gap between disciplines.
His work is dedicated to discovering how Computational biology, Gene interaction are connected with Yeast metabolism, Systems biology and Metabolic network and other disciplines. His work deals with themes such as Schizosaccharomyces pombe, Genetic Fitness and Gene mapping, which intersect with Synthetic genetic array. His studies in Gene mapping integrate themes in fields like Pleiotropy, Epistasis, Drosophila melanogaster, Mutation and Biological network.
Genetics, Gene, Computational biology, Saccharomyces cerevisiae and Cell biology are his primary areas of study. His studies link Mutation with Gene. His Computational biology research includes elements of Gene mapping, Genetic interaction and Function.
The study incorporates disciplines such as Mutation, Epistasis and Mutant, Genetic screen in addition to Saccharomyces cerevisiae. His biological study spans a wide range of topics, including Chromatin, Histone H4 and Ubiquitin. Michael Costanzo interconnects Selectable marker, Genetic Fitness and Gene interaction in the investigation of issues within Synthetic genetic array.
Michael Costanzo focuses on Cell biology, Computational biology, Gene, Saccharomyces cerevisiae and Ubiquitin. His Cell biology research is multidisciplinary, incorporating perspectives in Histone H4, Suppressor, Chromosome instability and Mutation. His Computational biology study incorporates themes from Phenotype, Genetic interaction, Genome and Genetic network.
The Fatty acid synthesis research he does as part of his general Gene study is frequently linked to other disciplines of science, such as ACACA, therefore creating a link between diverse domains of science. His Saccharomyces cerevisiae research integrates issues from Ribonucleotide reductase, Protein subunit, Mitochondrion and DNA replication. His Mutant study contributes to a more complete understanding of Genetics.
His primary areas of study are Gene, Computational biology, Genotype, Phenotype and Cell biology. Michael Costanzo combines topics linked to Cancer cell with his work on Gene. Michael Costanzo has included themes like Genetic interaction, Genome, Human genome, Functional redundancy and Gene duplication in his Computational biology study.
His Genotype study combines topics in areas such as DECIPHER, Genetic network and Locus. His Phenotype research is multidisciplinary, relying on both Budding yeast, Allele and Function. He has researched Cell biology in several fields, including Histone, Cullin, De novo synthesis, Kinetochore and Genetic screen.
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The genetic landscape of a cell.
Michael Costanzo;Anastasia Baryshnikova;Jeremy Bellay;Yungil Kim.
A global genetic interaction network maps a wiring diagram of cellular function
Michael Costanzo;Benjamin VanderSluis;Elizabeth N. Koch;Anastasia Baryshnikova.
CDK Activity Antagonizes Whi5, an Inhibitor of G1/S Transcription in Yeast
Michael Costanzo;Joy L Nishikawa;Joy L Nishikawa;Xiaojing Tang;Jonathan S Millman.
Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress
Johnny M. Tkach;Askar Yimit;Anna Y. Lee;Michael Riffle.
Nature Cell Biology (2012)
Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing
Xinping Yang;Xinping Yang;Jasmin Coulombe-Huntington;Shuli Kang;Gloria M. Sheynkman.
Quantitative analysis of fitness and genetic interactions in yeast on a genome scale
Anastasia Baryshnikova;Michael Costanzo;Yungil Kim;Huiming Ding.
Nature Methods (2010)
Systematic exploration of essential yeast gene function with temperature-sensitive mutants
Zhijian Li;Franco J. Vizeacoumar;Sondra Bahr;Jingjing Li.
Nature Biotechnology (2011)
The Shwachman-Bodian-Diamond syndrome protein mediates translational activation of ribosomes in yeast.
Tobias F Menne;Tobias F Menne;Beatriz Goyenechea;Beatriz Goyenechea;Nuria Sánchez-Puig;Nuria Sánchez-Puig;Chi C Wong;Chi C Wong.
Nature Genetics (2007)
Systematic mapping of genetic interaction networks.
Scott J. Dixon;Michael Costanzo;Anastasia Baryshnikova;Brenda Andrews.
Annual Review of Genetics (2009)
Systematic Exploration of Synergistic Drug Pairs
Murat Çokol;Murat Çokol;Hon Nian Chua;Hon Nian Chua;Murat Taşan;Murat Taşan;Beste Mutlu.
Molecular Systems Biology (2011)
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