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Walid A. Houry

Walid A. Houry

D-Index & Metrics

Biology and Biochemistry

D-Index
58
Citations
14429
World Ranking
13035
National Ranking
445

Overview

Walid A. Houry is affiliated with the University of Toronto in Canada and has a significant body of work primarily focused on biochemistry, genetics, and molecular biology. Their research integrates molecular biology with various interdisciplinary fields such as geophysics, environmental chemistry, and materials chemistry.

The scientist's publication record emphasizes themes related to biochemical and molecular mechanisms along with environmental and earth sciences topics. Their main fields of study include:

  • Biochemistry, Genetics and Molecular Biology

Subfields explored in their work cover:

  • Molecular Biology
  • Geophysics
  • Environmental Chemistry
  • Materials Chemistry
  • Genetics

Their research touches on several main topics including:

  • Methane Hydrates and Related Phenomena
  • Seismic Waves and Analysis
  • Earthquake Detection and Analysis
  • Heat shock proteins research
  • Enzyme Structure and Function
  • RNA and protein synthesis mechanisms
  • Protein Structure and Dynamics

Walid A. Houry's recent papers highlight their focus on molecular mechanisms involving protein complexes and protease functions. Notable publications include:

  • "A processive rotary mechanism couples substrate unfolding and proteolysis in the ClpXP degradation machinery", 2020, eLife
  • "AAA+ proteins", 2020, Current Biology
  • "Recent structural insights into the mechanism of ClpP protease regulation by AAA+ chaperones and small molecules", 2022, Journal of Biological Chemistry
  • "Substrates and interactors of the ClpP protease in the mitochondria", 2021, Current Opinion in Chemical Biology
  • "Potent ClpP agonists with anticancer properties bind with improved structural complementarity and alter the mitochondrial N-terminome", 2022, Structure

The scholar frequently collaborates with other researchers. Their most common co-authors are:

  • Mark Mabanglo
  • Marim Barghash
  • Thiago Vargas Seraphim
  • Emily Majaesic
  • Jeffrey Lynham

Walid A. Houry's publications appear in various venues. Some of the most frequent include:

  • OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)
  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
  • Journal of Biological Chemistry
  • Structure
  • Nature Communications

Best Publications

  • The genetic landscape of a cell.

    Michael Costanzo;Anastasia Baryshnikova;Jeremy Bellay;Yungil Kim

  • Navigating the Chaperone Network: An Integrative Map of Physical and Genetic Interactions Mediated by the Hsp90 Chaperone

    Rongmin Zhao;Mike Davey;Ya-Chieh Hsu;Pia Kaplanek

  • Identification of in vivo substrates of the chaperonin GroEL.

    Houry Wa;Frishman D;Eckerskorn C;Lottspeich F

  • Polypeptide flux through bacterial Hsp70: DnaK cooperates with trigger factor in chaperoning nascent chains.

    S. A. Teter;W. A. Houry;D. Ang;T. Tradler

  • In Vivo Observation of Polypeptide Flux through the Bacterial Chaperonin System

    Karla L Ewalt;Joseph P Hendrick;Walid A Houry;Walid A Houry;F.Ulrich Hartl;F.Ulrich Hartl

  • The AAA+ superfamily of functionally diverse proteins

    Jamie D. Snider;Guillaume Thibault;Walid A Houry

  • Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality

    Jo Ishizawa;Sarah F. Zarabi;Sarah F. Zarabi;R. Eric Davis;Ondrej Halgas;Ondrej Halgas

  • Inhibition of the Mitochondrial Protease ClpP as a Therapeutic Strategy for Human Acute Myeloid Leukemia

    Alicia Cole;Zezhou Wang;Etienne Coyaud;Veronique Voisin

  • Mechanisms of Acid Resistance in Escherichia coli

    Usheer Kanjee;Walid A Houry

  • An atlas of chaperone–protein interactions in Saccharomyces cerevisiae: implications to protein folding pathways in the cell

    Yunchen Gong;Yoshito Kakihara;Nevan Krogan;Jack Greenblatt

  • ClpP: A distinctive family of cylindrical energy-dependent serine proteases

    Angela Yeou Hsiung Yu;Walid A. Houry

  • Quantitative NMR spectroscopy of supramolecular complexes: Dynamic side pores in ClpP are important for product release

    Remco Sprangers;Anna Gribun;Peter M. Hwang;Walid A. Houry

  • Molecular chaperone Hsp90 stabilizes Pih1/Nop17 to maintain R2TP complex activity that regulates snoRNA accumulation

    Rongmin Zhao;Yoshito Kakihara;Anna Gribun;Jennifer Huen

  • The role of Hsp90 in protein complex assembly

    Taras Makhnevych;Walid A. Houry

  • Direct binding targets of the stringent response alarmone (p)ppGpp

    Usheer Kanjee;Koji Ogata;Walid A. Houry

  • Chaperone-assisted protein folding in the cell cytoplasm.

    Walid A. Houry

  • Hsp90: a chaperone for protein folding and gene regulation.

    Rongmin Zhao;Walid A Houry

  • The ClpP Double Ring Tetradecameric Protease Exhibits Plastic Ring-Ring Interactions, and the N Termini of Its Subunits Form Flexible Loops That Are Essential for ClpXP and ClpAP Complex Formation

    Anna Gribun;Matthew S. Kimber;Reagan Ching;Remco Sprangers

  • AAA+ proteins: diversity in function, similarity in structure.

    Jamie Snider;Walid A. Houry

  • The R2TP complex: discovery and functions.

    Yoshito Kakihara;Walid A. Houry

Frequent Co-Authors

Robert A. Batey
Robert A. Batey University of Toronto
Emil F. Pai
Emil F. Pai University of Toronto
Lewis E. Kay
Lewis E. Kay University of Toronto
Aaron D. Schimmer
Aaron D. Schimmer Princess Margaret Cancer Centre
Harold A. Scheraga
Harold A. Scheraga Cornell University
Jack Greenblatt
Jack Greenblatt University of Toronto
Andrew Emili
Andrew Emili Boston University
Scott D. Gray-Owen
Scott D. Gray-Owen University of Toronto
John L. Rubinstein
John L. Rubinstein University of Toronto
Charles Boone
Charles Boone University of Toronto

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