World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
59
Citations
11117
World Ranking
12678
National Ranking
904

Overview

Stephan A. Sieber is affiliated with the Technical University of Munich in Germany and has contributed extensively to research in biochemistry, genetics, and molecular biology. Their work integrates multiple subfields, including molecular biology, materials chemistry, organic chemistry, cell biology, and pharmacology.

The scientist's research focuses on several main topics:

  • Microbial Natural Products and Biosynthesis
  • Computational Drug Discovery Methods
  • Biochemical and Molecular Research
  • Peptidase Inhibition and Analysis
  • Click Chemistry and Applications
  • Antibiotic Resistance in Bacteria
  • Advanced biosensing and bioanalysis techniques

Sieber's recent publications span a range of subjects and journals, illustrating a broad multidisciplinary approach. Examples include:

  • Practical guidelines for the use of gradient boosting for molecular property prediction, 2023, Journal of Cheminformatics
  • Electrophilic reactivities of cyclic enones and α,β-unsaturated lactones, 2021, Chemical Science
  • Covalent Mucin Coatings Form Stable Anti-Biofouling Layers on a Broad Range of Medical Polymer Materials, 2020, Advanced Materials Interfaces
  • FICD activity and AMPylation remodelling modulate human neurogenesis, 2020, Nature Communications
  • Extracellular LGALS3BP regulates neural progenitor position and relates to human cortical complexity, 2021, Nature Communications

The venues in which the scientist frequently publishes include the following:

  • Angewandte Chemie International Edition
  • Angewandte Chemie
  • The Cambridge Structural Database
  • Chemical Science
  • bioRxiv (Cold Spring Harbor Laboratory)

Collaborations have been a consistent part of their work, with frequent co-authors including:

  • Nina C. Bach
  • Dietrich Mostert
  • Davide Boldini
  • Patrick W. A. Allihn
  • Pavel Kielkowski

The scientist's publication record features research that intersects advanced chemistry methods, molecular mechanisms in biology, and approaches for improving medicinal and material sciences. Their activity in both experimental and computational methodologies supports ongoing developments across several scientific disciplines.

Best Publications

  • Molecular mechanisms underlying nonribosomal peptide synthesis: approaches to new antibiotics.

    Stephan A Sieber;Mohamed A Marahiel

  • The microstructure and micromechanics of the tendon-bone insertion

    L. Rossetti;L. A. Kuntz;E. Kunold;J. Schock

  • Chemical proteomics approaches for identifying the cellular targets of natural products

    M. H. Wright;S. A. Sieber

  • Proteomic profiling of metalloprotease activities with cocktails of active-site probes

    Stephan A Sieber;Sherry Niessen;Heather S Hoover;Benjamin F Cravatt

  • Electrophilic natural products and their biological targets

    Malte Gersch;Johannes Kreuzer;Stephan A. Sieber

  • Helicobacter pylori adhesin HopQ engages in a virulence-enhancing interaction with human CEACAMs

    Anahita Javaheri;Tobias Kruse;Kristof Moonens;Raquel Mejías-Luque

  • Beta-lactones as specific inhibitors of ClpP attenuate the production of extracellular virulence factors of Staphylococcus aureus.

    Thomas Böttcher;Stephan A. Sieber

  • Natural Products and Their Biological Targets: Proteomic and Metabolomic Labeling Strategies

    Thomas Böttcher;Maximilian Pitscheider;Stephan A. Sieber

  • Learning from Nature's Drug Factories: Nonribosomal Synthesis of Macrocyclic Peptides

    Stephan A. Sieber;Mohamed A. Marahiel

  • β-Lactones as Privileged Structures for the Active-Site Labeling of Versatile Bacterial Enzyme Classes

    Thomas Böttcher;Stephan A. Sieber

  • Thinking Outside the Box-Novel Antibacterials To Tackle the Resistance Crisis.

    Markus Lakemeyer;Weining Zhao;Franziska A. Mandl;Peter Hammann

  • Synthesis and Derivatization of Daptomycin: A Chemoenzymatic Route to Acidic Lipopeptide Antibiotics

    Jan Grünewald;Stephan A Sieber;Christoph Mahlert;Uwe Linne

  • Characterization of the surfactin synthetase C-terminal thioesterase domain as a cyclic depsipeptide synthase.

    Claire C Tseng;Steven D Bruner;Rahul M Kohli;Mohamed A Marahiel

  • Beta-lactams as selective chemical probes for the in vivo labeling of bacterial enzymes involved in cell wall biosynthesis, antibiotic resistance, and virulence.

    Isabell Staub;Stephan A Sieber

  • Repurposing human kinase inhibitors to create an antibiotic active against drug-resistant Staphylococcus aureus, persisters and biofilms.

    Philipp Le;Elena Kunold;Elena Kunold;Robert Macsics;Katharina Rox

  • Identification of Acyl Protein Thioesterases 1 and 2 as the Cellular Targets of the Ras-Signaling Modulators Palmostatin B and M

    Marion Rusch;Tobias J. Zimmermann;Marco Bürger;Frank J. Dekker

  • AAA+ chaperones and acyldepsipeptides activate the ClpP protease via conformational control

    Malte Gersch;Kirsten Famulla;Maria Dahmen;Christoph Göbl

  • Chirality of peptide bond-forming condensation domains in nonribosomal peptide synthetases: the C5 domain of tyrocidine synthetase is a (D)C(L) catalyst.

    Susan L Clugston;Stephan A Sieber;Mohamed A Marahiel;Christopher T Walsh

  • Unraveling the protein targets of vancomycin in living S. aureus and E. faecalis cells.

    Jürgen Eirich;Ronald Orth;Stephan A Sieber

  • Electron-Beam Induced Growth of Bare Silver Nanowires from Zeolite Crystallites

    M. J. Edmondson;W. Zhou;S. A. Sieber;S. A. Sieber;I. P. Jones

Frequent Co-Authors

Mohamed A. Marahiel
Mohamed A. Marahiel Philipp University of Marburg
Michael Groll
Michael Groll Technical University of Munich
Uli Kazmaier
Uli Kazmaier Saarland University
Herbert Waldmann
Herbert Waldmann Max Planck Society
Kirsten Jung
Kirsten Jung Ludwig-Maximilians-Universität München
Angelika M. Vollmar
Angelika M. Vollmar Ludwig-Maximilians-Universität München
Christopher T. Walsh
Christopher T. Walsh Stanford University
Benjamin F. Cravatt
Benjamin F. Cravatt Scripps Research Institute
Fritz E. Kühn
Fritz E. Kühn Technical University of Munich
Eva Medina
Eva Medina Helmholtz Centre for Infection Research

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Studying Biology and Biochemistry in the USA opens up a wide array of rewarding career paths. Many students leverage this academic background to pursue further education in allied health fields through flexible online programs.

For those interested in human health, movement, and performance, fitness degrees online and online kinesiology programs are popular choices. These degrees can prepare graduates for careers in sports medicine, rehabilitation, fitness training, and wellness coaching.

Biology and Biochemistry graduates seeking to specialize in advanced nursing can explore fastest post master's pmhnp programs, which lead to roles in psychiatric-mental health. Additionally, post masters fnp programs are available for those wanting to become family nurse practitioners.

With the increasing availability and flexibility of online degrees, transitioning from a background in Biology or Biochemistry into specialized healthcare or fitness professions is more accessible than ever.

Best Scientists Citing Stephan A. Sieber

Trending Scientists

Recently Published Articles