World's Best Scientists 2026 revealed!

D-Index & Metrics

Chemistry

D-Index
76
Citations
21568
World Ranking
4224
National Ranking
315

Biology and Biochemistry

D-Index
77
Citations
21792
World Ranking
4773
National Ranking
350

Overview

Michael Groll is affiliated with the Technical University of Munich in Germany and is active in the fields of biochemistry, genetics, and molecular biology, with significant contributions to medicine. Their research encompasses several subfields including molecular biology, pharmacology, oncology, materials chemistry, and organic chemistry.

Their work covers multiple main topics such as peptidase inhibition and analysis, microbial natural products and biosynthesis, ubiquitin and proteasome pathways, plant biochemistry and biosynthesis, glycosylation and glycoproteins research, entomopathogenic microorganisms in pest control, and genomics and phylogenetic studies.

Michael Groll has contributed to numerous publications, with frequent appearances in high-profile journals and venues. These include:

  • Angewandte Chemie International Edition
  • Angewandte Chemie
  • Structure
  • Nature Chemistry
  • bioRxiv (Cold Spring Harbor Laboratory)

Recent notable papers by Groll cover diverse biochemical and structural topics:

  • "Global analysis of biosynthetic gene clusters reveals conserved and unique natural products in entomopathogenic nematode-symbiotic bacteria," 2022, Nature Chemistry
  • "Evolution-inspired engineering of nonribosomal peptide synthetases," 2024, Science
  • "Fatal amyloid formation in a patient's antibody light chain is caused by a single point mutation," 2020, eLife
  • "Structural snapshots of the minimal PKS system responsible for octaketide biosynthesis," 2020, Nature Chemistry
  • "A monodomain class II terpene cyclase assembles complex isoprenoid scaffolds," 2020, Nature Chemistry

The scientist collaborates regularly with several co-authors, including:

  • Helge B. Bode (18 joint publications)
  • Wolfgang Kuttenlochner (16 joint publications)
  • E.M. Huber (15 joint publications)
  • Ville R. I. Kaila (7 joint publications)
  • F. Ecker (7 joint publications)

Best Publications

  • Structure of 20S proteasome from yeast at 2.4 A resolution.

    Michael Groll;Lars Ditzel;Jan Löwe;Daniela Stock

  • A gated channel into the proteasome core particle.

    Michael Groll;Monica Bajorek;Alwin Köhler;Luis Moroder

  • Crystal Structure of the Boronic Acid-Based Proteasome Inhibitor Bortezomib in Complex with the Yeast 20S Proteasome

    Michael Groll;Celia R. Berkers;Hidde L. Ploegh;Huib Ovaa

  • Immuno- and constitutive proteasome crystal structures reveal differences in substrate and inhibitor specificity.

    Eva M. Huber;Michael Basler;Ricarda Schwab;Wolfgang Heinemeyer

  • 20S proteasome and its inhibitors: crystallographic knowledge for drug development.

    Ljudmila Borissenko;Michael Groll

  • Cleavage motifs of the yeast 20S proteasome β subunits deduced from digests of enolase 1

    Alexander K. Nussbaum;Tobias P. Dick;Wieland Keilholz;Markus Schirle

  • Crystal structures of Salinosporamide A (NPI-0052) and B (NPI-0047) in complex with the 20S proteasome reveal important consequences of beta-lactone ring opening and a mechanism for irreversible binding.

    Michael Groll;Robert Huber;Barbara C. M. Potts

  • Ubiquitin docking at the proteasome through a novel pleckstrin-homology domain interaction

    Patrick Schreiner;Xiang Chen;Koraljka Husnjak;Leah Randles

  • The catalytic sites of 20S proteasomes and their role in subunit maturation: A mutational and crystallographic study

    Michael Groll;Wolfgang Heinemeyer;Sibylle Jäger;Tobias Ullrich

  • Crystal Structure of Epoxomicin:20S Proteasome reveals a molecular basis for selectivity of alpha,beta-Epoxyketone Proteasome Inhibitors

    Michael Groll;Kyung Bo Kim;Norman Kairies;Robert Huber

  • Contribution of Proteasomal β-Subunits to the Cleavage of Peptide Substrates Analyzed with Yeast Mutants

    Tobias P. Dick;Alexander K. Nussbaum;Martin Deeg;Wolfgang Heinemeyer

  • A plant pathogen virulence factor inhibits the eukaryotic proteasome by a novel mechanism

    Michael Groll;Barbara Schellenberg;André S. Bachmann;Crystal R. Archer

  • Substrate access and processing by the 20S proteasome core particle.

    Michael Groll;Robert Huber

  • Molecular Machines for Protein Degradation

    Michael Groll;Matthias Bochtler;Hans Brandstetter;Tim Clausen

  • Marizomib, a Proteasome Inhibitor for All Seasons: Preclinical Profile and a Framework for Clinical Trials

    B. C. Potts;M. X. Albitar;K. C. Anderson;S. Baritaki

  • The 26S proteasome: assembly and function of a destructive machine

    Nerea Gallastegui;Michael Groll

  • Mechanism and Regulation of DNA-Protein Crosslink Repair by the DNA-Dependent Metalloprotease SPRTN

    Julian Stingele;Roberto Bellelli;Ferdinand Alte;Graeme Hewitt

  • Inhibitors of the eukaryotic 20S proteasome core particle: a structural approach

    Michael Groll;Robert Huber

  • The architecture of functional modules in the Hsp90 co-chaperone Sti1/Hop.

    Andreas B Schmid;Stephan Lagleder;Stephan Lagleder;Melissa Ann Gräwert;Alina Röhl

  • Induced‐Fit Mechanism in Class I Terpene Cyclases

    Philipp Baer;Patrick Rabe;Patrick Rabe;Katrin Fischer;Christian A. Citron;Christian A. Citron

  • Crystal structure of the 20 S proteasome:TMC-95A complex: a non-covalent proteasome inhibitor.

    Michael Groll;Yutaka Koguchi;Robert Huber;Jun Kohno

  • Crystal structure of heat shock locus V (HslV) from Escherichia coli.

    Matthias Bochtler;Lars Ditzel;Michael Groll;Robert Huber

Frequent Co-Authors

Robert Huber
Robert Huber University of Duisburg-Essen
Wolfgang Eisenreich
Wolfgang Eisenreich Technical University of Munich
Markus Kaiser
Markus Kaiser University of Duisburg-Essen
Luis Moroder
Luis Moroder Max Planck Society
Christian Hertweck
Christian Hertweck Friedrich Schiller University Jena
Stephan A. Sieber
Stephan A. Sieber Technical University of Munich
Axel A. Brakhage
Axel A. Brakhage Leibniz Association
Robert Huber
Robert Huber Agricultural & Applied Economics Association
Adelbert Bacher
Adelbert Bacher Technical University of Munich
Christoph Driessen
Christoph Driessen University of St. Gallen

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Studying Chemistry in the USA opens various career pathways, many of which integrate directly with related fields in health and forensic sciences. For those interested in healthcare, understanding how much schooling to be a pharmacist is crucial, as becoming a pharmacist typically requires extensive education beyond a chemistry degree. This can guide decisions on further study and professional development.

In the forensic sciences, chemistry skills are highly valuable, especially for roles like autopsy technicians. When considering this path, exploring the autopsy tech salary and job outlook helps students understand the financial and practical benefits of pursuing this career.

For students seeking flexibility, enrolling in online forensic science courses offers a valuable way to build relevant expertise from anywhere. These programs often complement a chemistry background and prepare graduates for diverse forensic roles.

Additionally, advancing your education with an online master's degree in forensic psychology can enhance your understanding of the psychological aspects related to crime investigations, creating interdisciplinary career opportunities that combine chemistry and behavioral science.

Best Scientists Citing Michael Groll

Trending Scientists