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Christopher J. Kirk

Christopher J. Kirk

D-Index & Metrics

Biology and Biochemistry

D-Index
65
Citations
15915
World Ranking
9117
National Ranking
4049

Overview

Christopher J. Kirk is affiliated with Kezar Life Sciences in the United States and has contributed extensively to research in medicine and biochemistry, genetics, and molecular biology. The main subfields of their work include molecular biology, immunology, oncology, radiology, nuclear medicine and imaging, and genetics.

The primary research topics covered by this scientist encompass:

  • Ubiquitin and proteasome pathways
  • Peptidase inhibition and analysis
  • Monoclonal and polyclonal antibodies research
  • Systemic lupus erythematosus research
  • Immune cell function and interaction
  • Glycosylation and glycoproteins research
  • Adenosine and purinergic signaling

Christopher J. Kirk has published papers in several scientific venues, with frequent publications in:

  • Annals of the Rheumatic Diseases
  • Regular and Young Investigator Award Abstracts
  • Cancer Research
  • Nature Chemical Biology
  • European Journal of Immunology

Recent publications authored or co-authored by Christopher J. Kirk include:

  • Discovery and Early Clinical Development of Selective Immunoproteasome Inhibitors (2021), published in Cells
  • Proteasome Inhibitors and Their Pharmacokinetics, Pharmacodynamics, and Metabolism (2021), published in International Journal of Molecular Sciences
  • Signal peptide mimicry primes Sec61 for client-selective inhibition (2023), published in Nature Chemical Biology
  • Zetomipzomib (KZR-616) attenuates lupus in mice via modulation of innate and adaptive immune responses (2023), published in Frontiers in Immunology
  • Effective therapy of polymyositis in mice via selective inhibition of the immunoproteasome (2022), published in European Journal of Immunology

The research collaborations of Christopher J. Kirk include frequent co-authors such as:

  • Tony Muchamuel
  • Janet L. Anderl
  • Dustin L. McMinn
  • Eric Lowe
  • Henry W. B. Johnson

Best Publications

  • Antitumor Activity of PR-171, a Novel Irreversible Inhibitor of the Proteasome

    Susan D. Demo;Christopher J. Kirk;Monette A. Aujay;Tonia J. Buchholz

  • A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis

    Tony Muchamuel;Michael Basler;Monette A Aujay;Erika Suzuki

  • Rapid breakdown of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate in rat hepatocytes stimulated by vasopressin and other Ca2+-mobilizing hormones.

    J A Creba;C P Downes;P T Hawkins;G Brewster

  • The stimulation of inositol lipid metabolism that accompanies calcium mobilization in stimulated cells: defined characteristics and unanswered questions.

    Robert Hall Michell;C. J. Kirk;Lynne M. Jones;C. P. Downes

  • Immuno- and constitutive proteasome crystal structures reveal differences in substrate and inhibitor specificity.

    Eva M. Huber;Michael Basler;Ricarda Schwab;Wolfgang Heinemeyer

  • Hormonal stimulation of phosphatidylinositol breakdown with particular reference to the hepatic effects of vasopressin.

    R. H. Michell;C. J. Kirk;M. M. Billah

  • Nonproteasomal targets of the proteasome inhibitors bortezomib and carfilzomib: a link to clinical adverse events.

    Shirin Arastu-Kapur;Janet L. Anderl;Marianne Kraus;Francesco Parlati

  • Proteasomes in immune cells: more than peptide producers?

    Marcus Groettrup;Christopher J. Kirk;Michael Basler

  • Design and Synthesis of an Orally Bioavailable and Selective Peptide Epoxyketone Proteasome Inhibitor (PR-047)

    Han-Jie Zhou;Monette A Aujay;Mark K Bennett;Maya Dajee

  • Stepwise enzymatic dephosphorylation of inositol 1,4,5-trisphosphate to inositol in liver

    Diane J. Storey;Stephen B. Shears;Christopher J. Kirk;Robert H. Michell

  • The immunoproteasome in antigen processing and other immunological functions.

    Michael Basler;Christopher J Kirk;Marcus Groettrup

  • Prevention of experimental colitis by a selective inhibitor of the immunoproteasome.

    Michael Basler;Maya Dajee;Carlo Moll;Marcus Groettrup

  • A novel orally active proteasome inhibitor ONX 0912 triggers in vitro and in vivo cytotoxicity in multiple myeloma

    Dharminder Chauhan;Ajita V. Singh;Monette Aujay;Christopher J. Kirk

  • Rapid accumulation of inositol phosphates in isolated rat superior cervical sympathetic ganglia exposed to V1-vasopressin and muscarinic cholinergic stimuli.

    E A Bone;P Fretten;S Palmer;C J Kirk

  • Hormone-stimulated metabolism of inositol lipids and its relationship to hepatic receptor function.

    Kirk Cj;Creba Ja;Downes Cp;Michell Rh

  • Review: Gene-Modified Dendritic Cells for Use in Tumor Vaccines

    Christopher J. Kirk;James J. Mulé

  • Beneficial effect of novel proteasome inhibitors in murine lupus via dual inhibition of type I interferon and autoantibody-secreting cells.

    H. Travis Ichikawa;Thomas Conley;Tony Muchamuel;Jing Jiang

  • T Cell-dependent Antitumor Immunity Mediated by Secondary Lymphoid Tissue Chemokine: Augmentation of Dendritic Cell-based Immunotherapy

    Christopher J. Kirk;Dennis Hartigan-O’Connor;Brian J. Nickoloff;Jeffrey S. Chamberlain

  • Impaired bortezomib binding to mutant beta 5 subunit of the proteasome is the underlying basis for bortezomib resistance in leukemia cells.

    N E Franke;D Niewerth;Y G Assaraf;J van Meerloo

  • Inhibition of the immunoproteasome ameliorates experimental autoimmune encephalomyelitis.

    Michael Basler;Sarah Mundt;Tony Muchamuel;Carlo Moll

Frequent Co-Authors

Robert H. Michell
Robert H. Michell University of Birmingham
Stephen B. Shears
Stephen B. Shears National Institutes of Health
Yehuda G. Assaraf
Yehuda G. Assaraf Technion – Israel Institute of Technology
Gerrit Jansen
Gerrit Jansen Amsterdam UMC
Sonja Zweegman
Sonja Zweegman Amsterdam UMC
Marcus Groettrup
Marcus Groettrup University of Konstanz
Phillip T. Hawkins
Phillip T. Hawkins Babraham Institute
Noopur Raje
Noopur Raje Harvard University
Ravi Vij
Ravi Vij Washington University in St. Louis

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