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Christopher J. Kirk

Christopher J. Kirk

Kezar Life Sciences
United States

D-Index & Metrics

Biology and Biochemistry

D-Index
65
Citations
15915
World Ranking
9117
National Ranking
4049

Christopher J. Kirk publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Christopher J. Kirk sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 231 publications — 61st percentile

61% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

Christopher J. Kirk D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Christopher J. Kirk sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 65 D-Index — 55th percentile

55% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Overview

Christopher J. Kirk is affiliated with Kezar Life Sciences in the United States and has contributed extensively to research in medicine and biochemistry, genetics, and molecular biology. The main subfields of their work include molecular biology, immunology, oncology, radiology, nuclear medicine and imaging, and genetics.

The primary research topics covered by this scientist encompass:

  • Ubiquitin and proteasome pathways
  • Peptidase inhibition and analysis
  • Monoclonal and polyclonal antibodies research
  • Systemic lupus erythematosus research
  • Immune cell function and interaction
  • Glycosylation and glycoproteins research
  • Adenosine and purinergic signaling

Christopher J. Kirk has published papers in several scientific venues, with frequent publications in:

  • Annals of the Rheumatic Diseases
  • Regular and Young Investigator Award Abstracts
  • Cancer Research
  • Nature Chemical Biology
  • European Journal of Immunology

Recent publications authored or co-authored by Christopher J. Kirk include:

  • Discovery and Early Clinical Development of Selective Immunoproteasome Inhibitors (2021), published in Cells
  • Proteasome Inhibitors and Their Pharmacokinetics, Pharmacodynamics, and Metabolism (2021), published in International Journal of Molecular Sciences
  • Signal peptide mimicry primes Sec61 for client-selective inhibition (2023), published in Nature Chemical Biology
  • Zetomipzomib (KZR-616) attenuates lupus in mice via modulation of innate and adaptive immune responses (2023), published in Frontiers in Immunology
  • Effective therapy of polymyositis in mice via selective inhibition of the immunoproteasome (2022), published in European Journal of Immunology

The research collaborations of Christopher J. Kirk include frequent co-authors such as:

  • Tony Muchamuel
  • Janet L. Anderl
  • Dustin L. McMinn
  • Eric Lowe
  • Henry W. B. Johnson

Best Publications

  • Antitumor Activity of PR-171, a Novel Irreversible Inhibitor of the Proteasome

    Susan D. Demo;Christopher J. Kirk;Monette A. Aujay;Tonia J. Buchholz

  • A selective inhibitor of the immunoproteasome subunit LMP7 blocks cytokine production and attenuates progression of experimental arthritis

    Tony Muchamuel;Michael Basler;Monette A Aujay;Erika Suzuki

  • Rapid breakdown of phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate in rat hepatocytes stimulated by vasopressin and other Ca2+-mobilizing hormones.

    J A Creba;C P Downes;P T Hawkins;G Brewster

  • The stimulation of inositol lipid metabolism that accompanies calcium mobilization in stimulated cells: defined characteristics and unanswered questions.

    Robert Hall Michell;C. J. Kirk;Lynne M. Jones;C. P. Downes

  • Immuno- and constitutive proteasome crystal structures reveal differences in substrate and inhibitor specificity.

    Eva M. Huber;Michael Basler;Ricarda Schwab;Wolfgang Heinemeyer

  • Hormonal stimulation of phosphatidylinositol breakdown with particular reference to the hepatic effects of vasopressin.

    R. H. Michell;C. J. Kirk;M. M. Billah

  • Nonproteasomal targets of the proteasome inhibitors bortezomib and carfilzomib: a link to clinical adverse events.

    Shirin Arastu-Kapur;Janet L. Anderl;Marianne Kraus;Francesco Parlati

  • Proteasomes in immune cells: more than peptide producers?

    Marcus Groettrup;Christopher J. Kirk;Michael Basler

  • Design and Synthesis of an Orally Bioavailable and Selective Peptide Epoxyketone Proteasome Inhibitor (PR-047)

    Han-Jie Zhou;Monette A Aujay;Mark K Bennett;Maya Dajee

  • Stepwise enzymatic dephosphorylation of inositol 1,4,5-trisphosphate to inositol in liver

    Diane J. Storey;Stephen B. Shears;Christopher J. Kirk;Robert H. Michell

  • The immunoproteasome in antigen processing and other immunological functions.

    Michael Basler;Christopher J Kirk;Marcus Groettrup

  • Prevention of experimental colitis by a selective inhibitor of the immunoproteasome.

    Michael Basler;Maya Dajee;Carlo Moll;Marcus Groettrup

  • A novel orally active proteasome inhibitor ONX 0912 triggers in vitro and in vivo cytotoxicity in multiple myeloma

    Dharminder Chauhan;Ajita V. Singh;Monette Aujay;Christopher J. Kirk

  • Rapid accumulation of inositol phosphates in isolated rat superior cervical sympathetic ganglia exposed to V1-vasopressin and muscarinic cholinergic stimuli.

    E A Bone;P Fretten;S Palmer;C J Kirk

  • Hormone-stimulated metabolism of inositol lipids and its relationship to hepatic receptor function.

    Kirk Cj;Creba Ja;Downes Cp;Michell Rh

  • Review: Gene-Modified Dendritic Cells for Use in Tumor Vaccines

    Christopher J. Kirk;James J. Mulé

  • Beneficial effect of novel proteasome inhibitors in murine lupus via dual inhibition of type I interferon and autoantibody-secreting cells.

    H. Travis Ichikawa;Thomas Conley;Tony Muchamuel;Jing Jiang

  • T Cell-dependent Antitumor Immunity Mediated by Secondary Lymphoid Tissue Chemokine: Augmentation of Dendritic Cell-based Immunotherapy

    Christopher J. Kirk;Dennis Hartigan-O’Connor;Brian J. Nickoloff;Jeffrey S. Chamberlain

  • Impaired bortezomib binding to mutant beta 5 subunit of the proteasome is the underlying basis for bortezomib resistance in leukemia cells.

    N E Franke;D Niewerth;Y G Assaraf;J van Meerloo

  • Inhibition of the immunoproteasome ameliorates experimental autoimmune encephalomyelitis.

    Michael Basler;Sarah Mundt;Tony Muchamuel;Carlo Moll

Frequent Co-Authors

Robert H. Michell
Robert H. Michell University of Birmingham
Stephen B. Shears
Stephen B. Shears National Institutes of Health
Yehuda G. Assaraf
Yehuda G. Assaraf Technion – Israel Institute of Technology
Gerrit Jansen
Gerrit Jansen Amsterdam UMC
Sonja Zweegman
Sonja Zweegman Amsterdam UMC
Gertjan J. L. Kaspers
Gertjan J. L. Kaspers Amsterdam UMC
Marcus Groettrup
Marcus Groettrup University of Konstanz
Phillip T. Hawkins
Phillip T. Hawkins Babraham Institute
Noopur Raje
Noopur Raje Harvard University
Ravi Vij
Ravi Vij Washington University in St. Louis

External Links

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Best Scientists Citing Christopher J. Kirk

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Kenneth C. Anderson

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Herman S. Overkleeft

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Paul G. Richardson

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Harvard University

Publications: 33

Jeffrey S. Chamberlain

Jeffrey S. Chamberlain

University of Washington

Publications: 32

Robert Z. Orlowski

Robert Z. Orlowski

The University of Texas MD Anderson Cancer Center

Publications: 32

John H. Exton

John H. Exton

Vanderbilt University

Publications: 29

Michael J. Berridge

Michael J. Berridge

Babraham Institute

Publications: 28

Robert H. Michell

Robert H. Michell

University of Birmingham

Publications: 25

Tamas Balla

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National Institutes of Health

Publications: 25

John R. Williamson

John R. Williamson

University of Pennsylvania

Publications: 24

Gerrit Jansen

Gerrit Jansen

Amsterdam UMC

Publications: 24

James W. Putney

James W. Putney

National Institutes of Health

Publications: 24

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