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Immunology

D-Index
49
Citations
7275
World Ranking
4367
National Ranking
182

Overview

Jay C. Horvat is affiliated with the University of Newcastle Australia in Australia. Their research primarily focuses on the field of Medicine, with significant work in Immunology, Pulmonary and Respiratory Medicine, Physiology, Molecular Biology, and Surgery.

The main topics covered in their research include:

  • Asthma and respiratory diseases
  • Neonatal Respiratory Health Research
  • IL-33, ST2, and ILC Pathways
  • Chronic Obstructive Pulmonary Disease (COPD) Research
  • Iron Metabolism and Disorders
  • Eosinophilic Esophagitis
  • Pediatric health and respiratory diseases

Jay C. Horvat has contributed to several frequent publication venues including:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Journal of Allergy and Clinical Immunology
  • American Journal of Physiology-Lung Cellular and Molecular Physiology
  • Gastroenterology
  • Neuro-Oncology

The scientist has collaborated extensively with several co-authors, including:

  • Philip M. Hansbro (38 co-authored papers)
  • Richard Kim (22 co-authored papers)
  • Peter Wark (22 co-authored papers)
  • Chantal Donovan (20 co-authored papers)
  • Jemma Mayall (19 co-authored papers)

Among the notable papers featuring Jay C. Horvat's work are:

  • "Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages," 2022, Cell Metabolism
  • "Necroptosis Signaling Promotes Inflammation, Airway Remodeling, and Emphysema in Chronic Obstructive Pulmonary Disease," 2021, American Journal of Respiratory and Critical Care Medicine
  • "A microRNA-21-mediated SATB1/S100A9/NF-κB axis promotes chronic obstructive pulmonary disease pathogenesis," 2021, Science Translational Medicine
  • "Understanding the pathogenesis of occupational coal and silica dust-associated lung disease," 2022, European Respiratory Review
  • "Critical role for iron accumulation in the pathogenesis of fibrotic lung disease," 2020, The Journal of Pathology

Best Publications

  • Immunological decision-making: how does the immune system decide to mount a helper T-cell response?

    Gerard E. Kaiko;Jay C. Horvat;Kenneth W. Beagley;Philip M. Hansbro

  • Role for NLRP3 Inflammasome-mediated, IL-1β-Dependent Responses in Severe, Steroid-Resistant Asthma.

    Richard Y Kim;James W Pinkerton;Ama T Essilfie;Avril A B Robertson

  • Interferon-ε protects the female reproductive tract from viral and bacterial infection.

    Ka Yee Fung;Niamh E. Mangan;Helen Cumming;Jay C. Horvat

  • A new short-term mouse model of chronic obstructive pulmonary disease identifies a role for mast cell tryptase in pathogenesis

    Emma L. Beckett;Richard L. Stevens;Richard L. Stevens;Andrew G. Jarnicki;Richard Y. Kim

  • MicroRNA-21 drives severe, steroid-insensitive experimental asthma by amplifying phosphoinositide 3-kinase–mediated suppression of histone deacetylase 2

    Richard Y. Kim;Jay C. Horvat;James W. Pinkerton;Malcolm R. Starkey

  • Haemophilus influenzae infection drives IL-17-mediated neutrophilic allergic airways disease.

    Ama-Tawiah Essilfie;Jodie L. Simpson;Jodie L. Simpson;Jay C. Horvat;Julie A. Preston

  • Understanding the mechanisms of viral induced asthma: new therapeutic directions.

    Nicole G. Hansbro;Jay C. Horvat;Peter A. Wark;Peter A. Wark;Philip M. Hansbro

  • Necroptosis Signaling Promotes Inflammation, Airway Remodeling, and Emphysema in Chronic Obstructive Pulmonary Disease.

    Zhe Lu;Hannelore P Van Eeckhoutte;Gang Liu;Gang Liu;Prema M Nair

  • Fibulin-1 regulates the pathogenesis of tissue remodeling in respiratory diseases

    Gang Liu;Marion A. Cooley;Andrew G. Jarnicki;Alan C.-Y. Hsu

  • Neonatal Chlamydial Infection Induces Mixed T-Cell Responses That Drive Allergic Airway Disease

    Jay C. Horvat;Kenneth W. Beagley;Margaret A. Wade;Julie A. Preston

  • Inflammasomes in the lung

    James W. Pinkerton;Richard Y. Kim;Avril A.B. Robertson;Jeremy A. Hirota

  • Macrolide therapy suppresses key features of experimental steroid-sensitive and steroid-insensitive asthma

    Ama Tawiah Essilfie;Jay C. Horvat;Richard Y. Kim;Jemma R. Mayall

  • Role of atypical bacterial infection of the lung in predisposition/protection of asthma.

    Philip M. Hansbro;Kenneth W. Beagley;Jay C. Horvat;Peter G. Gibson

  • Evidence for Local and Systemic Immune Activation in Functional Dyspepsia and the Irritable Bowel Syndrome: A Systematic Review

    Grace Burns;Georgia Carroll;Andrea Mathe;Jay Horvat

  • Mechanisms and treatments for severe, steroid-resistant allergic airway disease and asthma

    Philip M. Hansbro;Richard Y. Kim;Malcolm R. Starkey;Chantal Donovan

  • Early-life chlamydial lung infection enhances allergic airways disease through age-dependent differences in immunopathology

    Jay C. Horvat;Malcolm R. Starkey;Richard Y. Kim;Simon Phipps

  • A microRNA-21-mediated SATB1/S100A9/NF-κB axis promotes chronic obstructive pulmonary disease pathogenesis

    Richard Y. Kim;Richard Y. Kim;Krishna P. Sunkara;Krishna P. Sunkara;Krishna P. Sunkara;Ken R. Bracke;Andrew G. Jarnicki

  • Saturated fatty acids, obesity, and the nucleotide oligomerization domain–like receptor protein 3 (NLRP3) inflammasome in asthmatic patients

    Lisa G. Wood;Qian Li;Hayley A. Scott;Sandra Rutting;Sandra Rutting

  • Inflammasomes in COPD and neutrophilic asthma.

    Richard Y Kim;James W Pinkerton;Peter G Gibson;Matthew A Cooper

  • Airway remodelling and inflammation in asthma are dependent on the extracellular matrix protein fibulin-1c

    Gang Liu;Marion A Cooley;Prema M Nair;Chantal Donovan

  • Chlamydial Respiratory Infection during Allergen Sensitization Drives Neutrophilic Allergic Airways Disease

    Jay C. Horvat;Malcolm R. Starkey;Richard Y. Kim;Kenneth W. Beagley;Kenneth W. Beagley

  • Streptococcus pneumoniae infection suppresses allergic airways disease by inducing regulatory T-cells

    Julie A Preston;Alison Nicole Thorburn;Malcolm R Starkey;Emma L Beckett

Frequent Co-Authors

Philip M. Hansbro
Philip M. Hansbro University of Technology Sydney
Paul S. Foster
Paul S. Foster Woolcock Institute of Medical Research
Peter G. Gibson
Peter G. Gibson University of Newcastle Australia
Peter A. B. Wark
Peter A. B. Wark University of Newcastle Australia
Kenneth W. Beagley
Kenneth W. Beagley Queensland University of Technology
Brian G. Oliver
Brian G. Oliver Woolcock Institute of Medical Research
Darryl A. Knight
Darryl A. Knight University of Newcastle Australia
Lisa Wood
Lisa Wood University of Newcastle Australia
Ian M. Adcock
Ian M. Adcock Imperial College London
Joerg Mattes
Joerg Mattes University of Newcastle Australia

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Related Online Degrees & Career Pathways

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Additionally, specialized online programs such as the best online PMHNP programs provide excellent clinical placement rates, crucial for gaining hands-on experience in psychiatric mental health nursing—a field connected to immune system health through the mind-body link.

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