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Immunology

D-Index
138
Citations
69228
World Ranking
174
National Ranking
18

Medicine

D-Index
140
Citations
71425
World Ranking
1700
National Ranking
174

Overview

Ian M. Adcock is affiliated with Imperial College London in the United Kingdom. Their research primarily focuses on the field of Medicine, with significant contributions in the subfields of Pulmonary and Respiratory Medicine, Physiology, Immunology, Infectious Diseases, and Molecular Biology.

The main topics covered in their work include:

  • Asthma and respiratory diseases
  • Chronic Obstructive Pulmonary Disease (COPD) Research
  • COVID-19 Clinical Research Studies
  • IL-33, ST2, and ILC Pathways
  • Respiratory and Cough-Related Research
  • SARS-CoV-2 and COVID-19 Research
  • Inhalation and Respiratory Drug Delivery

Among their recent papers are:

  • "Molecular mechanisms of oxidative stress in asthma," 2021, published in Molecular Aspects of Medicine
  • "The Immune Response and Immunopathology of COVID-19," 2020, published in Frontiers in Immunology
  • "Effect of mesenchymal stem cell-derived exosomes on the induction of mouse tolerogenic dendritic cells," 2020, published in Journal of Cellular Physiology
  • "Composite type-2 biomarker strategy versus a symptom-risk-based algorithm to adjust corticosteroid dose in patients with severe asthma: a multicentre, single-blind, parallel group, randomised controlled trial," 2020, published in The Lancet Respiratory Medicine
  • "Sputum microbiome profiles identify severe asthma phenotypes of relative stability at 12 to 18 months," 2020, published in Journal of Allergy and Clinical Immunology

Frequent co-authors include:

  • Kian Fan Chung (108 publications)
  • Nazanin Zounemat Kermani (59 publications)
  • Ratko Djukanović (43 publications)
  • Sharon Mumby (40 publications)
  • Esmaeil Mortaz (31 publications)

The most common publication venues where their work appears are:

  • Allergy (21 publications)
  • European Respiratory Journal (12 publications)
  • bioRxiv (Cold Spring Harbor Laboratory) (12 publications)
  • Journal of Allergy and Clinical Immunology (11 publications)
  • Research Square (Research Square) (11 publications)

Best Publications

  • International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma

    Kian Fan Chung;Sally E. Wenzel;Jan L. Brozek;Andrew Bush

  • Decreased histone deacetylase activity in chronic obstructive pulmonary disease.

    Kazuhiro Ito;Misako Ito;W Mark Elliott;Borja Cosio

  • Oxidative stress and redox regulation of lung inflammation in COPD

    Rahman I;Adcock Im

  • Glucocorticoid resistance in inflammatory diseases

    Peter J Barnes;Ian M Adcock

  • Anti-inflammatory actions of steroids: molecular mechanisms

    Peter J. Barnes;Ian Adcock

  • Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits interleukin-1beta-induced histone H4 acetylation on lysines 8 and 12.

    Kazuhiro Ito;Peter J. Barnes;Ian M. Adcock

  • Multifaceted mechanisms in COPD: inflammation, immunity, and tissue repair and destruction

    K. F. Chung;I. M. Adcock

  • Histone deacetylase 2–mediated deacetylation of the glucocorticoid receptor enables NF-κB suppression

    Kazuhiro Ito;Satoshi Yamamura;Sarah Essilfie-Quaye;Borja Cosio

  • Histone acetylation and deacetylation: importance in inflammatory lung diseases

    P J Barnes;I M Adcock;K Ito

  • Decreased histone deacetylase activity in chronic obstructive pulmonary disease: relationship to disease severity.

    K Ito;M Ito;Wm Elliott;M Cosio

  • A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression

    Kazuhiro Ito;Sam Lim;Gaetano Caramori;Borja Cosio

  • Cigarette smoking reduces histone deacetylase 2 expression, enhances cytokine expression, and inhibits glucocorticoid actions in alveolar macrophages.

    K. Ito;S. Lim;G. Caramori;K. F. Chung

  • Increased expression of nuclear factor-κB in bronchial biopsies from smokers and patients with COPD

    A Di Stefano;G Caramori;T Oates;A Capelli

  • Clinical and inflammatory characteristics of the European U-BIOPRED adult severe asthma cohort

    Dominick E. Shaw;Ana R. Sousa;Stephen J. Fowler;Louise J. Fleming

  • Theophylline restores histone deacetylase activity and steroid responses in COPD macrophages.

    Borja G. Cosio;Loukia Tsaprouni;Kazuhiro Ito;Elen Jazrawi

  • Management of severe asthma: a European Respiratory Society/American Thoracic Society guideline

    Fernando Holguin;Juan Carlos Cardet;Kian Fan Chung;Sarah Diver

  • Activation and localization of transcription factor, nuclear factor-kappaB, in asthma.

    Hart La;Krishnan Vl;Adcock Im;Barnes Pj

  • Trichostatin A is a histone deacetylase inhibitor with potent antitumor activity against breast cancer in vivo.

    D M Vigushin;S Ali;P E Pace;N Mirsaidi

  • Relationship between exhaled nitric oxide and mucosal eosinophilic inflammation in children with difficult asthma, after treatment with oral prednisolone.

    Donald N. R. Payne;Ian M. Adcock;Nicola M. Wilson;Tim Oates

  • p38 Mitogen-activated protein kinase–induced glucocorticoid receptor phosphorylation reduces its activity: Role in steroid-insensitive asthma

    Elvis Irusen;John G. Matthews;Atsushi Takahashi;Peter J. Barnes

  • Update on glucocorticoid action and resistance

    Kazuhiro Ito;K. Fian Chung;Ian M. Adcock

Frequent Co-Authors

Kian Fan Chung
Kian Fan Chung Imperial College London
Peter J. Barnes
Peter J. Barnes Imperial College London
Ratko Djukanovic
Ratko Djukanovic University of Southampton
Kazuhiro Ito
Kazuhiro Ito Imperial College London
Peter J. Sterk
Peter J. Sterk University of Amsterdam
Johan Garssen
Johan Garssen Utrecht University
Yike Guo
Yike Guo Hong Kong Baptist University
Alberto Papi
Alberto Papi University of Ferrara
Charles Auffray
Charles Auffray Centre national de la recherche scientifique, CNRS
Peter H. Howarth
Peter H. Howarth University of Southampton

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