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Medicine

D-Index
76
Citations
22270
World Ranking
18749
National Ranking
1696

Overview

Kazuhiro Ito is a researcher affiliated with Imperial College London in the United Kingdom. Their work primarily focuses on medicine, with a particular emphasis on pulmonary and respiratory medicine, epidemiology, physiology, immunology, and oncology.

The main topics covered in their research include:

  • Asthma and respiratory diseases
  • Antifungal resistance and susceptibility
  • Respiratory viral infections research
  • Inhalation and respiratory drug delivery
  • Respiratory and cough-related research
  • Cystic fibrosis research advances
  • Pediatric health and respiratory diseases

Among their frequent publication venues are:

  • Faculty Opinions - Post-Publication Peer Review of the Biomedical Literature
  • American Journal of Respiratory Cell and Molecular Biology
  • Scientific Reports
  • Journal of Clinical Medicine
  • Frontiers in Medicine

Their recent papers demonstrate a focus on respiratory infections and antifungal agents. Notable works include:

  • "Safety and nonclinical and clinical pharmacokinetics of PC945, a novel inhaled triazole antifungal agent" (2020, Pharmacology Research & Perspectives)
  • "Safety and Antiviral Effects of Nebulized PC786 in a Respiratory Syncytial Virus Challenge Study" (2020, The Journal of Infectious Diseases)
  • "PC945, a Novel Inhaled Antifungal Agent, for the Treatment of Respiratory Fungal Infections" (2020, Journal of Fungi)
  • "Cigarette smoke-induced impairment of autophagy in macrophages increases galectin-8 and inflammation" (2021, Scientific Reports)
  • "The role of antifungals in the management of patients with severe asthma" (2020, Clinical and Translational Allergy)

Their work has involved collaboration with several frequent coauthors, including:

  • Leah Daly
  • Jonathan Baker
  • Yasuo Kizawa
  • Pete Strong
  • Garth Rapeport

Kazuhiro Ito's research explores several aspects of respiratory health and disease, contributing to understanding pharmacokinetics, antiviral therapies, and the immunological impact of environmental factors such as cigarette smoke. Their publication record reflects active engagement in topics related to antifungal treatments and respiratory viral infections, advancing knowledge in inhaled drug delivery and respiratory disease management.

Best Publications

  • Decreased histone deacetylase activity in chronic obstructive pulmonary disease.

    Kazuhiro Ito;Misako Ito;W Mark Elliott;Borja Cosio

  • Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits interleukin-1beta-induced histone H4 acetylation on lysines 8 and 12.

    Kazuhiro Ito;Peter J. Barnes;Ian M. Adcock

  • Histone deacetylase 2–mediated deacetylation of the glucocorticoid receptor enables NF-κB suppression

    Kazuhiro Ito;Satoshi Yamamura;Sarah Essilfie-Quaye;Borja Cosio

  • COPD as a Disease of Accelerated Lung Aging

    Kazuhiro Ito;Peter J. Barnes

  • Histone acetylation and deacetylation: importance in inflammatory lung diseases

    P J Barnes;I M Adcock;K Ito

  • A molecular mechanism of action of theophylline: Induction of histone deacetylase activity to decrease inflammatory gene expression

    Kazuhiro Ito;Sam Lim;Gaetano Caramori;Borja Cosio

  • Cigarette smoking reduces histone deacetylase 2 expression, enhances cytokine expression, and inhibits glucocorticoid actions in alveolar macrophages.

    K. Ito;S. Lim;G. Caramori;K. F. Chung

  • Theophylline restores histone deacetylase activity and steroid responses in COPD macrophages.

    Borja G. Cosio;Loukia Tsaprouni;Kazuhiro Ito;Elen Jazrawi

  • Update on glucocorticoid action and resistance

    Kazuhiro Ito;K. Fian Chung;Ian M. Adcock

  • Corticosteroid resistance in chronic obstructive pulmonary disease: inactivation of histone deacetylase.

    Peter J Barnes;Kazuhiro Ito;Ian M Adcock

  • Oxidative stress reduces histone deacetylase 2 activity and enhances IL-8 gene expression: role of tyrosine nitration.

    K Ito;T Hanazawa;K Tomita;P.J Barnes

  • Anti-inflammatory Effects of Resveratrol in Lung Epithelial Cells: Molecular Mechanisms

    Louise E. Donnelly;Robert Newton;Gina E. Kennedy;Peter S. Fenwick

  • Targeting Phosphoinositide-3-Kinase-δ with Theophylline Reverses Corticosteroid Insensitivity in Chronic Obstructive Pulmonary Disease

    Yasuo To;Kazuhiro Ito;Yasuo Kizawa;Marco Failla

  • Expression and Activity of Histone Deacetylases in Human Asthmatic Airways

    Kazuhiro Ito;Gaetano Caramori;Sam Lim;Tim Oates

  • Effects of glucocorticoids on gene transcription.

    Ryuji Hayashi;Hiroo Wada;Kazuhiro Ito;Ian M. Adcock

  • Accelerated ageing of the lung in COPD: new concepts

    Nicolas Mercado;Kazuhiro Ito;Peter J Barnes

  • Inhibition of PI3Kdelta restores glucocorticoid function in smoking-induced airway inflammation in mice.

    John A. Marwick;Gaetano Caramori;Christopher S. Stevenson;Paolo Casolari

  • A protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9

    Yuji Nakamaru;Chaitanya Vuppusetty;Hiroo Wada;Jill C. Milne

  • Histone acetylase and deacetylase activity in alveolar macrophages and blood mononocytes in asthma.

    Borja G. Cosío;Buphinder Mann;Kazuhiro Ito;Elen Jazrawi

  • COPD as a disease of accelerated lung aging(a).

    Kazuhiro Ito;Peter J Barnes

Frequent Co-Authors

Peter J. Barnes
Peter J. Barnes Imperial College London
Ian M. Adcock
Ian M. Adcock Imperial College London
Alberto Papi
Alberto Papi University of Ferrara
Sebastian L. Johnston
Sebastian L. Johnston Imperial College London
Sergei A. Kharitonov
Sergei A. Kharitonov National Institutes of Health
Borja G. Cosío
Borja G. Cosío Instituto de Salud Carlos III
Kian Fan Chung
Kian Fan Chung Imperial College London
Patrick Mallia
Patrick Mallia Imperial College London
Alexandre Alanio
Alexandre Alanio Université Paris Cité
Stéphane Bretagne
Stéphane Bretagne Université Paris Cité

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