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Biology and Biochemistry

D-Index
47
Citations
10186
World Ranking
18621
National Ranking
1455

Overview

Patrick Mallia is affiliated with Imperial College London in the United Kingdom. Their research primarily focuses on medicine, with significant contributions in pulmonary and respiratory medicine, epidemiology, immunology, physiology, and infectious diseases. The main topics of their work include respiratory viral infections research, chronic obstructive pulmonary disease (COPD) research, asthma and respiratory diseases, COVID-19 clinical research studies, immune cell function and interaction, pediatric health and respiratory diseases, and IL-33, ST2, and ILC pathways.

Their recent publications cover a range of topics related to respiratory and immune function. Notable papers include:

  • Inhaled corticosteroids downregulate the SARS-CoV-2 receptor ACE2 in COPD through suppression of type I interferon, 2020, Journal of Allergy and Clinical Immunology
  • Airway mucins promote immunopathology in virus-exacerbated chronic obstructive pulmonary disease, 2022, Journal of Clinical Investigation
  • Experimental Antiviral Therapeutic Studies for Human Rhinovirus Infections, 2021, Journal of Experimental Pharmacology
  • Innate-like Gene Expression of Lung-Resident Memory CD8+ T Cells during Experimental Human Influenza: A Clinical Study, 2021, American Journal of Respiratory and Critical Care Medicine
  • Obesity dysregulates the pulmonary antiviral immune response, 2023, Nature Communications

Patrick Mallia's frequent co-authors include:

  • Sebastian L. Johnston
  • Aran Singanayagam
  • Onn Min Kon
  • Lydia Finney
  • Nicholas Glanville

They have published multiple works in several key venues, notably:

  • Journal of Allergy and Clinical Immunology
  • Nature Communications
  • American Journal of Respiratory and Critical Care Medicine
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Allergy

Their research spans clinical studies and experimental investigations, often focusing on mechanisms underlying respiratory diseases exacerbated by viral infections. Studies such as the downregulation of SARS-CoV-2 receptor ACE2 in COPD and investigations into airway mucins and immunopathology highlight a detailed examination of disease pathways and immune interactions.

Overall, Patrick Mallia's body of work contributes to a detailed understanding of respiratory viral infections, immune responses in chronic respiratory conditions, and the impact of factors such as obesity on pulmonary antiviral immunity.

Best Publications

  • Role of deficient type III interferon-λ production in asthma exacerbations

    Marco Contoli;Simon D Message;Vasile Laza-Stanca;Michael R Edwards

  • IL-33–Dependent Type 2 Inflammation during Rhinovirus-induced Asthma Exacerbations In Vivo

    David J. Jackson;David J. Jackson;Heidi Makrinioti;Batika M. J. Rana;Betty W. H. Shamji

  • The Role of Bacteria in the Pathogenesis and Progression of Idiopathic Pulmonary Fibrosis

    Phillip L. Molyneaux;Michael J. Cox;Saffron A. G. Willis-Owen;Patrick Mallia

  • Outgrowth of the Bacterial Airway Microbiome after Rhinovirus Exacerbation of Chronic Obstructive Pulmonary Disease

    Philip L. Molyneaux;Patrick Mallia;Michael J. Cox;Joseph Footitt

  • Asthma Exacerbations: Origin, Effect, and Prevention

    David J. Jackson;Annemarie Sykes;Patrick Mallia;Sebastian L. Johnston

  • Rhinovirus-induced lower respiratory illness is increased in asthma and related to virus load and Th1/2 cytokine and IL-10 production.

    Simon D. Message;Vasile Laza-Stanca;Patrick Mallia;Hayley L. Parker

  • Experimental Rhinovirus Infection as a Human Model of Chronic Obstructive Pulmonary Disease Exacerbation

    Patrick Mallia;Simon D. Message;Vera Gielen;Marco Contoli

  • RSV-specific airway resident memory CD8+ T cells and differential disease severity after experimental human infection

    Agnieszka Jozwik;Maximillian S. Habibi;Allan Paras;Jie Zhu

  • Rhinovirus Infection Induces Degradation of Antimicrobial Peptides and Secondary Bacterial Infection in Chronic Obstructive Pulmonary Disease

    Patrick Mallia;Joseph Footitt;Rosa Sotero;Annette Jepson

  • Rhinovirus 16–induced IFN-α and IFN-β are deficient in bronchoalveolar lavage cells in asthmatic patients

    Annemarie Sykes;Michael R. Edwards;Jonathan MacIntyre;Ajerico Del Rosario

  • How viral infections cause exacerbation of airway diseases.

    Patrick Mallia;Sebastian L. Johnston

  • Lung microbiology and exacerbations in COPD

    Victoria Beasley;Priya V Joshi;Aran Singanayagam;Philip L Molyneaux

  • The role of viral infections in exacerbations of chronic obstructive pulmonary disease and asthma.

    Richard Hewitt;Hugo Farne;Andrew Ritchie;Emma Luke

  • Mechanisms of virus‐induced asthma exacerbations: state‐of‐the‐art. A GA2LEN and InterAirways document

    N. G. Papadopoulos;P. Xepapadaki;P. Mallia;G. Brusselle

  • Corticosteroid suppression of antiviral immunity increases bacterial loads and mucus production in COPD exacerbations

    Aran Singanayagam;Nicholas Glanville;Jason L. Girkin;Yee Man Ching

  • Vitamin D increases the antiviral activity of bronchial epithelial cells in vitro

    Aurica G. Telcian;Mihnea T. Zdrenghea;Michael R. Edwards;Vasile Laza-Stanca

  • A Comprehensive Evaluation of Nasal and Bronchial Cytokines and Chemokines Following Experimental Rhinovirus Infection in Allergic Asthma: Increased Interferons (IFN-γ and IFN-λ) and Type 2 Inflammation (IL-5 and IL-13).

    Trevor T Hansel;Tanushree Tunstall;Maria-Belen Trujillo-Torralbo;Maria-Belen Trujillo-Torralbo;Betty Shamji

  • An experimental model of rhinovirus induced chronic obstructive pulmonary disease exacerbations: a pilot study

    Patrick Mallia;Simon D Message;Tatiana Kebadze;Hayley L Parker

  • The relevance of respiratory viral infections in the exacerbations of chronic obstructive pulmonary disease—A systematic review

    W.A.R. Zwaans;P. Mallia;M.E.C. van Winden;G.G.U. Rohde

  • Inhaled corticosteroids downregulate the SARS-CoV-2 receptor ACE2 in COPD through suppression of type I interferon

    Lydia J Finney;Nicholas Glanville;Hugo Farne;Julia Aniscenko

Frequent Co-Authors

Sebastian L. Johnston
Sebastian L. Johnston Imperial College London
Michael R. Edwards
Michael R. Edwards Imperial College London
Alberto Papi
Alberto Papi University of Ferrara
Nathan W. Bartlett
Nathan W. Bartlett Imperial College London
Jadwiga A. Wedzicha
Jadwiga A. Wedzicha Imperial College London
William O.C.M. Cookson
William O.C.M. Cookson Imperial College London
Miriam F. Moffatt
Miriam F. Moffatt Imperial College London
Ian M. Adcock
Ian M. Adcock Imperial College London
Peter J. Barnes
Peter J. Barnes Imperial College London
Kazuhiro Ito
Kazuhiro Ito Imperial College London

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