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Biology and Biochemistry

D-Index
70
Citations
14058
World Ranking
7166
National Ranking
253

Overview

Robert Newton is affiliated with the University of Calgary in Canada. Their research primarily spans the fields of Medicine as well as Biochemistry, Genetics and Molecular Biology. Within these broad areas, they have contributed substantially to subfields including Molecular Biology, Oncology, Cancer Research, Immunology, and Physiology.

The scientist's work covers several major research topics that include:

  • NF-κB Signaling Pathways
  • Immune Response and Inflammation
  • Asthma and respiratory diseases
  • Cytokine Signaling Pathways and Interactions
  • Receptor Mechanisms and Signaling
  • Fibroblast Growth Factor Research
  • Estrogen and related hormone effects

Recent publications authored or co-authored by Robert Newton include:

  • Clinicogenomic Analysis of FGFR2 -Rearranged Cholangiocarcinoma Identifies Correlates of Response and Mechanisms of Resistance to Pemigatinib, 2020, Cancer Discovery
  • Repression of transcription by the glucocorticoid receptor: A parsimonious model for the genomics era, 2021, Journal of Biological Chemistry
  • Parsaclisib Is a Next-Generation Phosphoinositide 3-Kinase δ Inhibitor with Reduced Hepatotoxicity and Potent Antitumor and Immunomodulatory Activities in Models of B-Cell Malignancy, 2020, Journal of Pharmacology and Experimental Therapeutics
  • Genomic determinants implicated in the glucocorticoid-mediated induction of KLF9 in pulmonary epithelial cells, 2020, Journal of Biological Chemistry
  • Preclinical characterization of itacitinib (INCB039110), a novel selective inhibitor of JAK1, for the treatment of inflammatory diseases, 2020, European Journal of Pharmacology

Frequent co-authors associated with Robert Newton include:

  • Mahmoud Mostafa
  • Akanksha Bansal
  • Anthony N. Gerber
  • Andrew Thorne
  • Richard Leigh

Publications by Robert Newton often appear in the following venues:

  • The FASEB Journal
  • Journal of Pharmacology and Experimental Therapeutics
  • Journal of Biological Chemistry
  • Molecular Pharmacology
  • PLoS ONE

Best Publications

  • Molecular mechanisms of glucocorticoid action: what is important?

    Robert Newton

  • Evidence for Involvement of NF-κB in the Transcriptional Control of COX-2 Gene Expression by IL-1β ☆

    Robert Newton;Lieske M.E. Kuitert;Martin Bergmann;Ian M. Adcock

  • Anti-inflammatory Effects of Resveratrol in Lung Epithelial Cells: Molecular Mechanisms

    Louise E. Donnelly;Robert Newton;Gina E. Kennedy;Peter S. Fenwick

  • Separating Transrepression and Transactivation: A Distressing Divorce for the Glucocorticoid Receptor?

    Robert Newton;Neil S Holden

  • Human labour is associated with nuclear factor-κB activity which mediates cyclo-oxygenase-2 expression and is involved with the ‘functional progesterone withdrawal’

    V.C. Allport;D. Pieber;D.M. Slater;R. Newton

  • IκBα Degradation and Nuclear Factor-κB DNA Binding Are Insufficient for Interleukin-1β and Tumor Necrosis Factor-α-induced κB-dependent Transcription REQUIREMENT FOR AN ADDITIONAL ACTIVATION PATHWAY

    Martin Bergmann;Lorraine Hart;Mark Lindsay;Peter J. Barnes

  • Identification of cyclic AMP phosphodiesterases 3, 4 and 7 in human CD4+ and CD8+ T-lymphocytes: role in regulating proliferation and the biosynthesis of interleukin-2.

    Mark A. Giembycz;Christopher J. Corrigan;Joachim Seybold;Robert Newton

  • TGFβ1 allele association with asthma severity

    Louise J. Pulleyn;Robert Newton;Ian M. Adcock;Peter J. Barnes

  • Identification of ADAM10 as a major source of HER2 ectodomain sheddase activity in HER2 overexpressing breast cancer cells.

    Phillip C.C. Liu;Xiangdong Liu;Yanlong Li;Maryanne Covington

  • Repression of Cyclooxygenase-2 and Prostaglandin E2Release by Dexamethasone Occurs by Transcriptional and Post-transcriptional Mechanisms Involving Loss of Polyadenylated mRNA

    Robert Newton;Joachim Seybold;Lieske M.E. Kuitert;Martin Bergmann

  • Differential IκB Kinase Activation and IκBα Degradation by Interleukin-1β and Tumor Necrosis Factor-α in Human U937 Monocytic Cells EVIDENCE FOR ADDITIONAL REGULATORY STEPS IN κB-DEPENDENT TRANSCRIPTION

    Yasuyuki Nasuhara;Ian M. Adcock;Matthew Catley;Peter J. Barnes

  • Discovery of BRL 50481 [3-(N,N-dimethylsulfonamido)-4-methyl-nitrobenzene], a Selective Inhibitor of Phosphodiesterase 7: In Vitro Studies in Human Monocytes, Lung Macrophages, and CD8+ T-Lymphocytes

    Susan J. Smith;Lenora B. Cieslinski;Robert Newton;Louise E. Donnelly

  • A Novel Kinase Inhibitor, INCB28060, Blocks c-MET–Dependent Signaling, Neoplastic Activities, and Cross-Talk with EGFR and HER-3

    Xiangdong Liu;Qian Wang;Gengjie Yang;Cindy Marando

  • Expression of cyclooxygenase types 1 and 2 in human fetal membranes at term

    Donna M. Slater;Louise C. Berger;Robert Newton;Gudrun E. Moore

  • Targeting the c-MET signaling pathway for cancer therapy

    Xiangdong Liu;Wenqing Yao;Robert C Newton;Peggy A Scherle

  • Long-acting beta2-adrenoceptor agonists synergistically enhance glucocorticoid-dependent transcription in human airway epithelial and smooth muscle cells.

    Manminder Kaur;Joanna E Chivers;Mark A Giembycz;Robert Newton

  • Beyond the dogma: novel beta2-adrenoceptor signalling in the airways.

    M. A. Giembycz;R. Newton

  • Photochemically enhanced binding of small molecules to the tumor necrosis factor receptor-1 inhibits the binding of TNF-alpha.

    Percy H. Carter;Peggy A. Scherle;Jodi A. Muckelbauer;Matthew E. Voss

  • Expression of RANTES mRNA and protein in airways of patients with mild asthma.

    N Berkman;V L Krishnan;T Gilbey;R Newton

  • Cytokine induction of cytosolic phospholipase A2 and cyclooxygenase-2 mRNA is suppressed by glucocorticoids in human epithelial cells.

    R. Newton;L.M. Kuitert;D.M. Slater;I.M. Adcock

Frequent Co-Authors

Mark A. Giembycz
Mark A. Giembycz University of Calgary
Peter J. Barnes
Peter J. Barnes Imperial College London
David Proud
David Proud University of Calgary
Ian M. Adcock
Ian M. Adcock Imperial College London
James M. Trzaskos
James M. Trzaskos Bristol-Myers Squibb (Germany)
Maria G. Belvisi
Maria G. Belvisi Imperial College London
David P. Siderovski
David P. Siderovski West Virginia University
Philip Stanier
Philip Stanier University College London
Mark A. Lindsay
Mark A. Lindsay University of Bath
Philippa C. Matthews
Philippa C. Matthews University of Oxford

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