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Mark A. Giembycz

Mark A. Giembycz

D-Index & Metrics

Biology and Biochemistry

D-Index
52
Citations
11168
World Ranking
16589
National Ranking
583

Overview

Mark A. Giembycz is affiliated with the University of Calgary in Canada. Their research primarily spans the disciplines of Biochemistry, Genetics and Molecular Biology, as well as Medicine, with a particular focus on Molecular Biology and Pharmacology. Their work also intersects with Physiology, Organic Chemistry, and Genetics.

The main research topics covered by their publications include:

  • Receptor Mechanisms and Signaling
  • Asthma and respiratory diseases
  • Inflammatory mediators and NSAID effects
  • Estrogen and related hormone effects
  • Eicosanoids and Hypertension Pharmacology
  • Phosphodiesterase function and regulation
  • Cholinesterase and Neurodegenerative Diseases

Frequent co-authors in their work include Omar Hamed, Radhika Joshi, Mahmoud Mostafa, Robert Newton, and Yan Dong.

Giembycz has published extensively in several scientific journals, with a notable number of contributions appearing in the following venues:

  • Journal of Pharmacology and Experimental Therapeutics
  • IUPHAR/BPS Guide to Pharmacology CITE
  • Molecular Pharmacology
  • The FASEB Journal
  • Pharmacological Reviews

Selected recent papers authored or co-authored by Giembycz include:

  • Prostanoid Receptors of the EP4-Subtype Mediate Gene Expression Changes in Human Airway Epithelial Cells with Potential Anti-Inflammatory Activity, 2020, Journal of Pharmacology and Experimental Therapeutics
  • β2-Adrenoceptor Agonists Promote Extracellular Signal-Regulated Kinase 1/2 Dephosphorylation in Human Airway Epithelial Cells by Canonical, cAMP-Driven Signaling Independently of β-Arrestin 2, 2021, Molecular Pharmacology
  • Transcriptome-Level Interactions between Budesonide and Formoterol Provide Insight into the Mechanism of Action of Inhaled Corticosteroid/Long-Acting β2-Adrenoceptor Agonist Combination Therapy in Asthma, 2020, Molecular Pharmacology
  • Cyclic nucleotide phosphodiesterases as drug targets, 2025, Pharmacological Reviews
  • Prostanoid receptors (version 2020.4) in the IUPHAR/BPS Guide to Pharmacology Database, 2020, IUPHAR/BPS Guide to Pharmacology CITE

Best Publications

  • Experimental design and analysis and their reporting II: updated and simplified guidance for authors and peer reviewers

    Michael J Curtis;Steve Alexander;Giuseppe Cirino;James R Docherty

  • Experimental design and analysis and their reporting: new guidance for publication in BJP.

    Michael J Curtis;Richard A Bond;Domenico Spina;Amrita Ahluwalia

  • Goals and practicalities of immunoblotting and immunohistochemistry: A guide for submission to the British Journal of Pharmacology.

    Steve P H Alexander;Richard E Roberts;Brad R S Broughton;Christopher G Sobey

  • Pharmacology of the Eosinophil

    Mark A. Giembycz;Mark A. Lindsay

  • Neutrophil Chemotactic Activity of Sputum From Patients With COPD: Role of Interleukin 8 and Leukotriene B4

    Kai M. Beeh;Oliver Kornmann;Roland Buhl;Sarah V. Culpitt

  • Delayed eosinophil apoptosis in asthma

    Hannu Kankaanranta;Mark A. Lindsay;Mark A. Giembycz;Xianzhi Zhang

  • Identification of cyclic AMP phosphodiesterases 3, 4 and 7 in human CD4+ and CD8+ T-lymphocytes: role in regulating proliferation and the biosynthesis of interleukin-2.

    Mark A. Giembycz;Christopher J. Corrigan;Joachim Seybold;Robert Newton

  • Differential regulation of cytokine release and leukocyte migration by lipopolysaccharide-stimulated primary human lung alveolar type II epithelial cells and macrophages.

    Andrew J. Thorley;Paul A. Ford;Mark A. Giembycz;Peter Goldstraw

  • Discovery of BRL 50481 [3-(N,N-dimethylsulfonamido)-4-methyl-nitrobenzene], a Selective Inhibitor of Phosphodiesterase 7: In Vitro Studies in Human Monocytes, Lung Macrophages, and CD8+ T-Lymphocytes

    Susan J. Smith;Lenora B. Cieslinski;Robert Newton;Louise E. Donnelly

  • Phosphodiesterase 4 inhibitors and the treatment of asthma: where are we now and where do we go from here?

    Mark A. Giembycz

  • Protein kinase C isoenzymes: a review of their structure, regulation and role in regulating airways smooth muscle tone and mitogenesis

    Benjamin L J Webb;Stuart J John Hirst;Mark A Giembycz

  • Prostanoid receptor antagonists: development strategies and therapeutic applications

    RL Jones;MA Giembycz;DF Woodward

  • Suppression of lipopolysaccharide-induced tumor necrosis factor-alpha generation from human peripheral blood monocytes by inhibitors of phosphodiesterase 4: interaction with stimulants of adenylyl cyclase.

    P. M. Seldon;P. J. Barnes;Koremu Meja;M. A. Giembycz

  • Long-acting beta2-adrenoceptor agonists synergistically enhance glucocorticoid-dependent transcription in human airway epithelial and smooth muscle cells.

    Manminder Kaur;Joanna E Chivers;Mark A Giembycz;Robert Newton

  • Beyond the dogma: novel beta2-adrenoceptor signalling in the airways.

    M. A. Giembycz;R. Newton

  • Cilomilast: a second generation phosphodiesterase 4 inhibitor for asthma and chronic obstructive pulmonary disease.

    Mark A Giembycz

  • Inhibition of eosinophil cyclic nucleotide PDE activity and opsonised zymosan-stimulated respiratory burst by 'type IV'-selective PDE inhibitors.

    Gordon Dent;Mark A. Giembycz;Klaus F. Rabe;Peter J. Barnes

  • Release of granulocyte-macrophage colony stimulating factor by human cultured airway smooth muscle cells : suppression by dexamethasone

    Michael A. Saunders;Jane A. Mitchell;Paul M. Seldon;Magdi H. Yacoub

  • Ubiquitous expression of phosphodiesterase 7A in human proinflammatory and immune cells.

    Susan J. Smith;Steven Brookes-Fazakerley;Louise E. Donnelly;Peter J. Barnes

  • A Holy Grail of asthma management: toward understanding how long‐acting β2‐adrenoceptor agonists enhance the clinical efficacy of inhaled corticosteroids

    M A Giembycz;M Kaur;R Leigh;R Newton

Frequent Co-Authors

Robert Newton
Robert Newton University of Calgary
Peter J. Barnes
Peter J. Barnes Imperial College London
Mark A. Lindsay
Mark A. Lindsay University of Bath
Maria G. Belvisi
Maria G. Belvisi Imperial College London
Hannu Kankaanranta
Hannu Kankaanranta University of Gothenburg
Eeva Moilanen
Eeva Moilanen Tampere University
Ian M. Adcock
Ian M. Adcock Imperial College London
David Proud
David Proud University of Calgary
Daniel Hoyer
Daniel Hoyer University of Melbourne
Paul G. Hellewell
Paul G. Hellewell Brunel University London

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