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Alfred L. Goldberg

Alfred L. Goldberg

Harvard University
United States

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Best Scientists
2025
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Biology and Biochemistry
USA
2023

D-Index & Metrics

Best Scientists

D-Index
189
Citations
128015
World Ranking
444
National Ranking
295

Biology and Biochemistry

D-Index
189
Citations
131053
World Ranking
48
National Ranking
41

Alfred L. Goldberg publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Alfred L. Goldberg sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 497 publications — 95th percentile

95% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

Alfred L. Goldberg D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Alfred L. Goldberg sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 189 D-Index — 100th percentile

100% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Research.com Recognitions

  • 2025 - Research.com Best Scientists Award
  • 2023 - Research.com Biology and Biochemistry in United States Leader Award
  • 2015 - Member of the National Academy of Sciences
  • 2009 - Member of the National Academy of Medicine (NAM)
  • 2009 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 2007 - Fellow of the American Psychological Association (APA)
  • 2005 - Fellow of the American Academy of Arts and Sciences

Overview

Alfred L. Goldberg was affiliated with Harvard University in the United States and was active in research primarily within the field of biochemistry, genetics, and molecular biology. Their work encompassed several subfields, including molecular biology, cell biology, genetics, epidemiology, and materials chemistry.

Their research focused heavily on topics related to ubiquitin and proteasome pathways, endoplasmic reticulum stress and disease, genetics and neurodevelopmental disorders, autophagy in disease and therapy, biochemical and molecular research, RNA and protein synthesis mechanisms, and protein degradation and inhibitors.

Frequent coauthors included G. Collins, Dong Hoon Lee, Si-Yi Chen, Ying Lu, and Jordan J. S. VerPlank.

Alfred L. Goldberg published several recent papers, among them:

  • cGMP via PKG activates 26S proteasomes and enhances degradation of proteins, including ones that cause neurodegenerative diseases, 2020, Proceedings of the National Academy of Sciences
  • Proteins containing ubiquitin-like (Ubl) domains not only bind to 26S proteasomes but also induce their activation, 2020, Proceedings of the National Academy of Sciences
  • An allosteric switch regulates Mycobacterium tuberculosis ClpP1P2 protease function as established by cryo-EM and methyl-TROSY NMR, 2020, Proceedings of the National Academy of Sciences
  • Mechanisms That Activate 26S Proteasomes and Enhance Protein Degradation, 2021, Biomolecules
  • Multiple myeloma cells are exceptionally sensitive to heat shock, which overwhelms their proteostasis network and induces apoptosis, 2020, Proceedings of the National Academy of Sciences

Their work was frequently published in the following venues:

  • Proceedings of the National Academy of Sciences
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Molecular Cell
  • Biomolecules
  • Brain

Throughout their career, Alfred L. Goldberg received multiple recognitions:

  • Member of the National Academy of Sciences (2015)
  • Fellow of the American Association for the Advancement of Science (AAAS) (2009)
  • Member of the National Academy of Medicine (NAM) (2009)
  • Fellow of the American Psychological Association (APA) (2007)
  • Fellow of the American Academy of Arts and Sciences (2005)

Alfred L. Goldberg's contributions to molecular biology and protein degradation pathways have left a record within academic literature primarily focusing on proteasome function and protein homeostasis mechanisms.

Best Publications

  • Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

    Kenneth L. Rock;Colette Gramm;Lisa Rothstein;Karen Clark

  • Foxo Transcription Factors Induce the Atrophy-Related Ubiquitin Ligase Atrogin-1 and Cause Skeletal Muscle Atrophy

    Marco Sandri;Claudia Sandri;Alex Gilbert;Carsten Skurk

  • Structure and Functions of the 20S and 26S Proteasomes

    Olivier Coux;Keiji Tanaka;Alfred L. Goldberg

  • Protein degradation and protection against misfolded or damaged proteins

    Alfred L. Goldberg

  • Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

    Daniel J. Klionsky;Hagai Abeliovich;Patrizia Agostinis;Devendra K. Agrawal

  • The ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB

    Vito J. Palombella;Oliver J. Rando;Alfred L. Goldberg;Tom Maniatis

  • Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy

    Marcelo D. Gomes;Stewart H. Lecker;R. Thomas Jagoe;Ami Navon

  • Proteasome inhibitors: valuable new tools for cell biologists.

    Do Hee Lee;Alfred L Goldberg

  • FoxO3 controls autophagy in skeletal muscle in vivo.

    Cristina Mammucari;Giulia Milan;Vanina Romanello;Eva Masiero

  • Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression

    Stewart H. Lecker;R. Thomas Jagoe;Alexander Gilbert;Marcelo Gomes

  • FoxO3 Coordinately Activates Protein Degradation by the Autophagic/Lysosomal and Proteasomal Pathways in Atrophying Muscle Cells

    Jinghui Zhao;Jeffrey J. Brault;Andreas Schild;Peirang Cao

  • Protein Degradation by the Ubiquitin–Proteasome Pathway in Normal and Disease States

    Stewart H. Lecker;Alfred L. Goldberg;William E. Mitch

  • Mechanisms of muscle wasting. The role of the ubiquitin-proteasome pathway.

    William E. Mitch;Alfred L. Goldberg

  • Proteasome inhibitors: from research tools to drug candidates

    Alexei F. Kisselev;Alfred L. Goldberg

  • Degradation of cell proteins and the generation of MHC class I-presented peptides.

    Kenneth L. Rock;Alfred L. Goldberg

  • Multiple proteolytic systems, including the proteasome, contribute to CFTR processing

    Timothy J. Jensen;Melinda A. Loo;Steven Pind;David B. Williams

  • Abnormal proteins serve as eukaryotic stress signals and trigger the activation of heat shock genes

    Jayakumar Ananthan;Alfred L. Goldberg;Richard Voellmy

  • Cellular defenses against unfolded proteins: a cell biologist thinks about neurodegenerative diseases.

    Michael Y. Sherman;Alfred L. Goldberg

  • Reversal of Cancer Cachexia and Muscle Wasting by ActRIIB Antagonism Leads to Prolonged Survival

    Xiaolan Zhou;Jin Lin Wang;John Lu;Yanping Song

  • Effects of insulin, glucose, and amino acids on protein turnover in rat diaphragm.

    Richard M. Fulks;Jeanne B. Li;Alfred L. Goldberg

Frequent Co-Authors

Kenneth L. Rock
Kenneth L. Rock University of Massachusetts Chan Medical School
Michael Y. Sherman
Michael Y. Sherman Ariel University
Chin Ha Chung
Chin Ha Chung Seoul National University
Steven P. Gygi
Steven P. Gygi Harvard University
Marco Sandri
Marco Sandri University of Padua
Tomo Saric
Tomo Saric University of Cologne
Vickie E. Baracos
Vickie E. Baracos University of Alberta
Tom Maniatis
Tom Maniatis Columbia University
Oliver J. Rando
Oliver J. Rando University of Massachusetts Chan Medical School
Daniel Finley
Daniel Finley Harvard University

External Links

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Best Scientists Citing Alfred L. Goldberg

Keiji Tanaka

Keiji Tanaka

Tokyo Metropolitan Institute of Medical Science

Publications: 210

Aaron Ciechanover

Aaron Ciechanover

Technion – Israel Institute of Technology

Publications: 136

Per-Olof Hasselgren

Per-Olof Hasselgren

Beth Israel Deaconess Medical Center

Publications: 128

Tilman Grune

Tilman Grune

University of Potsdam

Publications: 114

Wolfgang Baumeister

Wolfgang Baumeister

Max Planck Society

Publications: 112

Marco Sandri

Marco Sandri

University of Padua

Publications: 94

Kelvin J.A. Davies

Kelvin J.A. Davies

University of Southern California

Publications: 88

Daniel Finley

Daniel Finley

Harvard University

Publications: 84

Shigeo Murata

Shigeo Murata

University of Tokyo

Publications: 84

Michael Groll

Michael Groll

Technical University of Munich

Publications: 78

Martin Rechsteiner

Martin Rechsteiner

University of Utah

Publications: 74

Kenneth C. Anderson

Kenneth C. Anderson

Harvard University

Publications: 71

Josef E. Fischer

Josef E. Fischer

University of Cincinnati

Publications: 69

Ana Maria Cuervo

Ana Maria Cuervo

Albert Einstein College of Medicine

Publications: 69

Jeffrey L. Brodsky

Jeffrey L. Brodsky

University of Pittsburgh

Publications: 67

Michael J. Tisdale

Michael J. Tisdale

Aston University

Publications: 65

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