What is he best known for?
The fields of study he is best known for:
The scientist’s investigation covers issues in Biochemistry, Proteasome, Protein degradation, Cell biology and Proteolysis.
His Biochemistry research focuses on Epitope and how it relates to Peptide.
The concepts of his Proteasome study are interwoven with issues in Cell, Ubiquitin, Function and Enzyme.
While the research belongs to areas of Protein degradation, Alfred L. Goldberg spends his time largely on the problem of Muscle atrophy, intersecting his research to questions surrounding Regulation of gene expression, Gene expression, FOXO3 and Ubiquitin ligase.
Alfred L. Goldberg combines subjects such as Autophagy, Immune system, Molecular biology, Messenger RNA and Proteasome complex with his study of Cell biology.
The Proteolysis study combines topics in areas such as Proteases, Hsp70 and Adenosine triphosphate.
His most cited work include:
- Foxo Transcription Factors Induce the Atrophy-Related Ubiquitin Ligase Atrogin-1 and Cause Skeletal Muscle Atrophy (2183 citations)
- Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules (2179 citations)
- Structure and Functions of the 20S and 26S Proteasomes (2167 citations)
What are the main themes of his work throughout his whole career to date?
Biochemistry, Proteasome, Protein degradation, Cell biology and Ubiquitin are his primary areas of study.
Proteolysis, Protease, Enzyme, ATPase and Proteases are the primary areas of interest in his Biochemistry study.
His research investigates the link between Proteasome and topics such as Antigen presentation that cross with problems in MHC class I and Major histocompatibility complex.
His Protein degradation research integrates issues from Endocrinology, Internal medicine, Skeletal muscle, Protein catabolism and Protein biosynthesis.
His Skeletal muscle research is multidisciplinary, relying on both Protein turnover and Atrophy.
His Cell biology study combines topics from a wide range of disciplines, such as Autophagy and Cell.
He most often published in these fields:
- Biochemistry (59.26%)
- Proteasome (38.07%)
- Protein degradation (27.57%)
What were the highlights of his more recent work (between 2008-2020)?
- Proteasome (38.07%)
- Cell biology (26.34%)
- Ubiquitin (22.84%)
In recent papers he was focusing on the following fields of study:
Alfred L. Goldberg mostly deals with Proteasome, Cell biology, Ubiquitin, Biochemistry and Protein degradation.
His research in Proteasome intersects with topics in Autophagy, ATP hydrolysis, Protein subunit, Proteolysis and Phosphorylation.
In his research, mTORC1 is intimately related to Amino acid, which falls under the overarching field of Proteolysis.
His studies in Cell biology integrate themes in fields like Protein ubiquitination, Muscle atrophy and Cytosol.
His Ubiquitin study which covers Bortezomib that intersects with NFE2L1, MG132 and Unfolded protein response.
His study in Protein degradation is interdisciplinary in nature, drawing from both Molecular biology, Activator, Skeletal muscle, Cell cycle and Proteostasis.
Between 2008 and 2020, his most popular works were:
- Reversal of Cancer Cachexia and Muscle Wasting by ActRIIB Antagonism Leads to Prolonged Survival (656 citations)
- Muscle wasting in disease: molecular mechanisms and promising therapies (476 citations)
- During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation (454 citations)
In his most recent research, the most cited papers focused on:
Alfred L. Goldberg mainly investigates Proteasome, Biochemistry, Ubiquitin, Cell biology and Protein degradation.
His work focuses on many connections between Proteasome and other disciplines, such as Bortezomib, that overlap with his field of interest in Drug discovery, Pharmacology, Drug development and MG132.
His Ubiquitin research includes elements of ATP hydrolysis, Plasma protein binding and Proteolysis.
The various areas that Alfred L. Goldberg examines in his Cell biology study include Proteasome Binding and In vivo.
His study looks at the relationship between Protein degradation and fields such as Autophagy, as well as how they intersect with chemical problems.
His Ubiquitin ligase research incorporates elements of Endocrinology, Myofibril, Internal medicine, Muscle atrophy and Endosome.
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