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Alfred L. Goldberg

Alfred L. Goldberg

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Best Scientists
2025
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Biology and Biochemistry
USA
2023

D-Index & Metrics

Best Scientists

D-Index
189
Citations
128015
World Ranking
444
National Ranking
295

Biology and Biochemistry

D-Index
189
Citations
131053
World Ranking
48
National Ranking
41

Research.com Recognitions

  • 2025 - Research.com Best Scientists Award
  • 2023 - Research.com Biology and Biochemistry in United States Leader Award
  • 2015 - Member of the National Academy of Sciences
  • 2009 - Member of the National Academy of Medicine (NAM)
  • 2009 - Fellow of the American Association for the Advancement of Science (AAAS)
  • 2007 - Fellow of the American Psychological Association (APA)
  • 2005 - Fellow of the American Academy of Arts and Sciences

Overview

Alfred L. Goldberg was affiliated with Harvard University in the United States and was active in research primarily within the field of biochemistry, genetics, and molecular biology. Their work encompassed several subfields, including molecular biology, cell biology, genetics, epidemiology, and materials chemistry.

Their research focused heavily on topics related to ubiquitin and proteasome pathways, endoplasmic reticulum stress and disease, genetics and neurodevelopmental disorders, autophagy in disease and therapy, biochemical and molecular research, RNA and protein synthesis mechanisms, and protein degradation and inhibitors.

Frequent coauthors included G. Collins, Dong Hoon Lee, Si-Yi Chen, Ying Lu, and Jordan J. S. VerPlank.

Alfred L. Goldberg published several recent papers, among them:

  • cGMP via PKG activates 26S proteasomes and enhances degradation of proteins, including ones that cause neurodegenerative diseases, 2020, Proceedings of the National Academy of Sciences
  • Proteins containing ubiquitin-like (Ubl) domains not only bind to 26S proteasomes but also induce their activation, 2020, Proceedings of the National Academy of Sciences
  • An allosteric switch regulates Mycobacterium tuberculosis ClpP1P2 protease function as established by cryo-EM and methyl-TROSY NMR, 2020, Proceedings of the National Academy of Sciences
  • Mechanisms That Activate 26S Proteasomes and Enhance Protein Degradation, 2021, Biomolecules
  • Multiple myeloma cells are exceptionally sensitive to heat shock, which overwhelms their proteostasis network and induces apoptosis, 2020, Proceedings of the National Academy of Sciences

Their work was frequently published in the following venues:

  • Proceedings of the National Academy of Sciences
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Molecular Cell
  • Biomolecules
  • Brain

Throughout their career, Alfred L. Goldberg received multiple recognitions:

  • Member of the National Academy of Sciences (2015)
  • Fellow of the American Association for the Advancement of Science (AAAS) (2009)
  • Member of the National Academy of Medicine (NAM) (2009)
  • Fellow of the American Psychological Association (APA) (2007)
  • Fellow of the American Academy of Arts and Sciences (2005)

Alfred L. Goldberg's contributions to molecular biology and protein degradation pathways have left a record within academic literature primarily focusing on proteasome function and protein homeostasis mechanisms.

Best Publications

  • Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

    Kenneth L. Rock;Colette Gramm;Lisa Rothstein;Karen Clark

  • Foxo Transcription Factors Induce the Atrophy-Related Ubiquitin Ligase Atrogin-1 and Cause Skeletal Muscle Atrophy

    Marco Sandri;Claudia Sandri;Alex Gilbert;Carsten Skurk

  • Structure and Functions of the 20S and 26S Proteasomes

    Olivier Coux;Keiji Tanaka;Alfred L. Goldberg

  • Protein degradation and protection against misfolded or damaged proteins

    Alfred L. Goldberg

  • Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

    Daniel J. Klionsky;Hagai Abeliovich;Patrizia Agostinis;Devendra K. Agrawal

  • The ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB

    Vito J. Palombella;Oliver J. Rando;Alfred L. Goldberg;Tom Maniatis

  • Atrogin-1, a muscle-specific F-box protein highly expressed during muscle atrophy

    Marcelo D. Gomes;Stewart H. Lecker;R. Thomas Jagoe;Ami Navon

  • Proteasome inhibitors: valuable new tools for cell biologists.

    Do Hee Lee;Alfred L Goldberg

  • FoxO3 controls autophagy in skeletal muscle in vivo.

    Cristina Mammucari;Giulia Milan;Vanina Romanello;Eva Masiero

  • Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression

    Stewart H. Lecker;R. Thomas Jagoe;Alexander Gilbert;Marcelo Gomes

  • FoxO3 Coordinately Activates Protein Degradation by the Autophagic/Lysosomal and Proteasomal Pathways in Atrophying Muscle Cells

    Jinghui Zhao;Jeffrey J. Brault;Andreas Schild;Peirang Cao

  • Protein Degradation by the Ubiquitin–Proteasome Pathway in Normal and Disease States

    Stewart H. Lecker;Alfred L. Goldberg;William E. Mitch

  • Mechanisms of muscle wasting. The role of the ubiquitin-proteasome pathway.

    William E. Mitch;Alfred L. Goldberg

  • Proteasome inhibitors: from research tools to drug candidates

    Alexei F. Kisselev;Alfred L. Goldberg

  • Degradation of cell proteins and the generation of MHC class I-presented peptides.

    Kenneth L. Rock;Alfred L. Goldberg

  • Multiple proteolytic systems, including the proteasome, contribute to CFTR processing

    Timothy J. Jensen;Melinda A. Loo;Steven Pind;David B. Williams

  • Abnormal proteins serve as eukaryotic stress signals and trigger the activation of heat shock genes

    Jayakumar Ananthan;Alfred L. Goldberg;Richard Voellmy

  • Cellular defenses against unfolded proteins: a cell biologist thinks about neurodegenerative diseases.

    Michael Y. Sherman;Alfred L. Goldberg

  • Reversal of Cancer Cachexia and Muscle Wasting by ActRIIB Antagonism Leads to Prolonged Survival

    Xiaolan Zhou;Jin Lin Wang;John Lu;Yanping Song

  • Effects of insulin, glucose, and amino acids on protein turnover in rat diaphragm.

    Richard M. Fulks;Jeanne B. Li;Alfred L. Goldberg

Frequent Co-Authors

Kenneth L. Rock
Kenneth L. Rock University of Massachusetts Chan Medical School
Michael Y. Sherman
Michael Y. Sherman Ariel University
Chin Ha Chung
Chin Ha Chung Seoul National University
Steven P. Gygi
Steven P. Gygi Harvard University
Marco Sandri
Marco Sandri University of Padua
Tomo Saric
Tomo Saric University of Cologne
Vickie E. Baracos
Vickie E. Baracos University of Alberta
Tom Maniatis
Tom Maniatis Columbia University
Oliver J. Rando
Oliver J. Rando University of Massachusetts Chan Medical School
Daniel Finley
Daniel Finley Harvard University

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