D-Index & Metrics Best Publications

D-Index & Metrics

Discipline name D-index D-index (Discipline H-index) only includes papers and citation values for an examined discipline in contrast to General H-index which accounts for publications across all disciplines. Citations Publications World Ranking National Ranking
Medicine D-index 77 Citations 19,352 298 World Ranking 11174 National Ranking 5974

Overview

What is he best known for?

The fields of study he is best known for:

  • Internal medicine
  • Gene
  • Enzyme

Per-Olof Hasselgren mostly deals with Internal medicine, Endocrinology, Skeletal muscle, Sepsis and Protein catabolism. He interconnects Signal transduction and Protein degradation in the investigation of issues within Internal medicine. His work deals with themes such as Tyrosine and Intestinal mucosa, which intersect with Endocrinology.

The concepts of his Skeletal muscle study are interwoven with issues in Ubiquitin, Protein metabolism, Catabolism, Muscle tissue and Calpain. His studies deal with areas such as Tumor necrosis factor alpha, Interleukin 6, Cytokine and Pathophysiology as well as Sepsis. His Protein catabolism study combines topics from a wide range of disciplines, such as Surgery, Myofibril and Pathology.

His most cited work include:

  • IKKβ/NF-κB Activation Causes Severe Muscle Wasting in Mice (1044 citations)
  • IKKβ/NF-κB Activation Causes Severe Muscle Wasting in Mice (1044 citations)
  • Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat (477 citations)

What are the main themes of his work throughout his whole career to date?

His scientific interests lie mostly in Internal medicine, Endocrinology, Skeletal muscle, Sepsis and Protein catabolism. Internal medicine is frequently linked to Protein turnover in his study. His studies in Endocrinology integrate themes in fields like Amino acid, Tyrosine, Protein degradation and Protein biosynthesis.

His Skeletal muscle research incorporates elements of Ubiquitin, Biochemistry, Proteolysis, Molecular biology and Calpain. Per-Olof Hasselgren has included themes like Small intestine, Intestinal mucosa and In vivo in his Sepsis study. His Protein catabolism study incorporates themes from Muscle tissue, Soleus muscle, Cachexia and Myofibril.

He most often published in these fields:

  • Internal medicine (59.60%)
  • Endocrinology (57.91%)
  • Skeletal muscle (34.18%)

What were the highlights of his more recent work (between 2004-2021)?

  • Internal medicine (59.60%)
  • Endocrinology (57.91%)
  • Skeletal muscle (34.18%)

In recent papers he was focusing on the following fields of study:

Per-Olof Hasselgren spends much of his time researching Internal medicine, Endocrinology, Skeletal muscle, Myogenesis and Muscle atrophy. The Internal medicine study combines topics in areas such as PI3K/AKT/mTOR pathway and MAPK/ERK pathway. His Endocrinology research includes elements of Muscle weakness and Phosphorylation.

His study on Skeletal muscle also encompasses disciplines like

  • Calpain together with Protein catabolism, Cathepsin L, Myofilament and Sarcomere,
  • Myocyte, which have a strong connection to Trichostatin A, Ubiquitin ligase and Histone deacetylase. The various areas that Per-Olof Hasselgren examines in his Myogenesis study include Molecular biology, Muscle hypertrophy and Protein degradation. His Protein degradation study combines topics in areas such as Ubiquitin and Proteolysis.

Between 2004 and 2021, his most popular works were:

  • Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat (477 citations)
  • DEXAMETHASONE AND CORTICOSTERONE INDUCE SIMILAR, BUT NOT IDENTICAL, MUSCLE WASTING RESPONSES IN CULTURED L6 AND C2C12 MYOTUBES (126 citations)
  • Treatment of rats with calpain inhibitors prevents sepsis-induced muscle proteolysis independent of atrogin-1/MAFbx and MuRF1 expression (111 citations)

In his most recent research, the most cited papers focused on:

  • Internal medicine
  • Gene
  • Enzyme

Internal medicine, Endocrinology, Skeletal muscle, Wasting and Muscle atrophy are his primary areas of study. His research integrates issues of Protein degradation, Enhancer binding and Phosphorylation in his study of Internal medicine. Per-Olof Hasselgren combines subjects such as Glycogen synthase, Protein catabolism, Muscle weakness, Calpain and Myocyte with his study of Skeletal muscle.

While the research belongs to areas of Wasting, Per-Olof Hasselgren spends his time largely on the problem of Transcription factor, intersecting his research to questions surrounding Regulation of gene expression. His Glucocorticoid research includes themes of Signal transduction, Intensive care and Proteasome. In Resveratrol, Per-Olof Hasselgren works on issues like FOXO1, which are connected to Sepsis.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

IKKβ/NF-κB Activation Causes Severe Muscle Wasting in Mice

Dongsheng Cai;J. Daniel Frantz;J. Daniel Frantz;Nicholas E. Tawa;Nicholas E. Tawa;Peter A. Melendez;Peter A. Melendez.
Cell (2004)

1403 Citations

Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat

Aaron M Cypess;Andrew P White;Cecile Vernochet;Tim J Schulz.
Nature Medicine (2013)

603 Citations

Glucocorticoids and muscle catabolism.

Per-Olof Hasselgren.
Current Opinion in Clinical Nutrition and Metabolic Care (1999)

372 Citations

Muscle cachexia: current concepts of intracellular mechanisms and molecular regulation.

Per-Olof Hasselgren;Josef E. Fischer.
Annals of Surgery (2001)

370 Citations

Sepsis stimulates nonlysosomal, energy-dependent proteolysis and increases ubiquitin mRNA levels in rat skeletal muscle.

Greg Tiao;J. M. Fagan;N. Samuels;J. H. James.
Journal of Clinical Investigation (1994)

349 Citations

Sepsis is associated with increased mRNAs of the ubiquitin-proteasome proteolytic pathway in human skeletal muscle.

Greg Tiao;Scott Hobler;Jing Jing Wang;Tory A. Meyer.
Journal of Clinical Investigation (1997)

349 Citations

Energy-ubiquitin-dependent muscle proteolysis during sepsis in rats is regulated by glucocorticoids.

G. Tiao;J. Fagan;V. Roegner;M. Lieberman.
Journal of Clinical Investigation (1996)

342 Citations

Sepsis upregulates the gene expression of multiple ubiquitin ligases in skeletal muscle

Curtis J Wray;Joshua M V Mammen;Joshua M V Mammen;Dan D. Hershko;Dan D. Hershko;Per Olof Hasselgren.
The International Journal of Biochemistry & Cell Biology (2003)

293 Citations

The expression of genes in the ubiquitin-proteasome proteolytic pathway is increased in skeletal muscle from patients with cancer

Arthur Williams;Xiaoyan Sun;Josef E. Fischer;Per-Olof Hasselgren.
Surgery (1999)

250 Citations

Sepsis stimulates release of myofilaments in skeletal muscle by a calcium-dependent mechanism

Arthur B. Williams;Gabrielle M. Decourten‐Myers;Josef E. Fischer;Guangju Luo.
The FASEB Journal (1999)

247 Citations

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