Per-Olof Hasselgren mostly deals with Internal medicine, Endocrinology, Skeletal muscle, Sepsis and Protein catabolism. He interconnects Signal transduction and Protein degradation in the investigation of issues within Internal medicine. His work deals with themes such as Tyrosine and Intestinal mucosa, which intersect with Endocrinology.
The concepts of his Skeletal muscle study are interwoven with issues in Ubiquitin, Protein metabolism, Catabolism, Muscle tissue and Calpain. His studies deal with areas such as Tumor necrosis factor alpha, Interleukin 6, Cytokine and Pathophysiology as well as Sepsis. His Protein catabolism study combines topics from a wide range of disciplines, such as Surgery, Myofibril and Pathology.
His scientific interests lie mostly in Internal medicine, Endocrinology, Skeletal muscle, Sepsis and Protein catabolism. Internal medicine is frequently linked to Protein turnover in his study. His studies in Endocrinology integrate themes in fields like Amino acid, Tyrosine, Protein degradation and Protein biosynthesis.
His Skeletal muscle research incorporates elements of Ubiquitin, Biochemistry, Proteolysis, Molecular biology and Calpain. Per-Olof Hasselgren has included themes like Small intestine, Intestinal mucosa and In vivo in his Sepsis study. His Protein catabolism study incorporates themes from Muscle tissue, Soleus muscle, Cachexia and Myofibril.
Per-Olof Hasselgren spends much of his time researching Internal medicine, Endocrinology, Skeletal muscle, Myogenesis and Muscle atrophy. The Internal medicine study combines topics in areas such as PI3K/AKT/mTOR pathway and MAPK/ERK pathway. His Endocrinology research includes elements of Muscle weakness and Phosphorylation.
His study on Skeletal muscle also encompasses disciplines like
Internal medicine, Endocrinology, Skeletal muscle, Wasting and Muscle atrophy are his primary areas of study. His research integrates issues of Protein degradation, Enhancer binding and Phosphorylation in his study of Internal medicine. Per-Olof Hasselgren combines subjects such as Glycogen synthase, Protein catabolism, Muscle weakness, Calpain and Myocyte with his study of Skeletal muscle.
While the research belongs to areas of Wasting, Per-Olof Hasselgren spends his time largely on the problem of Transcription factor, intersecting his research to questions surrounding Regulation of gene expression. His Glucocorticoid research includes themes of Signal transduction, Intensive care and Proteasome. In Resveratrol, Per-Olof Hasselgren works on issues like FOXO1, which are connected to Sepsis.
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IKKβ/NF-κB Activation Causes Severe Muscle Wasting in Mice
Dongsheng Cai;J. Daniel Frantz;J. Daniel Frantz;Nicholas E. Tawa;Nicholas E. Tawa;Peter A. Melendez;Peter A. Melendez.
Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat
Aaron M Cypess;Andrew P White;Cecile Vernochet;Tim J Schulz.
Nature Medicine (2013)
Glucocorticoids and muscle catabolism.
Current Opinion in Clinical Nutrition and Metabolic Care (1999)
Muscle cachexia: current concepts of intracellular mechanisms and molecular regulation.
Per-Olof Hasselgren;Josef E. Fischer.
Annals of Surgery (2001)
Sepsis stimulates nonlysosomal, energy-dependent proteolysis and increases ubiquitin mRNA levels in rat skeletal muscle.
Greg Tiao;J. M. Fagan;N. Samuels;J. H. James.
Journal of Clinical Investigation (1994)
Sepsis is associated with increased mRNAs of the ubiquitin-proteasome proteolytic pathway in human skeletal muscle.
Greg Tiao;Scott Hobler;Jing Jing Wang;Tory A. Meyer.
Journal of Clinical Investigation (1997)
Energy-ubiquitin-dependent muscle proteolysis during sepsis in rats is regulated by glucocorticoids.
G. Tiao;J. Fagan;V. Roegner;M. Lieberman.
Journal of Clinical Investigation (1996)
Sepsis upregulates the gene expression of multiple ubiquitin ligases in skeletal muscle
Curtis J Wray;Joshua M V Mammen;Joshua M V Mammen;Dan D. Hershko;Dan D. Hershko;Per Olof Hasselgren.
The International Journal of Biochemistry & Cell Biology (2003)
The expression of genes in the ubiquitin-proteasome proteolytic pathway is increased in skeletal muscle from patients with cancer
Arthur Williams;Xiaoyan Sun;Josef E. Fischer;Per-Olof Hasselgren.
Sepsis stimulates release of myofilaments in skeletal muscle by a calcium-dependent mechanism
Arthur B. Williams;Gabrielle M. Decourten‐Myers;Josef E. Fischer;Guangju Luo.
The FASEB Journal (1999)
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