World's Best Scientists 2026 revealed!

D-Index & Metrics

Medicine

D-Index
93
Citations
60031
World Ranking
10649
National Ranking
5476

Overview

William E. Mitch is affiliated with Baylor College of Medicine in the United States. Their research work spans multiple areas primarily within medicine and biochemistry, genetics, and molecular biology. Mitch's scientific contributions focus extensively on nephrology, physiology, and molecular biology, addressing complex issues in chronic kidney disease and related metabolic conditions.

Their recent papers reflect investigations into muscle loss mechanisms, kidney disease complications, and insulin resistance pathways. Notable publications include:

  • Pathophysiological mechanisms leading to muscle loss in chronic kidney disease, 2021, Nature Reviews Nephrology
  • Chronic kidney disease promotes atrial fibrillation via inflammasome pathway activation, 2023, Journal of Clinical Investigation
  • Stat3 activation induces insulin resistance via a muscle-specific E3 ubiquitin ligase Fbxo40, 2020, American Journal of Physiology-Endocrinology and Metabolism
  • PDGFRA in vascular adventitial MSCs promotes neointima formation in arteriovenous fistula in chronic kidney disease, 2020, JCI Insight
  • Phosphoinositide 3-kinase γ deficiency attenuates kidney injury and fibrosis in angiotensin II-induced hypertension, 2020, Nephrology Dialysis Transplantation

Mitch collaborates regularly with a group of frequent co-authors, including Jizhong Cheng, Sandhya S. Thomas, Qunying Guo, Luan D. Truong, and Jiao Wu. Their teamwork has resulted in multiple joint publications.

Their work appears frequently in key nephrology and physiology journals. Frequent publication venues include:

  • Journal of the American Society of Nephrology
  • Nature Reviews Nephrology
  • Journal of Clinical Investigation
  • American Journal of Physiology-Endocrinology and Metabolism
  • JCI Insight

William E. Mitch's research covers a range of interconnected medical subfields, with a concentration on nephrology, physiology, molecular biology, cell biology, and surgery. These areas underpin their investigation of chronic kidney disease, renal disease management, and metabolic disorders.

Main topics addressed in their research include:

  • Dialysis and renal disease management
  • Nutrition and health in aging
  • Muscle metabolism and nutrition
  • Chronic kidney disease and diabetes
  • Muscle physiology and disorders
  • Pancreatic function and diabetes
  • Adipokines, inflammation, and metabolic diseases

Best Publications

  • EFFECTS OF LOSARTAN ON RENAL AND CARDIOVASCULAR OUTCOMES IN PATIENTS WITH TYPE 2 DIABETES AND NEPHROPATHY

    Barry M. Brenner;Mark E. Cooper;Dick De Zeeuw;William F. Keane

  • AHA Dietary Guidelines Revision 2000: A Statement for Healthcare Professionals From the Nutrition Committee of the American Heart Association

    Ronald M. Krauss;Robert H. Eckel;Barbara Howard;Lawrence J. Appel

  • Diabetes and cardiovascular disease : A statement for healthcare professionals from the American heart association

    Scott M. Grundy;Ivor J. Benjamin;Gregory L. Burke;Alan Chait

  • Cachexia: a new definition.

    William J. Evans;John E. Morley;Josep Argilés;Connie Bales

  • A proposed nomenclature and diagnostic criteria for protein–energy wasting in acute and chronic kidney disease

    D. Fouque;K. Kalantar-Zadeh;J. Kopple;N. Cano

  • Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension

    Ulf Landmesser;Sergey Dikalov;S. Russ Price;Louise McCann

  • Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression

    Stewart H. Lecker;R. Thomas Jagoe;Alexander Gilbert;Marcelo Gomes

  • Protein Degradation by the Ubiquitin–Proteasome Pathway in Normal and Disease States

    Stewart H. Lecker;Alfred L. Goldberg;William E. Mitch

  • Mechanisms of muscle wasting. The role of the ubiquitin-proteasome pathway.

    William E. Mitch;Alfred L. Goldberg

  • Proteinuria, a target for renoprotection in patients with type 2 diabetic nephropathy: Lessons from RENAAL

    Dick De Zeeuw;Giuseppe Remuzzi;Hans Henrik Parving;William F. Keane

  • Albuminuria, a Therapeutic Target for Cardiovascular Protection in Type 2 Diabetic Patients With Nephropathy

    Dick De Zeeuw;Giuseppe Remuzzi;Hans Henrik Parving;William F. Keane

  • Etiology of the Protein-Energy Wasting Syndrome in Chronic Kidney Disease: A Consensus Statement From the International Society of Renal Nutrition and Metabolism (ISRNM)

    Juan Jesús Carrero;Peter Stenvinkel;Lilian Cuppari;T. Alp Ikizler

  • Muscle Protein Breakdown and the Critical Role of the Ubiquitin-Proteasome Pathway in Normal and Disease States

    Stewart H. Lecker;Vered Solomon;William E. Mitch;Alfred L. Goldberg

  • A method for estimating nitrogen intake of patients with chronic renal failure

    Bradley J. Maroni;Theodore I. Steinman;William E. Mitch

  • Activation of caspase-3 is an initial step triggering accelerated muscle proteolysis in catabolic conditions

    Jie Du;Xiaonan Wang;Christiane Miereles;James L. Bailey

  • The risk of developing end-stage renal disease in patients with type 2 diabetes and nephropathy: the RENAAL study.

    William F. Keane;Barry M. Brenner;Dick de Zeeuw;Jean-Pierre Grunfeld

  • A SIMPLE METHOD OF ESTIMATING PROGRESSION OF CHRONIC RENAL FAILURE

    W.E. Mitch;M. Walser;G.A. Buffington;J. Lemann

  • Insulin resistance accelerates muscle protein degradation: Activation of the ubiquitin-proteasome pathway by defects in muscle cell signaling.

    Xiaonan Wang;Zhaoyong Hu;Junping Hu;Jie Du

  • Mechanisms of muscle wasting in chronic kidney disease

    Xiaonan H. Wang;William E. Mitch

  • Development and Progression of Renal Disease in Pima Indians with Non-Insulin-Dependent Diabetes Mellitus

    Robert G. Nelson;Peter H. Bennett;Gerald J. Beck;Ming Tan

Frequent Co-Authors

Jie Du
Jie Du Capital Medical University
Denis Fouque
Denis Fouque Hôpital Édouard-Herriot
Joel D. Kopple
Joel D. Kopple University of California, Los Angeles
T. Alp Ikizler
T. Alp Ikizler Vanderbilt University Medical Center
Alfred L. Goldberg
Alfred L. Goldberg Harvard University
Kamyar Kalantar-Zadeh
Kamyar Kalantar-Zadeh University of California, Irvine
Dick de Zeeuw
Dick de Zeeuw University of Groningen
Giuseppe Remuzzi
Giuseppe Remuzzi Mario Negri Institute for Pharmacological Research
William F. Keane
William F. Keane University of Minnesota
George A. Kaysen
George A. Kaysen University of California, Davis

If you think any of the details on this page are incorrect, let us know.

Report an issue

We appreciate your kind effort to assist us to improve this page, it would be helpful providing us with as much detail as possible in the text box below:

Related Online Degrees & Career Pathways

Studying Medicine in the USA opens the door to many online degrees and diverse healthcare careers. For registered nurses, advancing your education can be streamlined through adn to np bridge programs, which provide an accessible way for ADN-prepared nurses to work toward becoming nurse practitioners.

If you’re interested in nutrition and wellness, earning an online dietitian degree can help prepare you for roles in clinical settings, community health, or even private practice. For those aiming for healthcare management or policy careers, choosing one of the cahme-accredited online mha programs ensures you receive a high standard of education recognized by the industry.

Some nurses seek flexible programs, and there are rn to bsn programs no clinicals for those who want to advance without additional on-site clinical requirements. These online pathways help busy healthcare professionals gain valuable skills while balancing work and study, supporting career growth in today’s evolving medical landscape.

Best Scientists Citing William E. Mitch

Trending Scientists