World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
91
Citations
46813
World Ranking
2273
National Ranking
1218

Overview

David J. Glass is affiliated with Regeneron in the United States and specializes in research primarily within the fields of Medicine and Biochemistry, Genetics, and Molecular Biology. Their work spans several subfields, including Molecular Biology, Physiology, Epidemiology, Rheumatology, and Immunology.

The scientist has contributed to a range of topics predominantly focused on Muscle Physiology and Disorders, Ubiquitin and proteasome pathways, Nutrition and Health in Aging, GDF15 and Related Biomarkers, Autophagy in Disease and Therapy, Acute Myeloid Leukemia Research, and Genetics, Aging, and Longevity in Model Organisms.

Among recent publications authored or co-authored by David J. Glass are:

  • Common and rare variant associations with clonal haematopoiesis phenotypes (2022, Nature)
  • Protein signatures of centenarians and their offspring suggest centenarians age slower than other humans (2021, Aging Cell)
  • ARDD 2020: from aging mechanisms to interventions (2020, Aging)
  • The prevalence of low muscle mass associated with obesity in the USA (2022, Skeletal Muscle)
  • Dual roles of mTORC1-dependent activation of the ubiquitin-proteasome system in muscle proteostasis (2022, Communications Biology)

The scientist frequently publishes in venues such as bioRxiv (Cold Spring Harbor Laboratory), Nature, Skeletal Muscle, UNC Libraries, and Aging.

David J. Glass has collaborated extensively with several co-authors, including Gurinder S. Atwal, Tea Shavlakadze, Alan R. Shuldiner, John D. Overton, and Aris Baras, with multiple joint publications recorded.

Best Publications

  • Identification of Ubiquitin Ligases Required for Skeletal Muscle Atrophy

    Sue C. Bodine;Esther Latres;Susanne Baumhueter;Venus K.-M. Lai

  • Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo.

    Sue C. Bodine;Trevor N. Stitt;Michael Gonzalez;William O. Kline

  • The IGF-1/PI3K/Akt Pathway Prevents Expression of Muscle Atrophy-Induced Ubiquitin Ligases by Inhibiting FOXO Transcription Factors

    Trevor N. Stitt;Doreen Drujan;Brian A. Clarke;Frank Panaro

  • Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways

    Christian Rommel;Sue C. Bodine;Brian A. Clarke;Roni Rossman

  • IKKβ/NF-κB Activation Causes Severe Muscle Wasting in Mice

    Dongsheng Cai;J. Daniel Frantz;J. Daniel Frantz;Nicholas E. Tawa;Nicholas E. Tawa;Peter A. Melendez;Peter A. Melendez

  • Skeletal muscle hypertrophy and atrophy signaling pathways.

    David J. Glass

  • Cancer cachexia: mediators, signaling, and metabolic pathways.

    Kenneth C.H. Fearon;David J. Glass;Denis C. Guttridge

  • The Receptor Tyrosine Kinase MuSK Is Required for Neuromuscular Junction Formation In Vivo

    Thomas M DeChiara;David C Bowen;David M Valenzuela;Mary V Simmons

  • Differentiation Stage-Specific Inhibition of the Raf-MEK-ERK Pathway by Akt

    Christian Rommel;Brian A. Clarke;Sven Zimmermann;Lorna Nuñez

  • trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor

    Stephen P. Squinto;Trevor N. Stitt;Thomas H. Aldrich;Samuel Davis

  • The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases

    Trevor N Stitt;Greg Conn;Martin Goret;Martin Goret;Cary Lai

  • Signalling pathways that mediate skeletal muscle hypertrophy and atrophy

    David J. Glass

  • Myostatin reduces Akt/TORC1/p70S6K signaling, inhibiting myoblast differentiation and myotube size

    Anne Ulrike Trendelenburg;Angelika Meyer;Daisy Rohner;Joseph Boyle

  • Agrin Acts via a MuSK Receptor Complex

    David J Glass;David C Bowen;Trevor N Stitt;Czeslaw Radziejewski

  • mTOR inhibition improves immune function in the elderly

    Joan B. Mannick;Giuseppe Del Giudice;Maria Lattanzi;Nicholas M. Valiante

  • The E3 Ligase MuRF1 degrades myosin heavy chain protein in dexamethasone-treated skeletal muscle.

    Brian A. Clarke;Doreen Drujan;Monte S. Willis;Leon O. Murphy

  • During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation

    Shenhav Orit Cohen;Jeffrey J. Brault;Steven P. Gygi;David Jonathan Glass

  • Similarities and differences in the way neurotrophins interact with the Trk receptors in neuronal and nonneuronal cells.

    Nancy Y. Ip;Trevor N. Stitt;Peter Tapley;Rudiger Klein

  • An orphan receptor tyrosine kinase family whose members serve as nonintegrin collagen receptors

    Ajay Shrivastava;Czeslaw Radziejewski;Ernest Campbell;Lubomir Kovac

  • Short Article The IGF-1/PI3K/Akt Pathway Prevents Expression of Muscle Atrophy-Induced Ubiquitin Ligases by Inhibiting FOXO Transcription Factors

    Trevor N. Stitt;Doreen Drujan;Brian A. Clarke;Frank Panaro

Frequent Co-Authors

George D. Yancopoulos
George D. Yancopoulos Regeneron (United States)
Michael C. Milone
Michael C. Milone University of Pennsylvania
Ronenn Roubenoff
Ronenn Roubenoff Novartis (Switzerland)
Peter H. Schur
Peter H. Schur Brigham and Women's Hospital
David L. Porter
David L. Porter University of Pennsylvania
Nancy Y. Ip
Nancy Y. Ip Hong Kong University of Science and Technology
David M. Valenzuela
David M. Valenzuela Regeneron (United States)
Joshua R. Sanes
Joshua R. Sanes Harvard University
Carl H. June
Carl H. June University of Pennsylvania
Susan T. Lovett
Susan T. Lovett Brandeis University

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