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Markus A. Rüegg

Markus A. Rüegg

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Biology and Biochemistry
Switzerland
2023

D-Index & Metrics

Biology and Biochemistry

D-Index
86
Citations
32990
World Ranking
2925
National Ranking
62

Research.com Recognitions

  • 2023 - Research.com Biology and Biochemistry in Switzerland Leader Award

Overview

Markus A. Rüegg is affiliated with the University of Basel in Switzerland and has a research focus primarily within biochemistry, genetics, and molecular biology, with significant contributions also in medicine. Their work spans numerous subfields, notably molecular biology, cellular and molecular neuroscience, physiology, immunology and allergy, and genetics.

The scientist has addressed various main topics in their research, including muscle physiology and disorders, cell adhesion molecules research, RNA research and splicing, genetic neurodegenerative diseases, adipose tissue and metabolism, cardiomyopathy and myosin studies, and genetics, aging, and longevity in model organisms.

Markus A. Rüegg's recent publications illustrate their engagement with muscle biology and neuromuscular signaling, with selected works such as:

  • The neuromuscular junction is a focal point of mTORC1 signaling in sarcopenia, 2020, Nature Communications
  • Distinct and additive effects of calorie restriction and rapamycin in aging skeletal muscle, 2022, Nature Communications
  • Molecular and phenotypic analysis of rodent models reveals conserved and species-specific modulators of human sarcopenia, 2021, Communications Biology
  • Dual roles of mTORC1-dependent activation of the ubiquitin-proteasome system in muscle proteostasis, 2022, Communications Biology
  • The TOR Pathway at the Neuromuscular Junction: More Than a Metabolic Player?, 2020, Frontiers in Molecular Neuroscience

The body of work has appeared predominantly in several key publication venues, which include:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature Communications
  • Neuromuscular Disorders
  • Communications Biology
  • Frontiers in Molecular Neuroscience

Markus A. Rüegg frequently collaborates with a group of researchers who have co-authored multiple papers. These colleagues include Shuo Lin, Daniel J. Ham, Lionel Tintignac, Marco Thürkauf, and Judith Reinhard.

Best Publications

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive

    Estela Jacinto;Robbie Loewith;Anja Schmidt;Shuo Lin

  • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • Neuropathology in Mice Expressing Human α-Synuclein

    Herman van der Putten;Karl-Heinz Wiederhold;Alphonse Probst;Samuel Barbieri

  • Skeletal Muscle-Specific Ablation of raptor, but Not of rictor, Causes Metabolic Changes and Results in Muscle Dystrophy

    C. Florian Bentzinger;Klaas Romanino;Dimitri Cloëtta;Shuo Lin

  • Hepatic mTORC2 activates glycolysis and lipogenesis through Akt, glucokinase, and SREBP1c.

    Asami Hagiwara;Marion Cornu;Nadine Cybulski;Pazit Polak

  • mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice

    Ken Inoki;Hiroyuki Mori;Junying Wang;Tsukasa Suzuki

  • Role of mTOR in podocyte function and diabetic nephropathy in humans and mice

    Markus Gödel;Björn Hartleben;Nadja Herbach;Shuya Liu

  • Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration.

    Pazit Polak;Nadine Cybulski;Jerome N. Feige;Johan Auwerx

  • New insights into the roles of agrin

    Gabriela Bezakova;Markus A. Ruegg

  • Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy

    Valérie Risson;Laetitia Mazelin;Mila Roceri;Hervé Sanchez

  • Mechanisms Regulating Neuromuscular Junction Development and Function and Causes of Muscle Wasting

    Lionel A. Tintignac;Hans-Rudolf Brenner;Markus A. Rüegg

  • The agrin gene codes for a family of basal lamina proteins that differ in function and distribution

    Markus A. Ruegg;Karl W.K. Tsim;Sharon E. Horton;Stephan Kröger

  • Acetylcholine receptor-aggregating activity of agrin isoforms and mapping of the active site.

    M Gesemann;A J Denzer;M A Ruegg

  • Guidelines for preclinical animal research in ALS/MND: A consensus meeting.

    Albert C. Ludolph;Caterina Bendotti;Eran Blaugrund;Adriano Chio

  • Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

    Daniel J. Klionsky;Kotb Abdelmohsen;Akihisa Abe;Joynal Abedin

  • cDNA that encodes active agrin.

    Karl Wah Keung Tsim;Markus Andreas Rüegg;Gérard Escher;Stephan Kröger

  • Alternative Splicing of Agrin Alters Its Binding to Heparin, Dystroglycan, and the Putative Agrin Receptor

    Matthias Gesemann;Valeria Cavalli;Alain J Denzer;Andrea Brancaccio

  • Ablation of the mTORC2 component rictor in brain or Purkinje cells affects size and neuron morphology

    Venus Thomanetz;Nico Angliker;Dimitri Cloëtta;Regula M. Lustenberger

  • Sustained Activation of mTORC1 in Skeletal Muscle Inhibits Constitutive and Starvation-Induced Autophagy and Causes a Severe, Late-Onset Myopathy

    Perrine Castets;Shuo Lin;Nathalie Rion;Sabrina Di Fulvio

Frequent Co-Authors

Michael N. Hall
Michael N. Hall University of Basel
Tobias B. Huber
Tobias B. Huber Universität Hamburg
Peter D. Yurchenco
Peter D. Yurchenco Rutgers, The State University of New Jersey
Stephan Kröger
Stephan Kröger Ludwig-Maximilians-Universität München
Jürgen Engel
Jürgen Engel University of Basel
Francesco Zorzato
Francesco Zorzato University of Ferrara
Richard A. Kammerer
Richard A. Kammerer Paul Scherrer Institute
Evelina Gatti
Evelina Gatti Aix-Marseille University
Shazib Pervaiz
Shazib Pervaiz National University of Singapore
David E. James
David E. James University of Sydney

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