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Olga Lomovskaya

Olga Lomovskaya

D-Index & Metrics

Microbiology

D-Index
40
Citations
10462
World Ranking
5483
National Ranking
2067

Overview

Olga Lomovskaya is a researcher affiliated with Qpex Biopharma in the United States. Their research contributions primarily focus on the fields of biochemistry, genetics, molecular biology, and medicine, with a notable emphasis on molecular medicine, pharmacology, and molecular biology.

The core areas of their work include antibiotic resistance in bacteria, antibiotics pharmacokinetics and efficacy, bacterial biofilms and quorum sensing, pharmaceutical and antibiotic environmental impacts, tuberculosis research and epidemiology, bacterial identification and susceptibility testing, and pneumonia and respiratory infections.

Lomovskaya has published extensively in several scientific journals. Frequent publication venues include:

  • Antimicrobial Agents and Chemotherapy
  • Open Forum Infectious Diseases
  • Journal of Medicinal Chemistry
  • mBio
  • Nature Communications

Frequent coauthors collaborating with Lomovskaya are Ruslan Tsivkovski, Debora Rubio-Aparicio, Dongxu Sun, Maxim Totrov, and Kirk Nelson.

Key recent papers authored or coauthored by Lomovskaya include:

  • "Discovery of Cyclic Boronic Acid QPX7728, an Ultrabroad-Spectrum Inhibitor of Serine and Metallo-β-lactamases," 2020, Journal of Medicinal Chemistry
  • "A synthetic lipopeptide targeting top-priority multidrug-resistant Gram-negative pathogens," 2022, Nature Communications
  • "Biochemical Characterization of QPX7728, a New Ultrabroad-Spectrum Beta-Lactamase Inhibitor of Serine and Metallo-Beta-Lactamases," 2020, Antimicrobial Agents and Chemotherapy
  • "Spectrum of Beta-Lactamase Inhibition by the Cyclic Boronate QPX7728, an Ultrabroad-Spectrum Beta-Lactamase Inhibitor of Serine and Metallo-Beta-Lactamases: Enhancement of Activity of Multiple Antibiotics against Isogenic Strains Expressing Single Beta-Lactamases," 2020, Antimicrobial Agents and Chemotherapy
  • "QPX7728, An Ultra-Broad-Spectrum B-Lactamase Inhibitor for Intravenous and Oral Therapy: Overview of Biochemical and Microbiological Characteristics," 2021, Frontiers in Microbiology

Best Publications

  • Tackling antibiotic resistance

    Karen Bush;Patrice Courvalin;Gautam Dantas;Julian Davies

  • Identification and Characterization of Inhibitors of Multidrug Resistance Efflux Pumps in Pseudomonas aeruginosa: Novel Agents for Combination Therapy

    Olga Lomovskaya;Mark S. Warren;Angela Lee;Jorge Galazzo

  • Multidrug Pump Inhibitors Uncover Remarkable Activity of Plant Antimicrobials

    George Tegos;Frank R. Stermitz;Olga Lomovskaya;Kim Lewis

  • Emr, an Escherichia coli locus for multidrug resistance.

    O Lomovskaya;K Lewis

  • Practical applications and feasibility of efflux pump inhibitors in the clinic--a vision for applied use.

    Unknown

  • Regulation of Escherichia coli starvation sigma factor (sigma s) by ClpXP protease.

    T Schweder;K H Lee;O Lomovskaya;A Matin

  • Discovery of a Cyclic Boronic Acid β-Lactamase Inhibitor (RPX7009) with Utility vs Class A Serine Carbapenemases.

    Hecker Sj;Reddy Kr;Totrov M;Hirst Gc

  • Effect and Safety of Meropenem–Vaborbactam versus Best-Available Therapy in Patients with Carbapenem-Resistant Enterobacteriaceae Infections: The TANGO II Randomized Clinical Trial

    Richard G. Wunderink;Evangelos J. Giamarellos-Bourboulis;Galia Rahav;Amy J. Mathers

  • EmrR is a negative regulator of the Escherichia coli multidrug resistance pump EmrAB.

    Olga Lomovskaya;Kim Lewis;Anda . Matin

  • Vaborbactam: Spectrum of Beta-Lactamase Inhibition and Impact of Resistance Mechanisms on Activity in Enterobacteriaceae

    Olga Lomovskaya;Dongxu Sun;Debora Rubio-Aparicio;Kirk Nelson

  • Interplay between Efflux Pumps May Provide Either Additive or Multiplicative Effects on Drug Resistance

    Angela Lee;Weimin Mao;Mark S. Warren;Anita Mistry

  • Inhibitors of efflux pumps in Pseudomonas aeruginosa potentiate the activity of the fluoroquinolone antibacterial levofloxacin.

    Thomas E. Renau;Roger Leger;Eric M. Flamme;Joan Sangalang

  • Effect of Meropenem-Vaborbactam vs Piperacillin-Tazobactam on Clinical Cure or Improvement and Microbial Eradication in Complicated Urinary Tract Infection: The TANGO I Randomized Clinical Trial.

    Keith S. Kaye;Tanaya Bhowmick;Symeon Metallidis;Susan C. Bleasdale

  • Use of a Genetic Approach To Evaluate the Consequences of Inhibition of Efflux Pumps in Pseudomonas aeruginosa

    Olga Lomovskaya;Angela Lee;Kazuki Hoshino;Hiroko Ishida

  • MexXY-OprM Efflux Pump Is Necessary for Adaptive Resistance of Pseudomonas aeruginosa to Aminoglycosides

    Didier Hocquet;Christelle Vogne;Farid El Garch;Anne Vejux

  • Inhibition of efflux pumps as a novel approach to combat drug resistance in bacteria.

    Olga Lomovskaya;Will Watkins

  • Waltzing transporters and 'the dance macabre' between humans and bacteria.

    Olga Lomovskaya;Helen I. Zgurskaya;Maxim Totrov;William J. Watkins

  • Discovery of Cyclic Boronic Acid QPX7728, an Ultra-broad-spectrum Inhibitor of Serine and Metallo Beta-lactamases.

    Scott J. Hecker;K. Raja Reddy;Olga Lomovskaya;David C. Griffith

  • Use of an Efflux Pump Inhibitor To Determine the Prevalence of Efflux Pump-Mediated Fluoroquinolone Resistance and Multidrug Resistance in Pseudomonas aeruginosa

    Jane Kriengkauykiat;Edith Porter;Olga Lomovskaya;Annie Wong-Beringer;Annie Wong-Beringer

  • Meropenem-Vaborbactam Resistance Selection, Resistance Prevention, and Molecular Mechanisms in Mutants of KPC-Producing Klebsiella pneumoniae.

    Dongxu Sun;Debora Rubio-Aparicio;Kirk Nelson;Michael N. Dudley

  • A synthetic lipopeptide targeting top-priority multidrug-resistant Gram-negative pathogens

    Unknown

  • On the mechanism of substrate specificity by resistance nodulation division (RND)-type multidrug resistance pumps: the large periplasmic loops of MexD from Pseudomonas aeruginosa are involved in substrate recognition

    Weimin Mao;Mark S. Warren;Deborah S. Black;Takahumi Satou

  • Conformationally-restricted analogues of efflux pump inhibitors that potentiate the activity of levofloxacin in Pseudomonas aeruginosa.

    Thomas E Renau;Roger Léger;Lubov Filonova;Eric M Flamme

  • Efflux pumps: their role in antibacterial drug discovery.

    Unknown

Frequent Co-Authors

Michael N. Dudley
Michael N. Dudley Qpex Biopharma
Mariana Castanheira
Mariana Castanheira JMI Laboratories
Evangelos J. Giamarellos-Bourboulis
Evangelos J. Giamarellos-Bourboulis National and Kapodistrian University of Athens
Abdul Matin
Abdul Matin Stanford University
Rodrigo E. Mendes
Rodrigo E. Mendes JMI Laboratories
Jose A. Vazquez
Jose A. Vazquez Augusta University
Kim Lewis
Kim Lewis Northeastern University
Gautam Dantas
Gautam Dantas Washington University in St. Louis
George M. Weinstock
George M. Weinstock The Jackson Laboratory
Jeffrey H Miller
Jeffrey H Miller University of California, Los Angeles

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