World's Best Scientists 2026 revealed!
Kazuhiro Iwai

Kazuhiro Iwai

D-Index & Metrics

Biology and Biochemistry

D-Index
77
Citations
25861
World Ranking
4712
National Ranking
310

Kazuhiro Iwai publication distribution in Biology and Biochemistry in 2026

The chart shows the distribution of publications by all Research.com ranked scientists in the field of Biology and Biochemistry in 2026. The highlighted bar marks where Kazuhiro Iwai sits on this spectrum.

47–56 publications: 8 scientists 57–66 publications: 35 scientists 67–76 publications: 106 scientists 77–86 publications: 231 scientists 87–96 publications: 414 scientists 97–106 publications: 546 scientists 107–116 publications: 704 scientists 117–126 publications: 849 scientists 127–136 publications: 980 scientists 137–146 publications: 942 scientists 147–156 publications: 969 scientists 157–166 publications: 950 scientists 167–176 publications: 951 scientists 177–186 publications: 915 scientists 187–196 publications: 787 scientists 197–206 publications: 841 scientists 207–216 publications: 735 scientists 217–226 publications: 709 scientists 227–236 publications: 651 scientists 237–246 publications: 605 scientists 247–256 publications: 510 scientists 257–266 publications: 524 scientists 267–276 publications: 434 scientists 277–286 publications: 418 scientists 287–296 publications: 350 scientists 297–306 publications: 363 scientists 307–316 publications: 315 scientists 317–326 publications: 296 scientists 327–336 publications: 261 scientists 337–346 publications: 240 scientists 347–356 publications: 219 scientists 357–366 publications: 197 scientists 367–376 publications: 154 scientists 377–386 publications: 161 scientists 387–396 publications: 155 scientists 397–406 publications: 145 scientists 407–416 publications: 124 scientists 417–426 publications: 112 scientists 427–436 publications: 132 scientists 437–446 publications: 116 scientists 447–456 publications: 99 scientists 457–466 publications: 81 scientists 467–476 publications: 91 scientists 477–486 publications: 80 scientists 487–496 publications: 80 scientists 497–506 publications: 60 scientists 507–516 publications: 36 scientists 517–526 publications: 46 scientists 527–536 publications: 54 scientists 537–546 publications: 44 scientists 547–556 publications: 43 scientists 557–566 publications: 43 scientists 567–576 publications: 42 scientists 577–586 publications: 25 scientists 587–596 publications: 34 scientists 597–606 publications: 23 scientists 607–616 publications: 33 scientists 617–626 publications: 31 scientists 627–636 publications: 27 scientists 637–646 publications: 25 scientists 647–656 publications: 28 scientists 657–666 publications: 34 scientists 667–676 publications: 18 scientists 677–686 publications: 16 scientists 687–696 publications: 10 scientists 697–706 publications: 12 scientists 707–716 publications: 21 scientists 717–726 publications: 12 scientists 727–736 publications: 12 scientists 737–746 publications: 10 scientists 747–756 publications: 7 scientists 757–766 publications: 13 scientists 767–776 publications: 15 scientists 777–786 publications: 13 scientists 787–796 publications: 9 scientists 797–806 publications: 9 scientists 807–816 publications: 7 scientists 817–826 publications: 4 scientists 827–836 publications: 9 scientists 837–846 publications: 7 scientists 847–856 publications: 3 scientists 857–866 publications: 5 scientists 867–876 publications: 5 scientists 877–886 publications: 11 scientists 887–896 publications: 3 scientists 897–906 publications: 4 scientists 907–916 publications: 7 scientists 917–926 publications: 5 scientists 927–936 publications: 6 scientists 937–946 publications: 6 scientists 947–956 publications: 3 scientists 957–966 publications: 7 scientists 967–976 publications: 2 scientists 977–986 publications: 2 scientists 987–996 publications: 1 scientists 997–1,006 publications: 5 scientists 1,007–1,016 publications: 2 scientists 1,017–1,026 publications: 2 scientists 1,027 publications: 1 scientists 1,028+ publications: 100 scientists
47 publications 1,028+

This scientist: 212 publications — 54th percentile

54% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 1,028 publications or more.

Kazuhiro Iwai D-index placement in Biology and Biochemistry in 2026

The chart shows the D-index (discipline H-index) distribution of Biology and Biochemistry scientists ranked by Research.com in 2026. The highlighted bar marks where Kazuhiro Iwai sits on this spectrum.

40–41 D-Index: 80 scientists 42–43 D-Index: 183 scientists 44–45 D-Index: 317 scientists 46–47 D-Index: 504 scientists 48–49 D-Index: 718 scientists 50–51 D-Index: 900 scientists 52–53 D-Index: 1,026 scientists 54–55 D-Index: 1,150 scientists 56–57 D-Index: 1,236 scientists 58–59 D-Index: 1,253 scientists 60–61 D-Index: 1,163 scientists 62–63 D-Index: 1,131 scientists 64–65 D-Index: 1,032 scientists 66–67 D-Index: 897 scientists 68–69 D-Index: 814 scientists 70–71 D-Index: 715 scientists 72–73 D-Index: 709 scientists 74–75 D-Index: 596 scientists 76–77 D-Index: 512 scientists 78–79 D-Index: 473 scientists 80–81 D-Index: 412 scientists 82–83 D-Index: 373 scientists 84–85 D-Index: 358 scientists 86–87 D-Index: 285 scientists 88–89 D-Index: 273 scientists 90–91 D-Index: 227 scientists 92–93 D-Index: 208 scientists 94–95 D-Index: 193 scientists 96–97 D-Index: 153 scientists 98–99 D-Index: 157 scientists 100–101 D-Index: 148 scientists 102–103 D-Index: 120 scientists 104–105 D-Index: 113 scientists 106–107 D-Index: 100 scientists 108–109 D-Index: 86 scientists 110–111 D-Index: 67 scientists 112–113 D-Index: 72 scientists 114–115 D-Index: 73 scientists 116–117 D-Index: 64 scientists 118–119 D-Index: 53 scientists 120–121 D-Index: 60 scientists 122–123 D-Index: 54 scientists 124–125 D-Index: 43 scientists 126–127 D-Index: 38 scientists 128–129 D-Index: 49 scientists 130–131 D-Index: 26 scientists 132–133 D-Index: 18 scientists 134–135 D-Index: 23 scientists 136–137 D-Index: 32 scientists 138–139 D-Index: 32 scientists 140–141 D-Index: 27 scientists 142–143 D-Index: 19 scientists 144–145 D-Index: 22 scientists 146–147 D-Index: 12 scientists 148–149 D-Index: 16 scientists 150–151 D-Index: 14 scientists 152–153 D-Index: 10 scientists 154–155 D-Index: 13 scientists 156–157 D-Index: 10 scientists 158–159 D-Index: 7 scientists 160–161 D-Index: 9 scientists 162–163 D-Index: 13 scientists 164–165 D-Index: 4 scientists 166 D-Index: 4 scientists 167+ D-Index: 98 scientists
40 D-Index 167+

This scientist: 77 D-Index — 76th percentile

76% of scientists in this discipline score the same or lower.

The last bar groups every scientist with 167 D-Index or more.

Overview

Kazuhiro Iwai is affiliated with Kyoto University in Japan and has contributed extensively to the fields of biochemistry, genetics, molecular biology, medicine, immunology, and microbiology. Their research focuses significantly on molecular biology, immunology, oncology, genetics, and cancer research, reflecting a broad engagement with life sciences and medical studies.

The scientist's work covers several main topics, including ubiquitin and proteasome pathways, interferon and immune responses, peptidase inhibition and analysis, genetics and neurodevelopmental disorders, autophagy in disease and therapy, NF-κB signaling pathways, and protein degradation and inhibitors. These areas indicate a specialization in cellular and molecular mechanisms relevant to immune function and disease pathology.

Notable recent papers authored or co-authored by Kazuhiro Iwai include:

  • The HOIL-1L ligase modulates immune signalling and cell death via monoubiquitination of LUBAC, 2020, Nature Cell Biology
  • Iron-induced NCOA4 condensation regulates ferritin fate and iron homeostasis, 2022, EMBO Reports
  • PRDX6 augments selenium utilization to limit iron toxicity and ferroptosis, 2024, Nature Structural & Molecular Biology
  • LUBAC accelerates B-cell lymphomagenesis by conferring resistance to genotoxic stress on B cells, 2020, Blood
  • Loss of peptide: N-glycanase causes proteasome dysfunction mediated by a sugar-recognizing ubiquitin ligase, 2021, Proceedings of the National Academy of Sciences

Frequent collaborators in Kazuhiro Iwai's research include:

  • Katsuhiro Sasaki
  • Yasuhiro Fuseya
  • Erik Walinda
  • Takayuki Tanaka
  • Junko Takita

They have published repeatedly in venues such as:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Blood
  • Journal of Biological Chemistry
  • Proceedings of the Japan Academy Series B
  • The Journal of Biochemistry

Best Publications

  • Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

    Hideki Shimura;Nobutaka Hattori;Shin-ichiro Kubo;Yoshikuni Mizuno

  • Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1.

    Gil Levkowitz;Hadassa Waterman;Seth A Ettenberg;Menachem Katz

  • Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation.

    Fuminori Tokunaga;Shin-ichi Sakata;Shin-ichi Sakata;Yasushi Saeki;Yoshinori Satomi

  • Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex.

    Takumi Kamura;Shigeo Sato;Kazuhiro Iwai;Maria Czyzyk-Krzeska

  • A ubiquitin ligase complex assembles linear polyubiquitin chains

    Takayoshi Kirisako;Kiyoko Kamei;Shigeo Murata;Shigeo Murata;Michiko Kato

  • SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis.

    Fumiyo Ikeda;Yonathan Lissanu Deribe;Sigrid S. Skånland;Benjamin Stieglitz

  • SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex

    Fuminori Tokunaga;Tomoko Nakagawa;Masaki Nakahara;Yasushi Saeki

  • Identification of the von Hippel–Lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex

    Kazuhiro Iwai;Koji Yamanaka;Takumi Kamura;Nagahiro Minato

  • Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice.

    Timothy LaVaute;Sophia Smith;Sharon Cooperman;Kazuhiro Iwai

  • Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis

    Esther G Meyron‐Holtz;Manik C Ghosh;Kazuhiro Iwai;Timothy LaVaute

  • E3 ubiquitin ligase that recognizes sugar chains

    Yukiko Yoshida;Tomoki Chiba;Fuminori Tokunaga;Hiroshi Kawasaki

  • 4F2 (CD98) Heavy Chain Is Associated Covalently with an Amino Acid Transporter and Controls Intracellular Trafficking and Membrane Topology of 4F2 Heterodimer

    Eijiro Nakamura;Masaki Sato;Hailin Yang;Fumi Miyagawa

  • Coordination of PGC-1β and iron uptake in mitochondrial biogenesis and osteoclast activation

    Kiyo-aki Ishii;Toshio Fumoto;Kazuhiro Iwai;Kazuhiro Iwai;Sunao Takeshita

  • NEDD8 recruits E2-ubiquitin to SCF E3 ligase

    Takayuki Kawakami;Tomoki Chiba;Toshiaki Suzuki;Kazuhiro Iwai

  • Structural basis for specific cleavage of Lys 63-linked polyubiquitin chains

    Yusuke Sato;Azusa Yoshikawa;Atsushi Yamagata;Hisatoshi Mimura

  • Heme Induces Ubiquitination and Degradation of the Transcription Factor Bach1

    Yukari Zenke-Kawasaki;Yoshihiro Dohi;Yasutake Katoh;Tsuyoshi Ikura

  • Iron-dependent oxidation, ubiquitination, and degradation of iron regulatory protein 2: Implications for degradation of oxidized proteins

    Kazuhiro Iwai;Steven K. Drake;Nancy B. Wehr;Allan M. Weissman

  • Molecular characterization of a second iron-responsive element binding protein, iron regulatory protein 2. Structure, function, and post-translational regulation.

    F Samaniego;J Chin;K Iwai;T A Rouault

  • Linear polyubiquitination: a new regulator of NF-κB activation

    Kazuhiro Iwai;Fuminori Tokunaga

  • Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin

    Naonobu Fujita;Eiji Morita;Takashi Itoh;Atsushi Tanaka

Frequent Co-Authors

Fuminori Tokunaga
Fuminori Tokunaga Osaka Metropolitan University
Keiji Tanaka
Keiji Tanaka Tokyo Metropolitan Institute of Medical Science
Nagahiro Minato
Nagahiro Minato Kyoto University
Aaron Ciechanover
Aaron Ciechanover Technion – Israel Institute of Technology
Koichiro Ishimori
Koichiro Ishimori Hokkaido University
Yasushi Saeki
Yasushi Saeki Tokyo Metropolitan Institute of Medical Science
Koichi Kato
Koichi Kato National Institutes of Natural Sciences
Tomoki Chiba
Tomoki Chiba University of Tsukuba
Masahiro Shirakawa
Masahiro Shirakawa Kyoto University

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