Kazuhiro Iwai

Overview

Best Publications

• Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

  Hideki Shimura;Nobutaka Hattori;Shin-ichiro Kubo;Yoshikuni Mizuno

  2995
  Citations

• Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1.

  Gil Levkowitz;Hadassa Waterman;Seth A Ettenberg;Menachem Katz

  1261
  Citations

• Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation.

  Fuminori Tokunaga;Shin-ichi Sakata;Shin-ichi Sakata;Yasushi Saeki;Yoshinori Satomi

  1087
  Citations

• Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex.

  Takumi Kamura;Shigeo Sato;Kazuhiro Iwai;Maria Czyzyk-Krzeska

  913
  Citations

• A ubiquitin ligase complex assembles linear polyubiquitin chains

  Takayoshi Kirisako;Kiyoko Kamei;Shigeo Murata;Shigeo Murata;Michiko Kato

  882
  Citations

• SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis.

  Fumiyo Ikeda;Yonathan Lissanu Deribe;Sigrid S. Skånland;Benjamin Stieglitz

  774
  Citations

• SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex

  Fuminori Tokunaga;Tomoko Nakagawa;Masaki Nakahara;Yasushi Saeki

  664
  Citations

• Identification of the von Hippel–Lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex

  Kazuhiro Iwai;Koji Yamanaka;Takumi Kamura;Nagahiro Minato

  628
  Citations

• Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice.

  Timothy LaVaute;Sophia Smith;Sharon Cooperman;Kazuhiro Iwai

  572
  Citations

• Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis

  Esther G Meyron‐Holtz;Manik C Ghosh;Kazuhiro Iwai;Timothy LaVaute

  469
  Citations

• E3 ubiquitin ligase that recognizes sugar chains

  Yukiko Yoshida;Tomoki Chiba;Fuminori Tokunaga;Hiroshi Kawasaki

  442
  Citations

• 4F2 (CD98) Heavy Chain Is Associated Covalently with an Amino Acid Transporter and Controls Intracellular Trafficking and Membrane Topology of 4F2 Heterodimer

  Eijiro Nakamura;Masaki Sato;Hailin Yang;Fumi Miyagawa

  440
  Citations

• Coordination of PGC-1β and iron uptake in mitochondrial biogenesis and osteoclast activation

  Kiyo-aki Ishii;Toshio Fumoto;Kazuhiro Iwai;Kazuhiro Iwai;Sunao Takeshita

  403
  Citations

• NEDD8 recruits E2-ubiquitin to SCF E3 ligase

  Takayuki Kawakami;Tomoki Chiba;Toshiaki Suzuki;Kazuhiro Iwai

  402
  Citations

• Structural basis for specific cleavage of Lys 63-linked polyubiquitin chains

  Yusuke Sato;Azusa Yoshikawa;Atsushi Yamagata;Hisatoshi Mimura

  383
  Citations

• Heme Induces Ubiquitination and Degradation of the Transcription Factor Bach1

  Yukari Zenke-Kawasaki;Yoshihiro Dohi;Yasutake Katoh;Tsuyoshi Ikura

  381
  Citations

• Iron-dependent oxidation, ubiquitination, and degradation of iron regulatory protein 2: Implications for degradation of oxidized proteins

  Kazuhiro Iwai;Steven K. Drake;Nancy B. Wehr;Allan M. Weissman

  379
  Citations

• Molecular characterization of a second iron-responsive element binding protein, iron regulatory protein 2. Structure, function, and post-translational regulation.

  F Samaniego;J Chin;K Iwai;T A Rouault

  310
  Citations

• Linear polyubiquitination: a new regulator of NF-κB activation

  Kazuhiro Iwai;Fuminori Tokunaga

  300
  Citations

• Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin

  Naonobu Fujita;Eiji Morita;Takashi Itoh;Atsushi Tanaka

  296
  Citations