World's Best Scientists 2026 revealed!

D-Index & Metrics

Biology and Biochemistry

D-Index
54
Citations
13284
World Ranking
15469
National Ranking
1096

Overview

Fuminori Tokunaga is affiliated with Osaka Metropolitan University in Japan and has contributed extensively to the fields of Biochemistry, Genetics and Molecular Biology, as well as Medicine. Their research spans several interconnected subfields, including Molecular Biology, Immunology, Cancer Research, Epidemiology, and Neurology.

The scientist's work covers key topics such as ubiquitin and proteasome pathways, NF-κB signaling pathways, and interferon and immune responses. Other research interests include autophagy in disease and therapy, amyotrophic lateral sclerosis research, RNA modifications and cancer, and histone deacetylase inhibitors research.

Frequent co-authors collaborating with Tokunaga include Daisuke Oikawa, Kouhei Shimizu, Yusuke Sato, Seigo Terawaki, and Hirotaka Takahashi.

Tokunaga has published in several scientific venues, with repeated appearances in bioRxiv (Cold Spring Harbor Laboratory), Communications Biology, PLoS ONE, Scientific Reports, and Frontiers in Immunology.

Notable recent publications by Tokunaga feature the following papers:

  • OTUD1 deubiquitinase regulates NF-κB- and KEAP1-mediated inflammatory responses and reactive oxygen species-associated cell death pathways, 2022, Cell Death and Disease
  • Molecular bases for HOIPINs-mediated inhibition of LUBAC and innate immune responses, 2020, Communications Biology
  • Interplay between protein acetylation and ubiquitination controls MCL1 protein stability, 2021, Cell Reports
  • Linear Ubiquitin Code: Its Writer, Erasers, Decoders, Inhibitors, and Implications in Disorders, 2020, International Journal of Molecular Sciences
  • Th2 cells and macrophages cooperatively induce allergic inflammation through histamine signaling, 2021, PLoS ONE

Best Publications

  • Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation.

    Fuminori Tokunaga;Shin-ichi Sakata;Shin-ichi Sakata;Yasushi Saeki;Yoshinori Satomi

  • A ubiquitin ligase complex assembles linear polyubiquitin chains

    Takayoshi Kirisako;Kiyoko Kamei;Shigeo Murata;Shigeo Murata;Michiko Kato

  • SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis.

    Fumiyo Ikeda;Yonathan Lissanu Deribe;Sigrid S. Skånland;Benjamin Stieglitz

  • Tachyplesin, a class of antimicrobial peptide from the hemocytes of the horseshoe crab (Tachypleus tridentatus). Isolation and chemical structure.

    T Nakamura;H Furunaka;T Miyata;F Tokunaga

  • SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex

    Fuminori Tokunaga;Tomoko Nakagawa;Masaki Nakahara;Yasushi Saeki

  • E3 ubiquitin ligase that recognizes sugar chains

    Yukiko Yoshida;Tomoki Chiba;Fuminori Tokunaga;Hiroshi Kawasaki

  • Antimicrobial Peptides, Isolated from Horseshoe Crab Hemocytes, Tachyplesin II, and Polyphemusins I and II: Chemical Structures and Biological Activity

    Toshiyuki Miyata;Fuminori Tokunaga;Takashi Yoneya;Katsuhiro Yoshikawa

  • Heme Induces Ubiquitination and Degradation of the Transcription Factor Bach1

    Yukari Zenke-Kawasaki;Yoshihiro Dohi;Yasutake Katoh;Tsuyoshi Ikura

  • Linear polyubiquitination: a new regulator of NF-κB activation

    Kazuhiro Iwai;Fuminori Tokunaga

  • Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin

    Naonobu Fujita;Eiji Morita;Takashi Itoh;Atsushi Tanaka

  • Gp78 Cooperates with RMA1 in Endoplasmic Reticulum-associated Degradation of CFTRΔF508

    Daisuke Morito;Kazuyoshi Hirao;Yukako Oda;Nobuko Hosokawa

  • Limulus factor C. An endotoxin-sensitive serine protease zymogen with a mosaic structure of complement-like, epidermal growth factor-like, and lectin-like domains.

    T Muta;T Miyata;Y Misumi;F Tokunaga

  • Identification of the ubiquitin-protein ligase that recognizes oxidized IRP2.

    Koji Yamanaka;Haruto Ishikawa;Haruto Ishikawa;Yuzuru Megumi;Fuminori Tokunaga

  • Linear Ubiquitin Assembly Complex Negatively Regulates RIG-I- and TRIM25-Mediated Type I Interferon Induction

    Kyung-Soo Inn;Michaela U. Gack;Michaela U. Gack;Fuminori Tokunaga;Mude Shi

  • Fbs2 is a new member of the E3 ubiquitin ligase family that recognizes sugar chains

    Yukiko Yoshida;Fuminori Tokunaga;Tomoki Chiba;Kazuhiro Iwai

  • Specific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF‐κB regulation

    Fuminori Tokunaga;Fuminori Tokunaga;Hiroshi Nishimasu;Ryuichiro Ishitani;Eiji Goto

  • Molecular characterization of the "26S" proteasome complex from rat liver

    T. Yoshimura;K. Kameyama;T. Takagi;A. Ikai

  • Involvement of Heme Regulatory Motif in Heme-Mediated Ubiquitination and Degradation of IRP2

    Haruto Ishikawa;Michiko Kato;Hiroshi Hori;Koichiro Ishimori

  • The factor V-activating enzyme (RVV-V) from Russell's viper venom. Identification of isoproteins RVV-V alpha, -V beta, and -V gamma and their complete amino acid sequences.

    F Tokunaga;K Nagasawa;S Tamura;T Miyata

  • Primary structure of anti-lipopolysaccharide factor from American horseshoe crab, Limulus polyphemus.

    Tatsushi Muta;Toshiyuki Miyata;Fuminori Tokunaga;Takanori Nakamura

Frequent Co-Authors

Kazuhiro Iwai
Kazuhiro Iwai Kyoto University
Keiji Tanaka
Keiji Tanaka Tokyo Metropolitan Institute of Medical Science
Tatsuya Sawasaki
Tatsuya Sawasaki Ehime University
Osamu Ishikawa
Osamu Ishikawa Gunma University
Sadaaki Iwanaga
Sadaaki Iwanaga Kyushu University
Osamu Nureki
Osamu Nureki University of Tokyo
Yasushi Saeki
Yasushi Saeki Tokyo Metropolitan Institute of Medical Science
Ryuichiro Ishitani
Ryuichiro Ishitani University of Tokyo
Koichi Kato
Koichi Kato National Institutes of Natural Sciences
Akemi Ishida-Yamamoto
Akemi Ishida-Yamamoto Asahikawa Medical University

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