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Ryuichiro Ishitani

Ryuichiro Ishitani

D-Index & Metrics

Biology and Biochemistry

D-Index
74
Citations
21685
World Ranking
5547
National Ranking
357

Overview

Ryuichiro Ishitani is affiliated with the University of Tokyo in Japan. Their research spans across multiple disciplines within biochemistry, genetics, and molecular biology, with a primary focus on molecular biology. Other subfields of study include materials chemistry, computational theory and mathematics, cellular and molecular neuroscience, and physiology.

The scientist's work covers several main topics, reflecting a multidisciplinary approach. These topics include computational drug discovery methods, machine learning applications in materials science, protein structure and dynamics, RNA and protein synthesis mechanisms, sphingolipid metabolism and signaling, microbial metabolic engineering and bioproduction, and bioinformatics and genomic networks.

Among recent publications by Ryuichiro Ishitani are:

  • Towards universal neural network potential for material discovery applicable to arbitrary combination of 45 elements, 2022, Nature Communications
  • Crystal structure of Drosophila Piwi, 2020, Nature Communications
  • Time-resolved serial femtosecond crystallography reveals early structural changes in channelrhodopsin, 2021, eLife
  • Cryo-EM structure of the volume-regulated anion channel LRRC8D isoform identifies features important for substrate permeation, 2020, Communications Biology
  • Identification of Potent In Vivo Autotaxin Inhibitors that Bind to Both Hydrophobic Pockets and Channels in the Catalytic Domain, 2020, Journal of Medicinal Chemistry

They frequently co-author with several researchers, including Osamu Nureki, Mizuki Takemoto, Keitaro Yamashita, Hiroshi Nishimasu, and Go Kasuya.

Ryuichiro Ishitani has contributed to multiple publication venues, notably:

  • bioRxiv (Cold Spring Harbor Laboratory)
  • Zenodo (CERN European Organization for Nuclear Research)
  • Nature Communications
  • PLoS ONE
  • eLife

Best Publications

  • Crystal structure of Cas9 in complex with guide RNA and target DNA

    Takashi Yamano;Hiroshi Nishimasu;Hiroshi Nishimasu;Bernd Zetsche;Hisato Hirano

  • Crystal Structure of the Complex of Human Epidermal Growth Factor and Receptor Extracellular Domains.

    Hideo Ogiso;Ryuichiro Ishitani;Osamu Nureki;Shuya Fukai

  • Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA

    Hiroshi Nishimasu;Naoshi Dohmae;Ryuichiro Ishitani;Osamu Nureki

  • Engineered CRISPR-Cas9 nuclease with expanded targeting space

    Hiroshi Nishimasu;Xi Shi;Xi Shi;Soh Ishiguro;Soh Ishiguro;Linyi Gao;Linyi Gao

  • Crystal structure of the channelrhodopsin light-gated cation channel

    Hideaki E. Kato;Feng Zhang;Ofer Yizhar;Charu Ramakrishnan

  • Crystal Structure of Staphylococcus aureus Cas9

    Hiroshi Nishimasu;Hiroshi Nishimasu;Le Cong;Winston X. Yan;F. Ann Ran;F. Ann Ran

  • Structure and Engineering of Francisella novicida Cas9.

    Hisato Hirano;Jonathan S. Gootenberg;Takuro Horii;Omar O. Abudayyeh

  • Structure and function of Zucchini endoribonuclease in piRNA biogenesis

    Hiroshi Nishimasu;Hirotsugu Ishizu;Hirotsugu Ishizu;Kuniaki Saito;Satoshi Fukuhara

  • Crystal structure of a claudin provides insight into the architecture of tight junctions.

    Hiroshi Suzuki;Tomohiro Nishizawa;Kazutoshi Tani;Yuji Yamazaki

  • Structural basis for orthogonal tRNA specificities of tyrosyl-tRNA synthetases for genetic code expansion

    T. Kobayashi;O. Nureki;R. Ishitani;Anna Yaremchuk

  • Cap-specific terminalN6-methylation of RNA by an RNA polymerase II-associated methyltransferase.

    S. Akichika;S. Hirano;Y. Shichino;T. Suzuki

  • Structure and function of a membrane component SecDF that enhances protein export

    Tomoya Tsukazaki;Hiroyuki Mori;Yuka Echizen;Ryuichiro Ishitani

  • Crystal structure of autotaxin and insight into GPCR activation by lipid mediators

    Hiroshi Nishimasu;Shinichi Okudaira;Kotaro Hama;Emiko Mihara

  • Structural basis of Sec-independent membrane protein insertion by YidC

    Kaoru Kumazaki;Shinobu Chiba;Mizuki Takemoto;Arata Furukawa

  • Conformational transition of Sec machinery inferred from bacterial SecYE structures

    Tomoya Tsukazaki;Hiroyuki Mori;Shuya Fukai;Shuya Fukai;Ryuichiro Ishitani

  • Structural basis for the drug extrusion mechanism by a MATE multidrug transporter

    Yoshiki Tanaka;Christopher J. Hipolito;Andrés D. Maturana;Koichi Ito

  • Crystal Structure of the Homologous-Pairing Domain from the Human Rad52 Recombinase in the Undecameric Form

    Wataru Kagawa;Hitoshi Kurumizaka;Ryuichiro Ishitani;Shuya Fukai

  • Cyclic GMP-AMP as an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA.

    Kazuki Kato;Hiroki Omura;Ryuichiro Ishitani;Osamu Nureki

  • Structural basis for Na + transport mechanism by a light-driven Na + pump

    Hideaki E. Kato;Keiichi Inoue;Rei Abe-Yoshizumi;Yoshitaka Kato

  • Alternative Tertiary Structure of tRNA for Recognition by a Posttranscriptional Modification Enzyme

    Ryuichiro Ishitani;Osamu Nureki;Nobukazu Nameki;Norihiro Okada

Frequent Co-Authors

Osamu Nureki
Osamu Nureki University of Tokyo
Hiroshi Nishimasu
Hiroshi Nishimasu University of Tokyo
Junken Aoki
Junken Aoki Tohoku University
Dieter Söll
Dieter Söll Yale University
Yuji Sugita
Yuji Sugita RIKEN Center for Biosystems Dynamics Research
Fuminori Tokunaga
Fuminori Tokunaga Osaka Metropolitan University
Tsutomu Suzuki
Tsutomu Suzuki University of Tokyo

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