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Hiroshi Nishimasu

Hiroshi Nishimasu

D-Index & Metrics

Biology and Biochemistry

D-Index
51
Citations
16639
World Ranking
16940
National Ranking
1221

Overview

Hiroshi Nishimasu is affiliated with the University of Tokyo in Japan and has a research focus primarily within Biochemistry, Genetics, and Molecular Biology. Their academic work spans several specialized subfields including Molecular Biology, Genetics, Plant Science, Immunology, and Cardiology and Cardiovascular Medicine.

The scientist's publications address a wide range of topics, with a strong emphasis on CRISPR and Genetic Engineering, RNA and protein synthesis mechanisms, and advanced biosensing and bioanalysis techniques. Additional research interests include RNA regulation and disease, chromosomal and genetic variations, viral infections and immunology research, as well as mosquito-borne diseases and control.

  • CRISPR and Genetic Engineering
  • RNA and protein synthesis mechanisms
  • Advanced biosensing and bioanalysis techniques
  • RNA regulation and disease
  • Chromosomal and Genetic Variations
  • Viral Infections and Immunology Research
  • Mosquito-borne diseases and control

Recent publications by Nishimasu showcase contributions to high-impact journals, highlighting ongoing developments in gene editing and molecular biology techniques. Selected papers include:

  • "Amplification-free RNA detection with CRISPR-Cas13" (2021, Communications Biology)
  • "Base editors for simultaneous introduction of C-to-T and A-to-G mutations" (2020, Nature Biotechnology)
  • "Structure of the miniature type V-F CRISPR-Cas effector enzyme" (2020, Molecular Cell)
  • "Bridge RNAs direct programmable recombination of target and donor DNA" (2024, Nature)
  • "Rapid in silico directed evolution by a protein language model with EVOLVEpro" (2024, Science)

Frequent publication venues reflect the scientist's engagement with prominent journals in biology and biotechnology fields, including Communications Biology, bioRxiv (Cold Spring Harbor Laboratory), Nature, Science, and Nature Communications.

  • Communications Biology
  • bioRxiv (Cold Spring Harbor Laboratory)
  • Nature
  • Science
  • Nature Communications

Nishimasu has collaborated extensively with several co-authors over multiple publications. Notable frequent collaborators are:

  • Osamu Nureki
  • Sae Okazaki
  • Keitaro Yamashita
  • Tomohiro Nishizawa
  • Ryoya Nakagawa

Best Publications

  • Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex

    Silvana Konermann;Mark D. Brigham;Alexandro E. Trevino;Julia Joung

  • Crystal structure of Cas9 in complex with guide RNA and target DNA

    Takashi Yamano;Hiroshi Nishimasu;Hiroshi Nishimasu;Bernd Zetsche;Hisato Hirano

  • Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA

    Hiroshi Nishimasu;Naoshi Dohmae;Ryuichiro Ishitani;Osamu Nureki

  • Engineered CRISPR-Cas9 nuclease with expanded targeting space

    Hiroshi Nishimasu;Xi Shi;Xi Shi;Soh Ishiguro;Soh Ishiguro;Linyi Gao;Linyi Gao

  • Crystal Structure of Staphylococcus aureus Cas9

    Hiroshi Nishimasu;Hiroshi Nishimasu;Le Cong;Winston X. Yan;F. Ann Ran;F. Ann Ran

  • Engineered Cpf1 variants with altered PAM specificities

    Linyi Gao;Linyi Gao;David B T Cox;David B T Cox;Winston X Yan;Winston X Yan;Winston X Yan;John C Manteiga

  • Structure and Engineering of Francisella novicida Cas9.

    Hisato Hirano;Jonathan S. Gootenberg;Takuro Horii;Omar O. Abudayyeh

  • Structure and function of Zucchini endoribonuclease in piRNA biogenesis

    Hiroshi Nishimasu;Hirotsugu Ishizu;Hirotsugu Ishizu;Kuniaki Saito;Satoshi Fukuhara

  • Cap-specific terminalN6-methylation of RNA by an RNA polymerase II-associated methyltransferase.

    S. Akichika;S. Hirano;Y. Shichino;T. Suzuki

  • Crystal structure of autotaxin and insight into GPCR activation by lipid mediators

    Hiroshi Nishimasu;Shinichi Okudaira;Kotaro Hama;Emiko Mihara

  • Structural Basis for the Canonical and Non-canonical PAM Recognition by CRISPR-Cpf1.

    Takashi Yamano;Bernd Zetsche;Ryuichiro Ishitani;Feng Zhang

  • Specific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF‐κB regulation

    Fuminori Tokunaga;Fuminori Tokunaga;Hiroshi Nishimasu;Ryuichiro Ishitani;Eiji Goto

  • Real-space and real-time dynamics of CRISPR-Cas9 visualized by high-speed atomic force microscopy.

    Mikihiro Shibata;Hiroshi Nishimasu;Hiroshi Nishimasu;Noriyuki Kodera;Noriyuki Kodera;Seiichi Hirano

  • Genome editing in plants by engineered CRISPR-Cas9 recognizing NG PAM.

    Masaki Endo;Masafumi Mikami;Masafumi Mikami;Akira Endo;Akira Endo;Hidetaka Kaya;Hidetaka Kaya

  • Amplification-free RNA detection with CRISPR-Cas13.

    Hajime Shinoda;Yuya Taguchi;Ryoya Nakagawa;Asami Makino

  • Crystal Structure of the Minimal Cas9 from Campylobacter jejuni Reveals the Molecular Diversity in the CRISPR-Cas9 Systems

    Mari Yamada;Yuto Watanabe;Jonathan S. Gootenberg;Hisato Hirano

  • Base editors for simultaneous introduction of C-to-T and A-to-G mutations

    Rina C. Sakata;Rina C. Sakata;Soh Ishiguro;Soh Ishiguro;Hideto Mori;Hideto Mori;Mamoru Tanaka

  • Structural Basis for the Altered PAM Specificities of Engineered CRISPR-Cas9

    Seiichi Hirano;Hiroshi Nishimasu;Hiroshi Nishimasu;Ryuichiro Ishitani;Osamu Nureki

  • Crystal Structure of Silkworm PIWI-Clade Argonaute Siwi Bound to piRNA

    Naoki Matsumoto;Hiroshi Nishimasu;Hiroshi Nishimasu;Kazuhiro Sakakibara;Kazumichi M. Nishida

  • Crystal structure of Enpp1, an extracellular glycoprotein involved in bone mineralization and insulin signaling

    Kazuki Kato;Hiroshi Nishimasu;Shinichi Okudaira;Emiko Mihara

Frequent Co-Authors

Osamu Nureki
Osamu Nureki University of Tokyo
Ryuichiro Ishitani
Ryuichiro Ishitani University of Tokyo
Junken Aoki
Junken Aoki Tohoku University
Shinya Fushinobu
Shinya Fushinobu University of Tokyo
Hirotatsu Kojima
Hirotatsu Kojima University of Tokyo
Mikiko C. Siomi
Mikiko C. Siomi University of Tokyo
Junichi Takagi
Junichi Takagi Osaka University
Haruhiko Siomi
Haruhiko Siomi Keio University

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