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Neville E. Sanjana

Neville E. Sanjana

New York University
United States

Overview

What is he best known for?

The fields of study he is best known for:

Gene
DNA
Genome

Genetics, CRISPR, Cas9, Computational biology and Guide RNA are his primary areas of study. In general Genetics study, his work on Genomics, Genome editing, Genetic screen and Methylation often relates to the realm of N6-Methyladenosine, thereby connecting several areas of interest. His CRISPR research is included under the broader classification of Gene.

Neville E. Sanjana combines subjects such as RNA interference, High-throughput screening and Functional genomics with his study of Cas9. His Computational biology study combines topics in areas such as RNA and Epitranscriptomics. His research in Guide RNA intersects with topics in Chromatin, Gene Knockout Techniques and Enhancer, Enhancer trap.

His most cited work include:

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells (3083 citations)
Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells (3083 citations)
Improved vectors and genome-wide libraries for CRISPR screening. (2310 citations)

What are the main themes of his work throughout his whole career to date?

Neville E. Sanjana focuses on CRISPR, Computational biology, Genetics, Gene and Cas9. His CRISPR research incorporates elements of Genetic screen, Genome and Functional genomics. His study looks at the relationship between Computational biology and topics such as RNA, which overlap with Gene knockdown.

His study on Leigh disease, Mitochondrion and Vector is often connected to NDUFS4 and Complex formation as part of broader study in Genetics. His Gene research focuses on Cancer research and how it relates to Immunology. His work on CRISPR interference as part of general Cas9 research is frequently linked to Genomic library, thereby connecting diverse disciplines of science.

He most often published in these fields:

CRISPR (69.29%)
Computational biology (50.39%)
Genetics (53.54%)

What were the highlights of his more recent work (between 2019-2021)?

Gene (48.03%)
CRISPR (69.29%)
Computational biology (50.39%)

In recent papers he was focusing on the following fields of study:

His primary areas of study are Gene, CRISPR, Computational biology, Phenotype and Gene expression. Neville E. Sanjana is interested in Cas9, which is a branch of CRISPR. Neville E. Sanjana interconnects Genome editing, Genome and Gene knockout in the investigation of issues within Computational biology.

His Genome study is focused on Genetics in general. The various areas that Neville E. Sanjana examines in his Phenotype study include DUX4, Progenitor cell, Transcriptional regulation, Induced pluripotent stem cell and Neuroscience. As a member of one scientific family, Neville E. Sanjana mostly works in the field of Gene knockdown, focusing on Guide RNA and, on occasion, RNA virus and Transcriptome.

Between 2019 and 2021, his most popular works were:

Identification of Required Host Factors for SARS-CoV-2 Infection in Human Cells. (89 citations)
The D614G mutation in SARS-CoV-2 Spike increases transduction of multiple human cell types (88 citations)
The Spike D614G mutation increases SARS-CoV-2 infection of multiple human cell types (73 citations)

In his most recent research, the most cited papers focused on:

Gene
DNA
Genome

Neville E. Sanjana mainly focuses on CRISPR, Gene, Point mutation, Virus and Transduction. Cas9 is the focus of his CRISPR research. Neville E. Sanjana has included themes like Gene knockout and Dna targeting in his Cas9 study.

His Point mutation study is associated with Genetics. His Computational biology study incorporates themes from Genome editing, Epigenetics and Zebrafish. His work deals with themes such as RNA, RNA interference, Loss function and Guide RNA, which intersect with Gene knockdown.

This overview was generated by a machine learning system which analysed the scientist’s body of work. If you have any feedback, you can contact us here.

Best Publications

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

Ophir Shalem;Ophir Shalem;Neville E Sanjana;Neville E Sanjana;Ella Hartenian;Xi-Shun Shi.
Science (2014)

11951 Citations

Improved vectors and genome-wide libraries for CRISPR screening.

Neville E Sanjana;Ophir Shalem;Feng Zhang.
Nature Methods (2014)

3500 Citations

High-throughput functional genomics using CRISPR–Cas9

Ophir Shalem;Ophir Shalem;Neville E. Sanjana;Neville E. Sanjana;Feng Zhang;Feng Zhang.
Nature Reviews Genetics (2015)

987 Citations

A transcription activator-like effector toolbox for genome engineering

Neville E Sanjana;Le Cong;Le Cong;Le Cong;Yang Zhou;Yang Zhou;Margaret M Cunniff;Margaret M Cunniff.
Nature Protocols (2012)

862 Citations

Perturbation of m6A Writers Reveals Two Distinct Classes of mRNA Methylation at Internal and 5′ Sites

Schraga Schwartz;Maxwell R. Mumbach;Marko Jovanovic;Tim Wang;Tim Wang.
Cell Reports (2014)

862 Citations

BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis

Matthew C. Canver;Elenoe C. Smith;Falak Sher;Luca Pinello.
Nature (2015)

712 Citations

Genome-wide CRISPR screen in a mouse model of tumor growth and metastasis

Sidi Chen;Sidi Chen;Neville E. Sanjana;Kaijie Zheng;Ophir Shalem.
Cell (2015)

669 Citations

Identification of essential genes for cancer immunotherapy

Shashank J. Patel;Neville E. Sanjana;Rigel J. Kishton;Arash Eidizadeh.
Nature (2017)

608 Citations

Genome-scale CRISPR-Cas9 knockout and transcriptional activation screening

Julia Joung;Silvana Konermann;Jonathan S Gootenberg;Omar O Abudayyeh.
Nature Protocols (2017)

493 Citations

A Genome-wide CRISPR Screen in Primary Immune Cells to Dissect Regulatory Networks

Oren Parnas;Marko Jovanovic;Thomas M. Eisenhaure;Thomas M. Eisenhaure;Rebecca H. Herbst;Rebecca H. Herbst.
Cell (2015)

410 Citations

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Frequent Co-Authors

External Links

Personal Website for Neville E. Sanjana